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전임교수

  • 조교수II의과대학
  • Metabolic & Genetic Disease
  • Data Science and Personalized Medicine
  • 류동렬(Dong Ryeol Ryu)
  • 노화, 대사질환 및 근육질환
  • (전화) 031-299-6138(6314호) / (fax)
  • freefall@skku.edu

    주요경력

    • 2004 부산대학교 분자생물학과, 학사
      2006 부산대학교 분자생물학과, 석사
      2010 성균관대학교 의학과, 분자세포생물학교실, 박사
      2010-2016 스위스 로잔연방공대(EPFL), 박사후연구원
      2016-2017 Amazentis SA, EPFL innovation park, 선임연구원
      2017-2019 부산대학교, 조교수
      2019-현재 성균관대학교 의과대학, 조교수

    주요관심연구

    • - Genes and drugs regulating mitochondrial homeostasis, mitophagy, mitonuclear stress pathway, and mitokines.
      - Gut Microbiota-derived small metabolite, which impacts on metabolism, inflammation, and behavior.
      - Sirtuin Biology: Understanding the pathophysiological role of Sirt7 in the conditional KO mouse and human diseases.


    대표연구업적

    • Publication (Total 37 publications in peer reviewed journals, Total citations > 3.7k, h-index = 25 by April, 2019)
      1. Vannini N, et al., The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. Cell Stem Cell. 2019 Mar 724(3):405-418.e7. doi: 10.1016/j.stem.2019.02.012.

      2. Katsyuba E, et al., De novo NAD(+) synthesis enhances mitochondrial function and improves health. Nature. 2018 Nov563(7731):354-359. doi: 10.1038/s41586-018-0645-6.

      3. Williams EG, et al., Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population. Mol Cell Proteomics. 2018 Sep17(9):1766-1777. doi: 10.1074/mcp.RA118.000554.

      4. Jung SB, et al., Reduced oxidative capacity in macrophages results in systemic insulin resistance. Nat Commun. 2018 Apr 199(1):1551. doi: 10.1038/s41467-018-03998-z.

      5. Kim K, et al., Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis. Gastroenterology. 2017 Dec153(6):1568-1580.e10. doi:10.1053/j.gastro.2017.08.039.

      6. Stein S, et al., Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest. 2017 Feb 1127(2):583-592. doi: 10.1172/JCI85499.

      7. Chung HK et al., Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017 Jan 2216(1):149-165. doi: 10.1083/jcb.201607110.

      8. Ryu D, et al., NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 198(361):361ra139.

      9. Ryu D, et al., Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat Med. 2016 Aug22(8):879-88. doi:10.1038/nm.4132.

      10. Zhang H, et al., NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science. 2016 Jun 17352(6292):1436-43. doi: 10.1126/science.aaf2693.

      11. Gariani K, et al., Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016 Apr63(4):1190-204. doi: 10.1002/hep.28245.

      12. Jo YS, et al., Phosphorylation of the nuclear receptor corepressor 1 by protein kinase B switches its corepressor targets in the liver in mice. Hepatology. 2015 Nov62(5):1606-18. doi: 10.1002/hep.27907.

      13. Ryu D, et al., A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function. Cell Metab. 2014 Nov 420(5):856-869. doi: 10.1016/j.cmet.2014.08.001.

      14. Verbeek J, et al., Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis. Gut. 2015 Apr64(4):673-83. doi:10.1136/gutjnl-2014-306748. (IF =17.016)

      15. Mouchiroud L, et al., The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013 Jul 18154(2):430-41. doi: 10.1016/j.cell.2013.06.016.

      16. Houtkooper RH, et al., Mitonuclear protein imbalance as a conserved longevity mechanism. Nature. 2013 May 23497(7450):451-7. doi: 10.1038/nature12188. (IF =41.577)

      17. Kim DK et al., Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis. J Biol Chem. 2012 Jun 22287(26):21628-39. doi: 10.1074/jbc.M111.315168. (*Co-first authors)

      18. Timmers S, et al., Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011 Nov 214(5):612-22. doi: 10.1016/j.cmet.2011.10.002.

      19. Ryu D et al., Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance. Diabetes. 2011 Apr60(4):1072-81. doi: 10.2337/db10-1046.

      20. Ryu D, et al., TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 2009 Mar9(3):240-51. doi:10.1016/j.cmet.2009.01.007.
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