The immune response monitors and destroys infections and tumors, but at the same time maintains the bodys homeostasis.
When this homeostasis is disrupted, autoimmune diseases and other seemingly immune-related diseases (diabetes mellitus, pulmonary fibrosis, etc.) also occur. B cells are the cells that our laboratory studies centrally, and we conduct research on their regulation and autoantibody secretion regulation. It is generally known that T cells help B cells, but in reality, the complex interaction between these two cells can lead to T cell hyperactivity and T cell-mediated autoimmune diseases. Among B cells, we discovered B-1 helper T cells that help the natural antibody-secreting cell group called B-1 cells, and we are studying their clinical significance and mechanism. These studies mainly use mouse models and at the same time, in collaboration with the clinical field, are conducting studies on the regulation of lymphocytes infiltrating tumors and B cells in autoimmune diseases.