1. Research objective 1: Employment of various biomaterials and biofabrication systems for regenerative medicine purposes.
We aim to fabricate functional hydrogel-based biomimetic tissue substitutes for tissue regenerative applications via the investigation of various biomaterials and biofabrication systems to provide favorable cellular microenvironments for the host cells. Through in vivo assessment in an appropriate animal defect model, the regenerative efficacy of the fabricated tissue substitute will be evaluated.
2. Research objective 2: Development and design of integrative biomanufacturing system for recapitulating stem cell niche in terms of physical/chemical/biological aspects and disease microenvironments including degenerative diseases and muscular dystrophy & various cancers. We aim to design and fabricate novel hydrogel-based 3D tissue constructs with biomimetic and hierarchical architecture for stem cell fate determination, novel co-culture system, and tumor microenvironment (TME) via 3D bioprinting, cell-electrospinning, nano/microfabrication systems and develop functional in vitro disease model platforms as an organ-on-a-chip model and stem cell organoid engineering to modulate cell-cell and cell-matrix interactions for various cellular functions and their subsequent contribution to in vitro tissue model.