Angiogenesis is implicated in the development of various diseases including cancer. Currently, we are working on the role of various signaling pathways, especially focusing on S6K-mediated pathway, in determining angiogenic behavior within tumor microenvironment for fully understanding angiogenic process during tumor development.
 3-dimensional organoid culture system is emerging as a potent in vitro model for studying various disorders and diseases including cancer. Currently, we are working on development of 3D organoid culture models and their application for studying molecular mechanisms underlying tumor development as well as personalized cancer treatment.
1. Shin J, Lee JC and Baek KH. A single extra copy of Dscr1 improves survival of mice developing spontaneous lung tumors through suppression of tumor angiogenesis. Cancer Lett. 2014. 342(1):70-81.
7. Lee JC, Shin J and Baek KH. Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras. Biochem. Biophys. Res. Commun. 2013. 440(1):50-55.
3. Shin J, Yang J, Lee JC and Baek KH. Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence. Cell. Signal. 2013. 25(12).2540-2547.
4. Baek KH, Bhang D, Zaslavsky A, Wang LC, Vachani A, Kim CF, Albelda SM, Evan GI and Ryeom S. Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors. J. Clin. Invest. 2013. 123(10): 4375-4389.