SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE

Research Highlights

Preferred endocytosis of amyloid precursor protein from cholesterol-enriched lipid raft microdomains Yoon Young Cho, Oh-Hoon Kwon, Sungkwon Chung Molecules
Date 2022-05-10 Inquiries 28
Effects of Long-Term In Vitro Expansion on Genetic Stability and Tumor Formation Capacity of Stem Cells Hyun Nam, In-Hee Lee, Jason K Sa , Sung Soo Kim, Hee-Jang Pyeon, Kee Hang Lee, Kyunghoon Lee, Sun-Ho Lee, Kyeung Min Joo Stem Cell Rev Rep .
Date 2022-03-22 Inquiries 94
The Pellino1-PKCθ signaling axis is an essential target for improving antitumor CD8+ T lymphocyte function Jihyun Park, Si-Yeon Lee, Yoon Jeon, Kyung-Mo Kim, Jin-Kwan Lee, Jiwon Ko, Eun-Ji Park, Joon-Sup Yoon, Baeki E. Kang, Dongryeol Ryu, Ho Lee, Su-Jin Shin, Heounjeong Go, and Chang-Woo Lee CANCER IMMUNOLOGY RESEARCH
Date 2022-03-18 Inquiries 74
Human Cytomegalovirus UL48 Deubiquitinase Primarily Targets Innermost Tegument Proteins pp150 and Itself To Regulate Their Stability and Protects Virions from Inclusion of Ubiquitin Conjugates Ki Mun Kwon, Young Eui Kim, Myoung Kyu Lee, Woo-Chang Chung, Seokhwan Hyeon, Minji Han, Dajeong Lee, Shuang Gong, Jin-Hyun Ahn Journal of Virology
Date 2022-03-18 Inquiries 51
Analysis of novel drug resistant human cytomegalovirus DNA polymerase mutations reveals the role of a DNA binding loop in phosphonoformic acid resistance Kye Ryeong Park, Young-Eui Kim, Amen Shamim, Shuang Gong, Soo-Han Choi, Kyeong Kyu Kim, Yae-Jean Kim, and Jin-Hyun Ahn FRONTIERS IN MICROBIOLOGY
Date 2022-03-18 Inquiries 43
Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice Inwoo Hwang , Byeong-Seong Kim, Hyo Rim Ko, Seongbong Cho, Ho Yun Lee , Sung-Woo Cho , Dongryeol Ryu , Sungbo Shim , Jee-Yin Ahn MOLECULAR PSYCHIATRY
Date 2022-03-18 Inquiries 44
PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through beta-catenin dysregulation Byeong-Yun Ahn, Myong-Ho Jeong, Jung-Hoon Pyun, Hyeon-Ju Jeong, Tuan Anh Vuong, Ju-Hyeon Bae, Subin An, Su Woo Kim, Yong Kee Kim, Dongryeol Ryu, Hyun-Ji Kim, Hana Cho, Gyu-Un Bae, Jong-Sun Kang CELLULAR AND MOLECULAR LIFE SCIENCES
Date 2022-03-18 Inquiries 41
Engineering “cell-particle hybrids” of pancreatic islets and bioadhesive FK506-loaded polymeric microspheres for local immunomodulation in xenogeneic islet transplantation Tiep Tien Nguyen, Tung Thanh Pham, Hanh Thuy Nguyen, Mahesh Raj Nepal, Cao Dai Phung, Zhiwei You, Nikita Katila, Nirmala Tillija Pun, Tae Cheon Jeong, Dong-Young Choi, Pil-Hoon Park, Chul Soon Yong, Jong Oh Kim, Simmyung Yook,*, Jee-Heon Jeong,* Biomaterials
Date 2022-03-17 Inquiries 44
