SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Jee-Yin Ahn
Jee-Yin Ahn PhD
| Graduate Program | Neuroscience |
| Research Area | Brain Development / Death and Recovery of Neurons |
| Laboratory | Neural Development and Disease Lab Laboratory |
| jeeahn@skku.edu | |
| Tel | +82-31-299-6134 |
Education & Careers
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1995-2000 B.S/M.S/Ph.D. Department of Genetic Engineering, Hallym University
2002-2004 Post-Doctoral Fellow, Emory University School of Medicine, USA.
2011-2012 Visiting Professor, University of California San Francisco (UCSF) School of Medicine.
2005-Present Assistant/Associate/Full Professor, Sungkyunkwan University School of Medicine
Research Interest
Signaling networks regulating cell survival and dynamics in brain development and disease
The goal of our research is to identify the fundamental mechanisms and principles that govern neuronal death and connectivity of neural circuits in the brain development and disease and to determine how these mechanisms are deregulated in neurological diseases. Currently our lab focused on the elucidation of 1) the regulation of neuron death in brain disease, 2) the intrinsic mechanisms regulating the neural development including growth cone formation and synapse function. We are also very interested in 3) neurodevelopment and regeneration control after CNS injury using mouse model.
The goal of our research is to identify the fundamental mechanisms and principles that govern neuronal death and connectivity of neural circuits in the brain development and disease and to determine how these mechanisms are deregulated in neurological diseases. Currently our lab focused on the elucidation of 1) the regulation of neuron death in brain disease, 2) the intrinsic mechanisms regulating the neural development including growth cone formation and synapse function. We are also very interested in 3) neurodevelopment and regeneration control after CNS injury using mouse model.
Representative Research Achievements
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1. Hwang et al., (2022) Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice Molecular Psychiatry 27, 2030-2041
2. Yun et al., (2021) Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin. Cell DeathDis
3. Ko et al.,(2019) Roles of ErbB3 binding protein 1 (EBP1) in embryonic development and gene-silencing control Proc Natl Acad Sci 116 (49) 24852-24860
4. Ko et al.,(2019) SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development. J. Biol. Chem. 294(42):15435-15445
5. Jin et al., (2018) Akt mediates radixin phosphorylation and prevents proteasomal degradation, contributing F-actin binding and axon growth in hippocampal neuron Scientific Reports 8(1):2557
6. Ko et al., (2016)Akt1/Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration eLife 5:e20799
7. Ko et al., (2014), P42 Ebp1 regulates the proteasomal degradation of the p85 regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70/CHIP Cell Death and Dis 5, e1131
8. Lee et al., (2012) S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1/GAPDH death cascade J Cell Biol. 199(1) 65-76
9. Kim et al., , (2010) Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors. Cancer Res 70(23):9730-9741
10. Lee et al., (2008), Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival Proc Natl Acad Sci. 105(43) 16584-16589