2000 ~ 2005 서강대학교 생명과학과, 화학과 (학사)
2005 ~ 2013 포항공과대학교 생명과학과 (석박사)
2006 ~ 2007 Stanford University School of Medicine (방문연구원)
2014 ~ 2014 서강대학교 생명과학과 (박사후 연구원)
2014 ~ 2019 University of Gothenburg and Sahlgrenska Hospital (박사후 연구원)
2020 ~ 현재 성균관대학교 의과대학
It is becoming evident that microbiota can directly signal to the host by generating bioactive metabolites, which would contibute to the development (i.e., imidazole propionate) or amelioration of metabolic diseases (i.e., short-chain fatty acids). In our lab, we aim to identify therapeutics for metabolic diseases including diabetes and cancer based on mechanistic understanding of the role of microbial metabolites. In addition, we will investiagte inter-individual variations or failure in drug response in the context of microbial metabolite milieu by using organoids as a model system.
1.Koh A, Molinaro A, Stahlman M, Khan MT, Schmidt C, Manneras-Holm L, Wu H, Carreras A, Jeong H, Olofsson L, Bergh PO, Gerdes V, Hartstra A, Brauw M, Perkins R, Nieuwdorp M, Bergstrom G, Backhed F. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. Cell. 2018 Nov 175 (4): 947-961.
2.Jeong H, Koh A, Lee J, Park D, Lee JO, Lee MN, Jo KJ, Tran HNK, Kim E, Min BS, Kim HS, Berggren PO, Ryu SH. Inhibition of C1-Ten PTPase activity reduces insulin resistance through IRS-1 and AMPK pathways. Sci Rep. 2017 Dec 7 (1): 177777.
3.Lee J, Koh A, Jeong H, Kim E, Ha TS, Saleem MA, Ryu SH. C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation. Sci Rep. 2017 Sep 7(1): 12346.
4.Koh A, Vadder DF, Kovatcheva-Datchary P, Bäckhed F. From dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites. Cell. 2016 Jun 165 (2): 1332-1345.
5.Yunn NO, Koh A, Han S, Lim JH, Park S, Lee J, Kim E, Jang SK, Berggren PO, Ryu SH. Agonistic aptamer to the insulin receptor leads to biased signaling and functional ivity through allosteric modulation. Nucleic Acids Res. 2015 Aug.
6.Koh A, Lee MN, Yang YR, Jeong H, Ghim J, Noh J, Kim J, Ryu D, Park S, Song P, Koo SH, Leslie NR, Berggren PO, Choi JH, Suh PG, Ryu SH. C1-Ten is a protein tyrosine phosphatase of IRS-1, regulating IRS-1 stability and muscle atrophy. Mol. Cell. Biol. 2013 Apr 33(8): 1608-1620.
16419 경기도 수원시 장안구 서부로 2066 (경기도 수원시 장안구 천천동 300) 성균관대학교 의과대학 Tel : 031-299-6021~7 Fax : 031-299-6029
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