SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Kwan-Hyuck Baek
Kwan-Hyuck Baek PhD
| Graduate Program | Cancer Biology |
| Research Area | Cancer Microenvironment |
| Laboratory | Lab of tumor microenvironment Laboratory |
| khbaek@skku.edu | |
| Tel | +82-31-299-6162 |
Education & Careers
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1990-2002 B.S., M.S., and Ph.D in Cellular Immunology, Pohang Univ. of Science and Technology
2003-2005 Postdoctoral Fellow, National Cancer Center
2006-2009 Research Fellow, Harvard Medical School
2009-2010 Postdoctoral Fellow, University of Pennsylvania School of Medicine
2010-present SKKU SOM Assistant/Associate professor
Research Interest
[1] Angiogenesis is implicated in the development of various diseases including cancer. Currently, we are working on the role of various signaling pathways, especially focusing on S6K-mediated pathway, in determining angiogenic behavior within tumor microenvironment for fully understanding angiogenic process during tumor development.
[2] 3-dimensional organoid culture system is emerging as a potent in vitro model for studying various disorders and diseases including cancer. Currently, we are working on development of 3D organoid culture models and their application for studying molecular mechanisms underlying tumor development as well as personalized cancer treatment.
[2] 3-dimensional organoid culture system is emerging as a potent in vitro model for studying various disorders and diseases including cancer. Currently, we are working on development of 3D organoid culture models and their application for studying molecular mechanisms underlying tumor development as well as personalized cancer treatment.
Representative Research Achievements
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1. Lee S, Roh HS, Song SS, Shin J, Lee JC, Bhang DH, Kim BG, Um SH, Jeong HS, Baek KH (2020). Loss of S6K1 but not S6K2 in the tumor microenvironment suppresses tumor growth by attenuating tumor angiogenesis. Transl. Oncol. 13 (4):100767. doi: 10.1016/j.tranon.2020.100767.
2. Bhang DH, Kim BJ, Kim BG, Schadler K, Baek KH, Kim YH, Hsiao W, Ding BS, Rafii S, Weiss MJ, Chou ST, Kolon TF, Ginsberg JP, Ryu BY, Ryeom S (2018). Testicular endothelial cells are a critical population in the germline stem cell niche. Nat. Commun. 9. 4379. doi: 10.1038/s41467-018-06881-z.
3. Shin J, Lee JC and Baek KH. A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. Cancer Lett. 2014. 342(1):70-81.
4. Baek KH, Bhang D, Zaslavsky A, Wang LC, Vachani A, Kim CF, Albelda SM, Evan GI and Ryeom S. Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors. J. Clin. Invest. 2013. 123(10): 4375-4389.
5. Baek KH, Zaslavsky A, Lynch R, Britt C, Okada Y, Siarey R, Lensch W, Park IH, Yoon S, Minami T, Reeves R, Korenberg J, Folkman J, Daley G, Aird W, Galdzicki Z, and Ryeom S (2009). Down’s syndrome suppression of tumor growth and the role of the calcineurin inhibitor DSCR1. Nature. 459. 1126-1130.