The main pathological features common to obesity and diabetes are the deregulation of nutrient and energy homeostasis. Studying the signaling pathways involved in nutrient and energy homeostasis could lead to better understanding of pathophysiology of metabolic disorders. We are interested in understanding how cells sense and integrate signals from growth factors and from nutrients to mediate metabolic responses, and how such signaling pathway is deregulated in pathological conditions. Integrating the use of biochemistry, molecular biology, mouse model and patient samples, we aim to define deregulation of signaling pathway that may lead to impairment of nutrient and energy homeostasis. This body of work will provide a physiological basis to identify molecular targets with great potential value in the development of therapeutic strategies to treat metabolic disorders. Sung Hee Um was awarded TJ Park Science Fellowship from POSCO TJ Park foundation, and a grant from Samsung science & technology Foundation.
1. Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-Catenin Expression.
Im DU, Kim SC, Chau GC, Um SH*, 2019: Cells, 8(11), 1460-1474
2. Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling.
Son SW, Chau GC, Kim ST and Um SH*, 2019: Cells, 8(10), 1137-1152
3. A single extra copy of Down syndrome critical region 1-4 results in impaired hepatic glucose homeostasis.
Seo DS, Chau GC, Baek KH, Um SH*, 2019: Mol Metab., 21, 82-89
4. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress.
Chau GC, Im DU, Kang TM, Bae JM, Kim W, Pyo S, Moon EY, Um SH*.
J Cell Biol. 2017 Jul 3216(7):2091-2105.
5. S6K1 controls pancreatic β cell size independently of intrauterine growth restriction.
Um SH*, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tsch&246p MH, Thomas G, Kozma SC.
J Clin Invest. 2015 Jul 1125(7):2736-47.
6. S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver.
Kim K, Pyo S, Um SH*.
Hepatology. 2012 Jun55(6):1727-37.