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전임교수

  • 분자종양학 및 종양면역학
  • (전화) 031-299-6121 / (fax)
  • cwlee1234@skku.edu

    주요경력

    • 2012-present Sungkyunkwan University School of Medicine (Professor)
      2010-present Samsung Advanced Institute for Health Sciences and Technology (Professor)
      2006-2012 Sungkyunkwan University School of Medicine (Associate Professor)
      2002-2006 National Cancer Center (Senior Research Associate)
      1998-2000 Harvard Medical School (Post-doctoral fellow)
      1994-1998 University of Glasgow (UK) / National Institute for Medical Research (Ph.D.)

    주요관심연구

    • 1. 종양면역(tumor immunity), 면역체크포인트(immune checkpoint) 및 자가면역(autoimmunity)의 새로운 조절 기전 및 병인 기전 연구
      : 종양면역에서 핵심적인 T 세포의 exhaustion 및 anergy 을 조절하는 새로운 분자기전을 연구팀에서 독자적으로 구축한 다양한 conditional knock-out (KO) 및 transgenic (Tg) 마우스를 활용하여 종양면역의 새로운 분자기전을 제시하고 진단 및 치료기술을 개발하고자 함.

      2. 저분자화합물 및 항체를 이용한 혈액암, 림프종 및 자가면역질환의 치료기술 개발
      : 본 연구팀에서 새롭게 발굴한 저분자화합물과 항체를 연구팀에서 구축한 다양한 종양 마우스 모델과 자가면역질환 마우스 모델에서 후보 치료물질에 의한 치료 효능의 검증, 작용 기전 및 독성 분석을 수행함.

      3. 연구실에서 발굴한 Ssu72 (dual protein phosphatase)와 새로운 타입의 Pellino1 (ubiquitin E3 ligase)에 의한 질병의 새로운 발병 기전 및 치료의 분자표적에 대한 연구를 수행함
      : 본 연구팀에서 구축한 다양한 종류의 conventional Tg, inducible Tg, conditional Tg mice 그리고 KO과 conditional KO mice을 이용하여 Ssu72와 Pellino 1 각각의 gain-of-function과 loss-of-function에 의한 질병화의 새로운 분자기전 및 치료기술에 대해서 연구함. 연구팀에서는 15종류 이상의 마우스를 활용하여 다양한 종류의 T 세포(CD4+, CD8+, Treg 및 Th17 cells), B 세포, microphage, adipocyte, hepatocyte, stem cell, keratinocyte, oval cell 등의 새로운 세포기능 및 관련된 질병에 대해서 연구함.


    대표연구업적

    • 1. Pellino1 is a double-strand break responsive E3 ligase which is required for reversible ATM activation via NBS1 ubiquitination. Nature Communications 2018 in revision (IF 12.353)

      2. Peli1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Molecular Cell 2018, 7(70):920-935 (IF 14.248).

      3. The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nature Communications 2018, In press (IF 12.353)

      4. Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology 2015, 63(2016): 247-259 (IF 14.079)

      5. Pellino1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. Journal of Clinical Investigation 2014, 124(11): 4976-4988 (IF 13.251)

      6. The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores. Nature Communications 2015, 6(7904):1-14 (IF 12.353)

      7. Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 pateints. Nature Communications 2014, 5(5317):1-14 (IF 12.353)

      8. The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores. Nature Communications 2014, 4588(5):1-13 (IF 12.353)

      9. Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion. Nature Communications 2013, 4(2631): 1-14 (IF 12.353)

      10. Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers. Oncogene 2013, 32(12): 1560-1569 (IF 8.559)

      11. TNKS 1 function at telomere and during mitosis is regulated by Polo-like kinase 1-mediated phosphorylation. Cell Death and Differentiation 2012, 19(2): 321-32 (IF 8.385)

      12. The hsSsu72 phosphatase is a cohesion-binding protein that regulates the resolution of sister chromatid arm cohesion. EMBO Journal 2010, 29(20): 3544-3557 (IF 10.748)

      13. Functional interaction between BubR1 and securin in an APCCdc20-independent manner. Cancer Research 2009, 69(1): 27-36 (IF 9.248)

      14. Mitotic catastrophe is the predominant response to histone acetyltransferase depletion. Cell Death and Differentiation 2009, 16(3): 483-497 (IF 9.284)

      15. p53 activation in response to mitotic spindle damage requires signaling via BubR1-mediated phosphorylation. Cancer Research 2007, 67(15): 7155-7164 (IF 9.284)

      16. STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism. Journal of Immunology 2005, 175(11): 7143-7150

      17. Transcriptional abnormality of hsMAD2 mitotic checkpoint gene is a potential link to hepatocellular carcinogenesis. Cancer Research 2004, 64(23): 8666-8673 (IF 9.284)

      18. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 2004, 4: 483-497 (IF 23.893)

      19. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Nature Review Cancers 2004, 4: 91 (IF 37.912).

      20. Inhibition of histone deacetylase activity increases the chromosomal instability by the aberrant regulation of mitotic checkpoint activation. Oncogene 2003, 22(25): 3853-3858 (IF 8.559)
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