SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Chang-Woo Lee
Chang-Woo Lee PhD
| Graduate Program | Cancer Biology |
| Research Area | Molecular Oncology, Tumor Immunology, autoimmunity |
| Laboratory | Molecular Tumor Immunology Laboratory Laboratory |
| cwlee1234@skku.edu | |
| Tel | +82-31-299-6121 |
Education & Careers
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1982-1986 B.S. in Life Science, Pusan National University, Korea
1991-1994 Research Assistant, Dept. of Life Science, POSTECH, Korea
1994-1998 Ph.D. in Cell Biology, University of Glasgow/National Institute for Medical Research, UK (Supervisor, Prof. Nick La Thangue)
1998-2000 Postdoctoral Research Fellow, Dept. of Cell Biology, Harvard Medical School, USA (Supervisor, Prof. Frank McKeon)
2000-2002 Research Professor, Div. of Molecular and Life Science, POSTECH, Korea
2002-2005 Senior Research Associate, Liver and Pancreatobiliary Cancer Branch, Research Institute, National Cancer Center, Korea
2006-2011 Associate Professor, Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea
2012-present Professor, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Korea
2010-present Professor, Division of Molecular Medicine, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Korea
Research Interest
1. Tumor biology and Anti-tumor immunity
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity and autoimmune disease therapy
: Receptor-mediated signaling mechanism in regulating autoimmunity and the development of autoimmune disease therapeutic strategy
3. Hepatic metabolic disorders and hepatocellular carcinoma
: Study of novel molecular mechanism of steatohepatitis and hepatocellular carcinoma, and development of its relevant therapeutic strategy
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity and autoimmune disease therapy
: Receptor-mediated signaling mechanism in regulating autoimmunity and the development of autoimmune disease therapeutic strategy
3. Hepatic metabolic disorders and hepatocellular carcinoma
: Study of novel molecular mechanism of steatohepatitis and hepatocellular carcinoma, and development of its relevant therapeutic strategy
Representative Research Achievements
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1. Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks. Nature Communications 2019 10:1577: 1-18. (IF 12.353)
2. De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair. Nucleic Acids Research 2019 9:47 6299-6314. (IF 12.353)
3. The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nature Communications 2018, (IF 12.353)
4. Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology 2015, 63(2016): 247-259 (IF 14.079)
5. Pellino1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. Journal of Clinical Investigation 2014, 124(11): 4976-4988 (IF 13.251)