SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Jong-Sun Kang
Jong-Sun Kang PhD
| Graduate Program | Development & Regenerative Medicine |
| Research Area | Stem cell function control mechanism, muscle/cardiovascular disease mechanism and treatment development |
| Laboratory | Stem cell differentiation laboratory Laboratory |
| kangj01@skku.edu | |
| Tel | +82-31-299-6135 |
Education & Careers
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1981-1985 Pusan National University, Biology, BS
1985-1994 Albert-Ludwigs University Freiburg, Germany, Molecular Biology, Diproma and
PhD
1994-2007 Mount Sinai School of Medicine, New York, USA Biochemistry & Molecular
Biology, Postdoc, Instructor, Assistant Professor
2007~present Sungkyunkwan University School of Medicine, Associate Professor, Professor
Research Interest
The goal of the research in my laboratory is to understand the molecular regulatory pathways that control proliferation and differentiation of stem cells during regeneration and underlying molecular mechanisms in stem cell dysfunction related to aging or degenerative diseases. Our current research is focused on the elucidation of regulatory mechanisms and in vivo function of key stem niche signals (Sonic hedgehog and Wnt), cell adhesion molecules and protein arginine methyltransferases by utilizing knockout mice, disease animal models and stem cells as model systems. The long-term goal of this research is to identify molecular targets for the development of therapeutic tools to intervene the aging-related muscle atrophy, cardiovascular diseases or degenerative diseases.
Representative Research Achievements
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Lee et al., 2019. Protein arginine methyltransferase 7 regulates the leak channel NALCN activity in hippocampal dentate granule cells. Exp. Mol. Med., in press.
Jeong et al., 2019. Prmt7 promotes myoblast differentiation via methylation of p38MAPK on arginine residue 70. Cell death & differentiation, in press.
Voung et al., 2019. PRMT7 methylates and suppresses GLI2 binding to SUFU thereby promoting its activation. Cell death & differentiation, in press.
Choi et al., 2019. Skeletal muscle-specific PRMT1 deletion causes muscle atrophy via deregulation of PRMT6/FOXO3 axis. Autophagy. In press.
Voung et al., 2019. SGTb regulates the surface localization of a guidance receptor BOC to promote neurite outgrowth. Cellular Signaling, 55, 100-108.
Pyun et al., 2018. Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation. Nature Communications, 9(1), 5107
Jeong et al., 2017. Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/b-catenin signaling. PNAS, 114(8), E1345-1354.
Tuan et al., 2016. A sonic hedgehog coreceptor, BOC regulates neuronal differentiation and neurite outgrowth via interaction with ABL and JNK activation. Cellular Signaling, 30, 30-40.
Lee et al., 2016. PKN2 and Cdo interact to activate AKT and promote myoblast differentiation. Cell death & Diseases. 7.
Jeong et al., 2016. Prmt7 deficiency causes reduced skeletal muscle oxidative metabolism and age-related obesity. Diabetes, 65:1868-82.