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전임교수

  • 전기생리학, 이온채널, 근육생리학
  • (전화) 031-299-6102 / (fax) 031-299-6129
  • tongmkang@skku.edu

    주요경력

    • 학력
      1988. 2: 서울대학교 수의과대학, 수의학사
      1994. 8: 서울대학교 대학원, 수의학박사 (생리학)

      경력
      1994 – 1995: 단국대학교 의과대학, 조교
      1995 – 1998: 삼성생명과학연구소, 연구원
      1998 – 현재: 성균관대학교 의과대학 생리학교실, 전임강사/조교수/부교수/교수
      2001 – 2003: Visiting Assistant Professor, Department of Physiology, University of Texas Southwestern Medical Center at Dallas, USA
      2006 – 현재: 한국이온통로연구회, 총무
      2006 – 2008: 대한생리학회, 기획간사
      2008 – 2010: 대한생리학회, 감사
      2008 – 현재: 대한생리학회, 학술위원
      2010 – 현재: 대한생리학회, 이사
      2013 – 현재: 대한생리학회, 간행이사
      2011 – 2013: 부편집위원장(Associate Editor), Korean Journal of Physiology & Pharmacology
      2013 – 현재: 편집위원장(Editor-in-Chief), Korean Journal of Physiology & Pharmacology
      2016 – 2017: 편집위원장(Editor-in-Chief), Precision and Future Medicine
      2017 – 현재: 편집위원(Editorial board), Pflügers Archiv-European Journal of Physiology

    주요관심연구

    • 연구분야
      - 이온채널 및 세포칼슘신호(Ion channels & intracellular calcium signaling)
      - 이온채널질환(Channelopathies): 부정맥(arrhythmias), 요실금(OAB/UI), 난청(hearing loss)
      - 이온채널 신약개발 및 hERG 심장독성평가(Ion channel drug discovery & hERG assay)
      - 근육생리학(Muscle Physiology): 심장근(heart), 평활근(smooth muscles), 골격근(skeletal muscles)
      - 인공근육 개발(Development of artificial muscles)


    대표연구업적

    • 대표논문
      1. Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. Biomaterials. (2018) 193:30-46.

      2. Discovery of natural compounds promoting cardiomyocyte differentiation. Stem Cells and Development. 2018 Oct 25. doi: 10.1089/scd.2018.0153.

      3. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep. (2018) 8:16659.

      4. Biomolecule based fiber supercapacitor for implantable device. Nano Energy (2018) 47:385-392.

      5. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J Cell Biol. (2017) 216(7):2091-2105.

      6. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci Rep. (2017) 7:40872.

      7. Bio-inspired hybrid carbon nanotube muscles. Sci Rep. (2016) 6:26687.

      8. TrpA1 regulates defecation of food-borne pathogens under the control of the duox pathway. PLoS Genet. (2016) 12(1):e1005773.

      9. Visceral hypersensitivity and altered colonic motility in type 2 diabetic rat. J Neurogastroenterol Motil. (2015) 21(4):581-8.

      10. Development of cell-based assay system that utilizes a hyperactive channel mutant for high-throughput screening of BK(Ca) channel modulators. J Biotechnol. (2013) 167(1):41-6.

      11. Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer. Cancer Res. (2013) 73(3):1056-62.

      12. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. (2013) 430(2):722-8.

      13. Phosphorylation of Stim1 at serine 575 via netrin-2/Cdo-activated ERK1/2 is critical for the promyogenic function of Stim1. Mol Biol Cell. (2012) 23(7):1376-87.

      14. Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells. Pflugers Arch. (2012) 463(2):309-18.

      15. CD40 co-stimulation inhibits sustained BCR-induced Ca signaling in response to long-term antigenic stimulation of immature B cells. Korean J Physiol Pharmacol. (2011) 15(3):179-87.

      16. Improved quantification of islet transplants by magnetic resonance imaging with Resovist. Pancreas (2011) 40(6):911-9.

      17. Kir3.1 channel is functionally involved in TLR4-mediated signaling. Biochem Biophys Res Commun. (2011) 407(4):687-91.

      18. TNF-alpha inhibits the CD3-mediated upregulation of voltage-gated K+ channel (Kv1.3) in human T cells. Biochem Biophys Res Commun. (2010) 391(1):909-14.

      19. Enhanced actuation of PPy/CNT hybrid fibers using porous structured DNA hydrogel. Sensors and Actuators B (2010) 145:89-92.

      20. Tough supersoft sponge fibers with tunable stiffness from a DNA self-assembly technique. Angew Chem Int Ed Engl. (2009) 48(28):5116-20.

      21. Switchable redox activity by proton fuelled DNA nano-machines. Chem Commun (Camb). (2009) 14(10):1240-2.

      22. Fullerene attachment enhances performance of a DNA nanomachine. Adv. Mater. (2009) 21:1-4.

      23. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metabolism (2008) 8(4)318-324.

      24. DNA-Wrapped single-walled carbon nanotube hybrid fibers for supercapacitors and artificial muscles. Adv. Mater. (2008) 20:466-470.

      25. PKC-Independent Stimulation of Cardiac Na/Ca Exchanger by Staurosporine. Korean J Physiol Pharmacol. (2008) 12(5):259-65.

      26. TRP-independent inhibition of the phospholipase C pathway by natural sensory ligands. Biochem Biophys Res Commun. (2008) 370(2):295-300.

      27. DNA hydrogel fiber with self-entanglement prepared by using an ionic liquid. Angew Chem Int Ed Engl. (2008) 47(13):2470-4.

      28. Arachidonic acid-induced activation of large-conductance potassium channels and membrane hyperpolarization in mouse B cells. Pflugers Arch. (2008) 456(5):867-81.

      29. Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats. World J Gastroenterol. (2008) 14(5):731-6.

      30. Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes. Pflugers Arch. (2008) 456(3):549-60.

      31. Mechanosensitive activation of K+ channel via phospholipase C-induced depletion of phosphatidylinositol 4,5-bisphosphate in B lymphocytes. J Physiol. (2007) 582(Pt 3):977-90.

      32. Actin cytoskeletons regulate the stretch-induced increase of Ca2+ current in human gastric myocytes. Biochem Biophys Res Commun. (2007) 352(2):503-8.

      33. Voltage-dependent slowly activating anion current regulated by temperature and extracellular pH in mouse B cells. Pflugers Arch. (2006) 452(6):707-17.

      34. The high throughput screening of neuropeptide FF2 receptor ligands from Korean herbal plant extracts. Peptides (2006) 27(5):997-1004.

      35. Multiple transport modes of the cardiac Na+/Ca2+ exchanger. Nature (2004) 427(6974):544-548.

      36. Ion fluxes in giant excised cardiac membrane patches detected and quantified with ion-selective microelectrodes. J Gen Physiol (2003) 121:325-347.

      37. The properties of carbachol-activated nonselective cation channels at the single channel level in guinea pig gastric myocytes. Jpn J Pharmacol. (2001) 85(3):291-8.

      38. Caffeine- and histamine-induced oscillations of K(Ca) current in single smooth muscle cells of rabbit cerebral artery. Pflugers Arch. (1995) 431(1):91-100.
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