SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Dongryeol Ryu
Dongryeol Ryu PhD
| Graduate Program | Metabolic & Genetic Disease |
| Research Area | Mitochondria, Metabolism, and Aging |
| Laboratory | Molecular and Integrative Biology Lab (MIB) Laboratory |
| freefall@skku.edu | |
| Tel | +82-31-299-6138 |
Education & Careers
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2001-2004 B.S. in Mol Biology, Pusan National University
2004-2006 M.S. in Mol Biology, Pusan National University
2006-2010 Ph.D. in MCB, SKKU School of Medicine
2010-2016 Post-doc fellow, EPFL, Switzerland
2016-2017 Senior Scientist (Preclinical study), Aamzentis SA, Switzerland
2017-2019 Assistant Professor, Pusan National University
2019~Prsents Assistant Professor, SKKU School of Medicine
Research Interest
The Ryu Lab is a multidisciplinary research group, exploring to find
(1) the cellular sensors or regulators answering to energy stress and aging,
(2) the retrograde signaling pathways relaying from a stressed organelle to nucleus (e.g. mitonuclear mitochondrial stress signaling),
(3) the gut-metabolic organ axis reshaping on our whole-body energy metabolism, and
(4) the biomolecules and drugs enhancing mitochondrial function and proteostasis. Our challenges will lead to identify and develop translational treatment strategies for metabolic and age-associated diseases.
Our lab prefers to practice a combinational approach of the wet-labs (traditional biochemical & molecular cell biology techniques) and the dry-labs (Bioinformatics).
(1) the cellular sensors or regulators answering to energy stress and aging,
(2) the retrograde signaling pathways relaying from a stressed organelle to nucleus (e.g. mitonuclear mitochondrial stress signaling),
(3) the gut-metabolic organ axis reshaping on our whole-body energy metabolism, and
(4) the biomolecules and drugs enhancing mitochondrial function and proteostasis. Our challenges will lead to identify and develop translational treatment strategies for metabolic and age-associated diseases.
Our lab prefers to practice a combinational approach of the wet-labs (traditional biochemical & molecular cell biology techniques) and the dry-labs (Bioinformatics).
Representative Research Achievements
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Publication (Total 56 publications in peer reviewed journals, Total citations > 6.7k, h-index = 32 by July, 2021)
1. Hwangbo H et al., Bio-printing of aligned GelMa-based cell-laden structure for muscle tissue regeneration. Bioactive Materials. S2452-199X(21)00317-0, 2021
2. Moon JS et al., Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice, Aging cell. 19(8):e13195, 2020.
3. Andreux, PA, et al., The mitophagy inducer Urolithin A imparts exercise mimetic like effects on the mitochondria in humans. Nat Metab 1, 595?603, 2019.
4. Katsyuba E et al., De novo NAD(+) synthesis enhances mitochondrial function and improves health. Nature 563, 354-359, 2018.
5. Ryu D, et al., NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med 8(361):361ra139, 2016.
6. Ryu D, et al., Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med 22, 879-888, 2016.
7. Jo YS, et al., Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015 Nov62(5):1606-18. doi: 10.1002/hep.27907.
8. Ryu D, et al., A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metab. 2014 Nov 420(5):856-869. doi: 10.1016/j.cmet.2014.08.001.
9. Ryu D, et al., TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 2009 Mar9(3):240-51. doi:10.1016/j.cmet.2009.01.007.