PARIS farnesylation prevents neurodegeneration in models of Parkinsons disease Areum Jo, Yunjong Lee, Tae-In Kam, Sung-Ung Kang, Stewart Neifert, Senthilkumar S. Karuppagounder, Rin Khang, Hojin Kang, Hyejin Park, Shih-Ching Chou, Sungtaek Oh, Haisong Jiang, Deborah A. Swing, Sangwoo Ham, Sheila Pirooznia, George K. E. Umanah, Xiaobo Mao, Manoj Kumar, Han Seok Ko, Ho Chul Kang, Byoung Dae Lee, Yun-Il Lee, Shaida A. Andrabi, Chi-Hu Park, Ji-Yeong Lee, Hanna Kim, Hyein Kim, Hyojung Kim, Jin Whan Cho, Sun Ha Paek, Chan Hyun Na, Lino Tessarollo, Valina L. Dawson, Ted M. Dawson, Joo-Ho Shin SCIENCE TRANSLATIONAL MEDICINE
Date 2022-03-17 Inquiries 44
Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration. Kim H, Shin JY, Jo A, Kim JH, Park S, Choi JY, Kang HC, Dawson VL, Dawson TM, Shin JH, Lee Y. BRAIN
Date 2022-03-17 Inquiries 45
Mammalian Ssu72 phosphatase preferentially considers tissue-specific actively transcribed gene expression by regulating RNA Pol II transcription Hyun-Soo Kim, Yoon Jeon, Yoon Ok Jang, Ho Lee, Yong Shin, Chang-Woo Lee THERANOSTICS
Date 2022-03-17 Inquiries 37
Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma Hyun-Soo Kim, Joon-Sup Yoon, Yoon Jeon, Eun-Ji Park, Jin-Kwan Lee, Si Chen, Ho Lee, Jee Young Park, Heounjeong Go and Chang-Woo Lee CELL DEATH AND DIFFERENTIATION
Date 2022-03-17 Inquiries 38
Human Cytomegalovirus UL48 Deubiquitinase Primarily Targets Innermost Tegument Proteins pp150 and Itself To Regulate Their Stability and Protects Virions from Inclusion of Ubiquitin Conjugates Ki Mun Kwon, Young Eui Kim, Myoung Kyu Lee, Woo-Chang Chung, Seokhwan Hyeon, Minji Han, Dajeong Lee, Shuang Gong, Jin-Hyun Ahn JOURNAL OF VIROLOGY
Date 2022-03-17 Inquiries 37
Synthetic lethality-mediated precision oncology via the tumor transcriptome 이주상 교수(교신저자/제1저자/성균관대학교), 정영민/김다솔 (공동저자/성균관대학교) CELL
Date 2022-03-17 Inquiries 39
Optimal Preclinical Conditions for Using Adult Human Multipotent Neural Cells in the Treatment of Spinal Cord Injury Jeong-Seob Won,Je Young Yeon,Hee-Jang Pyeon,Yu-Jeong Noh,Ji-Yoon Hwang,Chung Kwon Kim,Hyun Nam,Kyung-Hoon Lee,Sun-Ho Lee,Kyeung Min Joo
Date 2021-05-20 Inquiries 570
Population Response to Air Pollution and the Risk of Coronavirus Disease in Chinese Cities during the Early Pandemic Period. Miryoung Yoon, Kim, Jong-Hun Kim, Jisun Sung, Ah-Young Lim, Myung-Jae Hwang, Eun-Hye Kim, Hae-Kwan Cheong. International Journal of Environmental Research and Public Health. 2021; 18(5):2248. DOI: 10.3390/ijerph18052248
Date 2021-05-20 Inquiries 364
An Antibacterial Nanorobotic Approach for the Specific Targeting and Eradication of Multiple Drug-Resistant Staphylococcus aureus 김경규 교수(교신저자/성균관대학교), 이정헌 (교신저자/성균관대학교) 아킬리쉬 차우라시아 (AkhileshK.Chaurasia) 박사(교신저자/성균관대학교), 나얍바뚤 (Nayab Batool) 박사 (제 1저자/성균관대학교)
Date 2021-05-20 Inquiries 400
Effects of mechanical ventilation on indoor air quality and occupant health status in energy-efficient homes A longitudinal field study Ah-Young Lim 1, Miryoung Yoon 1, Eun-Hye Kim 1, Hyun-Ah Kim 2, Myoung Ju Lee 2, Hae-Kwan Cheong 3 Sci Total Environ . 2021 Apr 26;785:147324. doi: 10.1016/j.scitotenv.2021.147324. Online ahead of print.
