SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
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Kyeong Kyu Kim
Kyeong Kyu Kim PhD
| Graduate Program | Data Science and Personalized Medicine/ Infection and Immunity |
| Research Area | Structural Biology/ Regenerative Medicine/ Antimicrobial Resistance/New Therapeutics/Noncanonical DNA |
| Laboratory | Structure Biology Laboratory Laboratory |
| kyeongkyu@skku.edu | |
| Tel | +82-31-299-6136 |
Education & Careers
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2000~Present Professor, Sungkyunkwan University School of Medicine
1998-2000 Assistance professor, Gyeongsang National University
1993-1998 UC Berkeley Post-Doc
1985-1993 Bachelor, Master and PhD Seoul National University (Biochemistry)
Research Interest
Out research goal is to understand the causes of diseases at the molecular level and to develop patient or customized precision therapeutics. We are investigating the biological phenomena or cause of diseases via the interaction of biological molecules such as DNA, protein and metabolites by applying the structural and chemical biology approaches, which allow us to observe the molecules in detail and control their functions. Our main topics are following (1) research on the ubiquitin-dependent protein stability control of cancer related proteins and development of cancer therapeutics targeting ubiquitin pathway (2) understanding the structural and functional roles of the noncanonical DNAs in the genome and their regulation in cancers (3) development of novel antibacterial therapeutics to overcome antibiotic resistance and (4) regenerative medicine research using the patient-specific cell therapies.
Representative Research Achievements
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1. AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.
Hur JH, Kang CY, Lee S, Parveen N, Yu J, Shamim A, Yoo W, Ghosh A, Bae S, Park CJ, Kim KK. Nucleic Acids Res. 2021 Sep 1:gkab728. doi: 10.1093/nar/gkab728
(IF 16.971)
2. An Antibacterial Nanorobotic Approach for the Specific Targeting and Removal of Multiple Drug-Resistant Staphylococcus aureus.
Batool N, Yoon S, Imdad S, Kong M, Kim H, Ryu S, Lee JH, Chaurasia AK, Kim KK. Small. 2021 Apr 10:e2100257. doi: 10.1002/smll.202100257. (IF 13.281)
3. Structural Basis for the Enantioivity of Esterase Est-Y29 toward (S)-Ketoprofen Ngo TD, Oh C, Mizar P, Baek M, Park Ks, Nguyen L, Byeon H, Yoon S, Ryu Y, Ryu BH, Kim TD, Yang JW, Seok C, Lee SS, Kim KK. ACS catalysis 2019 Jan 49(1):755-767. (IF 12.52)
4. Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. Bansal V, De D, An J, Kang TM, Jeong HJ, Kang JS, Kim KK. Biomaterials. 2019 Feb193:30-46. (IF 12.479)
5. Small molecule-induced cellular conversion. De D, Halder D, Shin I, Kim KK. Chem Soc Rev. 2017 Oct 1646(20):6241-6254. (IF 54.564)