The immune response monitors and destroys infections and tumors, but at the same time maintains the bodys homeostasis.
When this homeostasis is disrupted, autoimmune diseases and other seemingly immune-related diseases (diabetes mellitus, pulmonary fibrosis, etc.) also occur. B cells are the cells that our laboratory studies centrally, and we conduct research on their regulation and autoantibody secretion regulation. It is generally known that T cells help B cells, but in reality, the complex interaction between these two cells can lead to T cell hyperactivity and T cell-mediated autoimmune diseases. Among B cells, we discovered B-1 helper T cells that help the natural antibody-secreting cell group called B-1 cells, and we are studying their clinical significance and mechanism. These studies mainly use mouse models and at the same time, in collaboration with the clinical field, are conducting studies on the regulation of lymphocytes infiltrating tumors and B cells in autoimmune diseases.
Lee S, Ko Y, Kim TJ*. Homeostasis and regulation of autoreactive B cells. Cell Mol Immunol 17(6):561-569 (2020)
Liu W, Tolar P, Song W, Kim TJ*. Editorial: BCR Signaling and B Cell Activation. Front Immunol 11:45 (2020)
Lee H, Chung YS, Kim TJ*. Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity. Immune Netw 20(1):e5 (2020)
Zhao X, Xie H, Zhao M, Ahsan A, Li X, Wang F, Yi J, Zhiyong Yang, Wu C, Raman I, Li Q-Z*, Kim TJ*, Liu W*. Fc receptor&8211like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Sci Adv 5(7): eaaw0315 (2019)
Lee M, Park C, Woo J, Kim J, Kho I, Nam D-H, Park W-Y, Kim Y-S, Kong D-S*, Lee HW*, Kim TJ*. Preferential Infiltration of Unique Vγ9Jγ2-Vδ2 T Cells Into Glioblastoma Multiforme. Front Immunol 10:555 (2019)
Park CH, Kim TJ*. Expansion and sub-classification of T cell-dependent antibody responses to encompass the role of innate-like T cells in antibody responses. Immune Netw 18(5):e34 (2018)
Moon H, Lee J-G, Shin SH, Park C, Lee JH, Kang K, Kim TJ*. Early development in the peritoneal cavity of CD49dhigh TH1 memory phenotype CD4+ T cells with enhanced B cell helper activity. J Immunol 195(2):564-575 (2015)