Dr. Kong is a molecular parasitologist interested in fundamental questions of how and why parasites adapt to the sophisticated mammalian immune system and how the parasite exploits their bioactive systems to ensure their long-term survival in the unfavorable host environments. His laboratory focuses on the tissue-invasive helminths that cause fatal outcome in the victims. The central questions his group addresses are (i) which molecules manipulate the host immune system to invoke specific antibody responses? (ii) what parasite molecules are responsible for adaptation into the host? (iii) action mechanism of parasitic bioactive molecules in the host and molecular interaction between parasite molecules and host cells. Most of his publications dealt with these issues. His group has deep interests in characterizing biological and pathophysiological roles of antioxidants and proteolytic enzymes during host-parasite interplay.
1. Ahn CS, Shin JW, Kim JG, Lee WY, Kang I, Im jG, Kong Y. (2020) Spectrum of pleuropulmonary paragonimiasis: An analysis of 685 cases diagnosed over 22 years. J Infect ttps://doi.org/10.1016/j.jinf.2020.09.037
2. Kim JG, Ahn CS, Sripa B, Eom KS, Kang I, Sohn WM, Nawa Y, Kong Y. (2019) Clonorchis sinensis omega-class glutathione transferases are reliable biomarkers for serodiagnosis of clonorchiasis and opisthorchiasis. Clin Microbiol Infect 25(1):109.e1-109.e6.
3. Ahn CS, Kim JG, Shin MH, Lee YA, Kong Y. (2018) Comparison of secretome profile of pathogenic and non-pathogenic Entamoeba histolytica. Proteomics 18(7):e170034.1
4. Ahn CS, Kim JG, Han X, Bae YA, Park WJ, Kang I, Wang H, Kong Y. (2017) Biochemical characterization of Echinococcus multilocularis antigen B3 reveals insight into adaptation and maintenance of parasitic homeostasis at the host-parasite interface. J Proteome Res 16(2):806-823.
5. Kim JG, Ahn CS, Kim SH, Bae YA, Kwon NY, Kang I, Yang HJ, Sohn WM, Kong Y. (2016) Clonorchis sinensis omega-class glutathione transferases play major roles in the protection of the reproductive system during maturation and the response to oxidative stress. Parasite Vectors 9:337.
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