Date 2021-05-20 Inquiries 404
Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells Jin-Kwan Lee, Seo-Young Koo, Hye-Mi Nam, Jee-Boong Lee, Jiwon Ko, Kyung-Mo Kim, Eun-Ji Park, Tae Jin Kim, Ho Lee, Heounjeong Go & Chang-Woo Lee Cellular & Molecular Immunology
Date 2021-05-20 Inquiries 480
Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death Hyojung Kim, Jisoo Park, Hojin Kang, Seung Pil Yun, Yun-Song Lee, Yun-Il Lee, and Yunjong Lee Science Signaling 22 Dec 2020: Vol. 13, Issue 663, eaax7119. DOI: 10.1126/scisignal.aax7119
Date 2020-12-23 Inquiries 964
Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion 이연종 Sci Transl Med. 2020 Nov 11;12(569):eaax0091. doi: 10.1126/scitranslmed.aax0091.PMID: 33177178
Date 2020-12-14 Inquiries 825
Anti-tumor effects of anti-PD-1 antibody, pembrolizumab, in humanized NSG PDX mice xenografted with dedifferentiated liposarcoma. Choi B, Lee JS, Kim SJ, Hong D, Park JB, Lee KY.. Cancer Lett. 2020 May 28;478:56-69. doi: 10.1016/j.canlet.2020.02.042
Date 2020-09-15 Inquiries 927
Hepatic expression of Lipopolysaccharide Binding Protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity. Molinaro A*, Koh A*, Wu H, Schoeler M, Faggi I, Carreras A, Hallén A, Bäckhed F, Caesar R. Mol Metab. 2020 Apr 16. (*Co-first authors).
Date 2020-07-22 Inquiries 691
From Association to Causality the Role of the Gut Microbiota and Its Functional Products on Host Metabolism. Koh A*, Bäckhed F*. Mol Cell. 2020 Published online in Mar 31. (*Co-corresponding authors)
Date 2020-07-22 Inquiries 853
PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors Seul-Yi Lee, Tuan Anh Vuong, Hyun-Kyung So, Hyun-Ji Kim, Yoo Bin Kim, Jong-Sun Kang, Ilmin Kwon & Hana Cho Experimental & Molecular Medicine volume 52, pages604–614(2020)
Date 2020-07-22 Inquiries 907
p62 is Negatively Implicated in the TRAF6-BECN1 Signaling Axis for Autophagy Activation and Cancer Progression by Toll-Like Receptor 4 (TLR4). Kim MJ, Min Y, Im JS, Son J, Lee JS, Lee KY. Cells. 2020 May 6;9(5). pii: E1142. doi: 10.3390/cells9051142
Date 2020-07-22 Inquiries 940
Entecavir-resistant hepatitis B virus decreases surface antigenicity A full genome and functional characterization. Park S1, Park ES1, Koo JE2, Park YK1, Lee AR1, Dezhbord M1, Cho ES1, Ahn SH1, Kim DH1, Lee JH3, Lee HC2, Kim KH1,4 Liver Int. 2020 Mar 25. doi: 10.1111/liv.14446.
Date 2020-07-22 Inquiries 615
Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1 +/&8722; Mice Inwoo Hwang1,2 and Jee-Yin Ahn1,2,3,* Int. J. Mol. Sci. 2020, 21(7), 2609;
Date 2020-07-22 Inquiries 915
Analysis of Phototoxin Taste Closely Correlates Nucleophilicity to Type 1 Phototoxicity Eun Jo Du1,3, Tae Jung Ahn1, Hwajin Sung1, HyunJi Jo1, Hyung-Wook Kim4, Seong-Tae Kim2, KyeongJin Kang1,3* PNAS June 11, 2019 116 (24) 12013-12018; first published May 28, 2019
Date 2020-07-03 Inquiries 800