SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE

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Kyun-Hwan Kim
Kyun-Hwan Kim PhD
Professor: Graduate Program, Research Area, Laboratory, E-mail, Tel
Graduate Program Infection and Immunity
Research Area Hepatitis B virus, Covid-19
Laboratory Pathogenesis Laboratory Laboratory
E-mail khkim10@skku.edu
Tel +82-31-299-6126
Education & Careers
  • 1985-1991 Seoul National University, Dept. of Chemistry, B.S and M.S
    1991-1999 Lotte Group R&D Center, Senior research scientist
    1997-2002 Yonsei University, Dept. of Biotechnology, PhD
    2003-2005 Brown University, School of Medicine, Post-Doc
    2006-2019 Konkuk University, School of Medicine, Professor
    2020-Now Sungkyunkwan University, School of Medicine, Professor
Research Interest
Hepatitis B virus (HBV) infection causes chronic hepatitis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC). It is a major health problem with over 350 million carriers worldwide.
Influenza, the flu, is an infectious disease caused by an influenza virus. Influenza spreads around the world in a yearly outbreak, resulting in about three to five million cases of severe illness and about 250,000 to 500,000 deaths.
The major topics of current research in my laboratory include: 1) Pathogenesis of viral infection, 2) Host immune escape of virus, 3) virus-induced liver and pulmonary diseases, 4) Development of anti-viral drugs.
Representative Research Achievements
  • 1. Shin GC, Moon SU, Kang HS, et al., & Kim KH*. PRKCSH contributes to tumorigenesis by ive boosting of IRE1 signaling pathway. Nat. Commun. 2019. Jul 1810(1):3185.

    2. Park ES, Byun YH, Park S, et al., & Kim KH*. Co-degradation of interferon signaling factor DDX3 by PB1-F2 as a basis for high virulence of 1918 pandemic influenza. EMBO J. 2019. Apr 12. pii: e99475.

    3. Park ES, Lee AR, Kim DH, et al., & Kim KH*. Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients. J Hepatol. 2019. Feb 19. S0168-8278(19)30120-5.

    4. Kim DH, Park ES, Lee AR, et al., & Kim KH*. Intracellular interleukin-32γ mediates antiviral activity of cytokines against hepatitis B virus. Nat. Commun. 2018. Aug 169(1):3284.

    5. Lee AR, Lim KH, Park ES, et al., & Kim KH*. Multiple functions of cFLIP are essential for replication of hepatitis B virus. J Virol. 2018. Jul 3192(16). pii: e00339-18.

    6. Lim KH, Park ES, Kim DH, et al., & Kim KH*. Suppression of interferon-mediated anti-HBV response by single CpG methylation in the 5-UTR of TRIM22. Gut. 2017. Mar 23. pii: gutjnl-2016-312742.

    7. Shin GC, Kang HS, Lee AR, Kim KH*. Hepatitis B Virus&8211triggered Autophagy Targets Death Receptor 5 for Degradation to Limit TNFSF10/TRAIL Response. Autophagy. 2016. 12 (12):1&821116.

    8. Park YK, Park ES, Kim DH, et al., & Kim KH*. Cleaved c-FLIP mediates the antiviral effect of TNF-<alpha> against hepatitis B virus by dysregulating hepatocyte nuclear factors. J Hepatol. 2016. Feb64(2):268-277.

    9. Ahn SH, Park YK, et al., & Kim KH*. The impact of the hepatitis B virus polymerase rtA181T mutation on replication and drug resistance is potentially affected by overlapping changes in surface gene. J Virol. 2014. 88(12):6805.

    10. Park ES, Park YK, Shin C, et al., & Kim KH*. Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator. Hepatology. 2013.58:762-776.
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