Dongryeol Ryu
Dongryeol Ryu PhD
Professor: Graduate Program, Research Area, Laboratory, E-mail, Tel
Graduate Program Metabolic & Genetic Disease
Research Area Mitochondria, Metabolism, and Aging
Laboratory Molecular and Integrative Biology Lab (MIB) Laboratory
Tel +82-31-299-6138
Education & Careers
  • 2001-2004 B.S. in Mol Biology, Pusan National University
    2004-2006 M.S. in Mol Biology, Pusan National University
    2006-2010 Ph.D. in MCB, SKKU School of Medicine
    2010-2016 Post-doc fellow, EPFL, Switzerland
    2016-2017 Senior Scientist (Preclinical study), Aamzentis SA, Switzerland
    2017-2019 Assistant Professor, Pusan National University
    2019~Prsents Assistant Professor, SKKU School of Medicine
Research Interest
The Ryu Lab is a multidisciplinary research group, exploring to find
(1) the cellular sensors or regulators answering to energy stress and aging,
(2) the retrograde signaling pathways relaying from a stressed organelle to nucleus (e.g. mitonuclear mitochondrial stress signaling),
(3) the gut-metabolic organ axis reshaping on our whole-body energy metabolism, and
(4) the biomolecules and drugs enhancing mitochondrial function and proteostasis. Our challenges will lead to identify and develop translational treatment strategies for metabolic and age-associated diseases.
Our lab prefers to practice a combinational approach of the wet-labs (traditional biochemical & molecular cell biology techniques) and the dry-labs (Bioinformatics).
Representative Research Achievements
  • Publication (Total 56 publications in peer reviewed journals, Total citations > 6.7k, h-index = 32 by July, 2021)

    1. Hwangbo H et al., Bio-printing of aligned GelMa-based cell-laden structure for muscle tissue regeneration. Bioactive Materials. S2452-199X(21)00317-0, 2021

    2. Moon JS et al., Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice, Aging cell. 19(8):e13195, 2020.

    3. Andreux, PA, et al., The mitophagy inducer Urolithin A imparts exercise mimetic like effects on the mitochondria in humans. Nat Metab 1, 595?603, 2019.

    4. Katsyuba E et al., De novo NAD(+) synthesis enhances mitochondrial function and improves health. Nature 563, 354-359, 2018.

    5. Ryu D, et al., NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med 8(361):361ra139, 2016.

    6. Ryu D, et al., Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med 22, 879-888, 2016.

    7. Jo YS, et al., Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015 Nov62(5):1606-18. doi: 10.1002/hep.27907.

    8. Ryu D, et al., A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metab. 2014 Nov 420(5):856-869. doi: 10.1016/j.cmet.2014.08.001.

    9. Ryu D, et al., TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 2009 Mar9(3):240-51. doi:10.1016/j.cmet.2009.01.007.