SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Joo-Ho Shin
Joo-Ho Shin PhD
| Graduate Program | Neuroscience |
| Research Area | Parkinson Disease & Neuroprotection |
| Laboratory | Lab of NeuroRegeneration Laboratory |
| jshin24@skku.edu | |
| Tel | +82-31-299-6192 |
Education & Careers
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1998 B.S., Seoul National University (Animal Sci. & Tech)
2003 M.S., Seoul National University (Medicine, Cancer Research)
2005 Ph.D., University of Vienna (Chemistry, Proteomics)
2005-2006, Postdoctoral Researcher, Medical University of Vienna
2006-2012, Postdoctoral fellow, Johns Hopkins University
2018-2019, Visiting Assistant professor, Johns Hopkins University
2016-present, Assistant/Associate professor, Department of Pharmacology, SKKU-SOM
Research Interest
&9642 ive mechanism of dopaminergic neuronal death
&9642 Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
&9642 Relationship between neurodegeneration and liquid-liquid phase separation
&9642 Functional studies of protein lipidation
&9642 Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
&9642 Relationship between neurodegeneration and liquid-liquid phase separation
&9642 Functional studies of protein lipidation
Representative Research Achievements
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1. Areum Jo, Yunjong Lee, Chi-Hu Park, Joo-Ho Shin* (2019) Deubiquitinase USP29 governs MYBBP1A in the brains of Parkinson’s disease patients. Journal of Clinical Medicine, 9(52).
2. Hojin Kang, Areum Jo, Hyein Kim, Rin Khang, Ji-Yeong Lee, Hanna Kim, Chi-Hu Park, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shin* (2018) PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration. Biochemical and Biophysical Research Communications, 495(4), 2498-2504.
3. Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee* and Joo-Ho Shin* (2017) Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget, 8(30), 48603-48618.
4. Y Lee, DA. Stevens, S-U Kang, H Jiang, Y-I Lee, HS Ko, LA. Scarffe, GE. Umanah, H Kang, S Ham, T-I Kam, K Allen, S Brahmachari, JW Kim, S Neifert, SP Yun, FC. Fiesel, W Springer, VL. Dawson*, J-H Shin*, TM. Dawson* (2017) PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Report, 18(4), 918-932.
5. Yun-Il Lee, Hojin Kang, Young Wan Ha, Ki-Young Chang, Sung-Chun Cho, Sang Ok Song, Hyein Kim, Areum Jo, Rin Khang, Jeong-Yun Choi, Yunjong Lee, Sang Chul Park, Joo-Ho Shin* (2016) Diaminodiphenyl sulfone&8211induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiology of Aging, 41, 1-10.
6. Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin* and Ted M. Dawson* (2015) Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America, 112(37), 11696-11701 *Corresponding author