We are witnessing the beginning of a new generation of medicine. The unprecedented amount of large-scale next generation sequencing data from patients with cancer and other diseases makes data science and artificial intelligence (AI) play a pivotal role in biomedical research. The pressing question is how to best translate the accumulated data into a more effective practice of medicine. Next-Gen Medicine Lab aims to analyze the biological big-data with AI and data science approaches to find a better way to treat cancer. Our research covers highly translationally important questions in multiple fields of cancer biology and medicine with primary focus on precision cancer medicine, tailoring the cancer treatments based on the molecular markup of individual patients from the perspective of AI and data science.