SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Laboratory
Molecular and Integrative Biology Lab (MIB)(분자통합생물학연구실)
Dongryeol Ryu
- Aging and its associated diseases - Mitochondria and cellular senescence - Energy metabolism and Metabolic diseases - Gut microbiota derived metabolites Laboratory
Dongryeol Ryu is an assistant professor at the Sungkyunkwan University (SKKU) School of Medicine (SOM), Suwon, South Korea, where he leads the Molecular and Integrative Biology Laboratory (MIB Lab) since 2019. He received his Ph.D. degrees from in Mol. Cell Biology from SKKU-SOM in 2010, followed by postdoctoral training at EPFL with Prof. Johan Auwerx. He became a faculty member at Pusan National University in 2017.
Much of Prof. Ryu work focused on understanding how internal and external cues regulate the expression of genes governing energy metabolism. His recent work (Nature Med, 2016) has discovered the first-in-class-mitophagy inducer protects from skeletal muscle aging by the elimination of dysfunctional mitochondria. Its second phase of the human clinical trial is ongoing. He published 46 scientific papers in the peer-reviewed journals, and his h-index is 30 (Google scholar on July 08 2020).
The MIB lab has been using integrative biology approaches to reveal mechanisms underlying aging, metabolism, mitochondria, and their related diseases. My laboratory is standing with two columns, basic and translational biomedical studies based on in silico, in vitro, ex vivo, and in vivo models.
Currently, the basic biomedical research part is investigating in roles of Sirt7, one of the longevity factors Sirtuin, and PA2G4, a nucleic acid-binding protein, in aging and metabolic diseases using tissue-specific KO mouse models. The translational biomedical studies are working on discovering drug candidates for age-associated and metabolic diseases. For instance, my is finding molecules modulating mitophagy, which specifically remove dysfunctional mitochondria in cells.
Much of Prof. Ryu work focused on understanding how internal and external cues regulate the expression of genes governing energy metabolism. His recent work (Nature Med, 2016) has discovered the first-in-class-mitophagy inducer protects from skeletal muscle aging by the elimination of dysfunctional mitochondria. Its second phase of the human clinical trial is ongoing. He published 46 scientific papers in the peer-reviewed journals, and his h-index is 30 (Google scholar on July 08 2020).
The MIB lab has been using integrative biology approaches to reveal mechanisms underlying aging, metabolism, mitochondria, and their related diseases. My laboratory is standing with two columns, basic and translational biomedical studies based on in silico, in vitro, ex vivo, and in vivo models.
Currently, the basic biomedical research part is investigating in roles of Sirt7, one of the longevity factors Sirtuin, and PA2G4, a nucleic acid-binding protein, in aging and metabolic diseases using tissue-specific KO mouse models. The translational biomedical studies are working on discovering drug candidates for age-associated and metabolic diseases. For instance, my is finding molecules modulating mitophagy, which specifically remove dysfunctional mitochondria in cells.
1. Moon JS et al., Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice, Aging cell, in press.
2. Andreux, PA, et al., The mitophagy inducer Urolithin A imparts exercise mimetic like effects on the mitochondria in humans. Nat Metab 1, 595&8211603, 2019.
3. Katsyuba E et al., De novo NAD(+) synthesis enhances mitochondrial function and improves health. Nature 563, 354-359, 2018.
4. Ryu D, et al., NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med 8(361):361ra139, 2016.
5. Ryu D, et al., Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med 22, 879-888, 2016.
2. Andreux, PA, et al., The mitophagy inducer Urolithin A imparts exercise mimetic like effects on the mitochondria in humans. Nat Metab 1, 595&8211603, 2019.
3. Katsyuba E et al., De novo NAD(+) synthesis enhances mitochondrial function and improves health. Nature 563, 354-359, 2018.
4. Ryu D, et al., NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med 8(361):361ra139, 2016.
5. Ryu D, et al., Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med 22, 879-888, 2016.
(Tel) +82-(0)31-299-6138,
(Email) freefall@skku.edu