SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Sungkwon Chung
Sungkwon Chung PhD
| Graduate Program | Neuroscience |
| Research Area | Cholesterol Regulation of Amyloid Production |
| Laboratory | Neuropathophysiology Laboratory |
| schung@skku.edu | |
| Tel | +82-31-299-6103 |
Education & Careers
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- Seoul National University, Chemistry, B.S. (1983)
- Seoul National University, Biochemistry, M.S. (1985)
- Brandeis University, Biochemistry, Ph. D. (1991)
- Yale Medical School, Pharmacology, Post Doc. (1991-1994)
- Asan Research Center (Seoul), Senior Researcher (1994-1996)
- Chung-Ang University School of Medicine, Assistant Professor (1996-1999)
- Sungkyunkwan University School of Medicine, Professor (1999- current)
Research Interest
Alzheimer’s Disease (AD) is a typical neurodegenerative disease caused by increased amyloid b-protein (Ab) production. One of main genetic cause of AD is mutations in presenilin protein, which increases the production of Ab. We previously reported for the first time that presenilin mutation induces calcium signaling dysfunction (Yoo et al., Neuron, 2000). We also reported that presenilin mutation decreases one of major lipid component in plasma membrane (PIP2), which resulted in the decreased TRPM7 channel activity (Landman et al., PNAS, 2006). Currently, we study the molecular mechanism for the regulation of Ab production in relation to calcium signaling. Based on our research results, we also try to find a new target for therapeutic drugs for AD.
Representative Research Achievements
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1. Cho YY, Kwon OH, Park MK, Kim T-W*, Chung S* (2019) Elevated cellular cholesterol in Familial Alzheimer’s presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein. PLOS One 14:e0210535. *co-corresponding authors
2. Kwon OH, Cho YY, Kim TW, Chung SO-GlcNAcylation of amyloid-b protein precursor by insulin signaling reduces amyloid&8211b production. (2019). J. Alzheimer’s Disease 69:1195.
3. Chun YS, Zhang L, Li H, Park Y, Chung S*, Yang HO* (2018) 7-Deoxy-trans-dihydronarciclasine Reduces β-Amyloid and Ameliorates Memory Impairment in a Transgenic Model of Alzheimer’s Disease. Mol. Neurobiol. 55:8953. *co-corresponding authors
4. Chun YS, Kwon OH, Oh HG, Cho YY Chung S*, Yang HO* (2018) Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein. Biomol. Therapeu. 27:276. *co-corresponding authors
5. Chun YS, Park Y, Oh HG, Kim T-W, Yang H, Park M, Chung S (2015) O-GlcNAcylation promotes non-amyloidogenic processing of amyloid-b protein precursor via inhibition of endocytosis from the plasma membrane. J. Alzheimer’s Disease 44:261.