SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
1) Mechanism of dopaminergic neuronal death
2) Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
3) Relationship between neurodegeneration and liquid-liquid phase separation
4) Functional studies of protein lipidation
Laboratory
1) Mechanism of dopaminergic neuronal death
2) Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
3) Relationship between neurodegeneration and liquid-liquid phase separation
4) Functional studies of protein lipidation
Hojin Kang, Areum Jo, Hyein Kim, Rin Khang, Ji-Yeong Lee, Hanna Kim, Chi-Hu Park, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shin* (2018) PARIS reprograms glucose metabolism by HIF-1α induction in dopaminergic neurodegeneration. Biochemical and Biophysical Research Communications, 495(4), 2498-2504.&160
Hyein Kim, Hojin Kang, Yunjong Lee, Chi-Hu Park, Areum Jo, Rin Khang, Joo-Ho Shin* (2017) Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and Biophysical Research Communications, 493(2), 1050-1056.&160
Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee* and Joo-Ho Shin* (2017) Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget, 8(30), 48603-48618.&160
Y Lee, DA. Stevens, S-U Kang, H Jiang, Y-I Lee, HS Ko, LA. Scarffe, GE. Umanah, H Kang, S Ham, T-I Kam, K Allen, S Brahmachari, JW Kim, S Neifert, SP Yun, FC. Fiesel, W Springer, VL. Dawson*, J-H Shin*, TM. Dawson* (2017) PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Report, 18(4), 918-932.&160
Yun-Il Lee, Hojin Kang, Young Wan Ha, Ki-Young Chang, Sung-Chun Cho, Sang Ok Song, Hyein Kim, Areum Jo, Rin Khang, Jeong-Yun Choi, Yunjong Lee, Sang Chul Park, Joo-Ho Shin* (2016) Diaminodiphenyl sulfone&8211induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiology of Aging, 41, 1-10.
Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin* and Ted M. Dawson* (2015) Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America, 112(37), 11696-11701 *Corresponding author
&9642Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, DawsonVL, Shin JH*, Dawson TM*. PINK1 primes parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival. Cell Reports (2017) 18(4):918-932 *Co-corresponding author
&9642Ham S, Lee YI, Jo M, Kim H, Kang H, Jo A, Lee GH, Mo YJ, Park SC, Lee YS, Shin JH*, Lee Y*. Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinsons disease model. Sci Rep. (2017) 7(1):525 *Co-corresponding author
&9642Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget (2017) 8(30):48603-48618
Hyein Kim, Hojin Kang, Yunjong Lee, Chi-Hu Park, Areum Jo, Rin Khang, Joo-Ho Shin* (2017) Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and Biophysical Research Communications, 493(2), 1050-1056.&160
Hojin Kang, Rin Khang, Sangwoo Ham, Ga Ram Jeong, Hyojung Kim, Minkyung Jo, Byoung Dae Lee, Yun Il Lee, Areum Jo, ChiHu Park, Hyein Kim, Jeongkon Seo, Sun Ha Paek, Yun-Song Lee, Jeong-Yun Choi, Yunjong Lee* and Joo-Ho Shin* (2017) Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget, 8(30), 48603-48618.&160
Y Lee, DA. Stevens, S-U Kang, H Jiang, Y-I Lee, HS Ko, LA. Scarffe, GE. Umanah, H Kang, S Ham, T-I Kam, K Allen, S Brahmachari, JW Kim, S Neifert, SP Yun, FC. Fiesel, W Springer, VL. Dawson*, J-H Shin*, TM. Dawson* (2017) PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Report, 18(4), 918-932.&160
Yun-Il Lee, Hojin Kang, Young Wan Ha, Ki-Young Chang, Sung-Chun Cho, Sang Ok Song, Hyein Kim, Areum Jo, Rin Khang, Jeong-Yun Choi, Yunjong Lee, Sang Chul Park, Joo-Ho Shin* (2016) Diaminodiphenyl sulfone&8211induced parkin ameliorates age-dependent dopaminergic neuronal loss. Neurobiology of Aging, 41, 1-10.
Daniel A. Stevens, Yunjong Lee, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Aaron Bower, Haisong Jiang, Sung-Ung Kang, Shaida A. Andrabi, Valina L. Dawson, Joo-Ho Shin* and Ted M. Dawson* (2015) Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proceedings of the National Academy of Sciences of the United States of America, 112(37), 11696-11701 *Corresponding author
&9642Lee Y, Stevens DA, Kang SU, Jiang H, Lee YI, Ko HS, Scarffe LA, Umanah GE, Kang H, Ham S, Kam TI, Allen K, Brahmachari S, Kim JW, Neifert S, Yun SP, Fiesel FC, Springer W, DawsonVL, Shin JH*, Dawson TM*. PINK1 primes parkin-mediated ubiquitination of PARIS in dopaminergic neuronal survival. Cell Reports (2017) 18(4):918-932 *Co-corresponding author
&9642Ham S, Lee YI, Jo M, Kim H, Kang H, Jo A, Lee GH, Mo YJ, Park SC, Lee YS, Shin JH*, Lee Y*. Hydrocortisone-induced parkin prevents dopaminergic cell death via CREB pathway in Parkinsons disease model. Sci Rep. (2017) 7(1):525 *Co-corresponding author
&9642Kang H, Khang R, Ham S, Jeong GR, Kim H, Jo M, Lee BD, Lee YI, Jo A, Park C, Kim H, Seo J, Paek SH, Lee YS, Choi JY, Lee Y, Shin JH. Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic neuroprotection. Oncotarget (2017) 8(30):48603-48618
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(Email) jshin24@skku.edu