SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
Professor
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Jin-Hyun Ahn
Jin-Hyun Ahn PhD
| Graduate Program | Infection and Immunity |
| Research Area | Viral Replication and Virus-host Interaction |
| Laboratory | Laboratory of Molecular Virology Laboratory |
| jahn@skku.edu | |
| Tel | +82-31-299-6222 |
Education & Careers
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1986 Dept. of Microbiology, Seoul National University, BS
1994 Dept. of Microbiology, Seoul National University, Ph.D.
2000 Johns Hopkins Medicine, Post-doc Fellow/ Research Associate
2001 - present. Dept. of Microbiology, Sungkyunkwan University School of Medicine, Assistant Prof./Associate Prof./Prof.
Research Interest
In molecular virology lab, we study the gene functions and host interactions of human cytomegalovirus (HCMV) that causes several diseases in patients with congenital infection and impaired immune function, and Varicella-Zoster virus (VZV) that causes chickenpox and Zoster. The functions of viral regulatory proteins, DNA replication proteins, and tegument proteins in the virus life cycle are studied using molecular biology, cell biology, and genetic analysis methods. Through studies on the defense mechanisms of cells responding to viral infection and on the functions of viral genes that regulate them, we investigate the interaction between viruses and hosts. We also study how to effectively control the infection of these viruses. Recently, we have been actively conducting research on viral regulation of the host innate immunity, the interaction between viral infection and the cellular ubiquitin and ubiquitin-like modification systems, and G-quadruplex functions on viral genomes.
Representative Research Achievements
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1. Park D, Chung WC, Gong S, Ravichandran S, Lee GM, Han M, Kim KK, Ahn JH. (2024) G-quadruplex as an essential structural element in cytomegalovirus replication origin. Nature Commun. 15:7353.
2. Oh SJ, Yu JW, Ahn JH, Choi ST, Park H, Yun J, Shin OS. (2024) Varicella zoster virus glycoprotein E facilitates PINK1/Parkin-mediated mitophagy to evade STING and MAVS-mediated antiviral innate immunity. Cell Death Dis. 15:16.
3. Maria Razzaq, Ji Ho Han, Subramaniyam Ravichandran, Jaehyun Kim, Joon-Yong Bae, Man-Seong Park, Shrute Kannappan, Woo-Chang Chung, Jin-Hyun Ahn*, Moon Jung Song*, and Kyeong Kyu Kim* (2023) Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression. Arch. Pharm. Res. 46(7):598&8211615.
4. Chung WC, Ravichandran S, Park D, Lee GM, Kim YE, Choi Y, Song MJ, Kim KK, Ahn JH. (2023) G-quadruplexes formed by Varicella-Zoster virus reiteration sequences suppress expression of glycoprotein C and regulate viral cell-to-cell spread. PLoS Pathog 19(1): e1011095.
5. Chung WC, Ahn JH, Song MJ. (2023) Liquid-liquid phase separation drives herpesvirus assembly in the cytoplasm. J Cell Biol. 222(1): e202211015.
6. Park KR, Kim YE, Shamim A, Gong S, Choi SH, Kim KK, Kim YJ, Ahn JH. (2022) Analysis of novel drug resistant human cytomegalovirus DNA polymerase mutations reveals the role of a DNA binding loop in phosphonoformic acid resistance. Front. Microbiol. Front. Microbiol. 13:771978.
7. Kwon K, Kim YE, Lee MK, Chung WC, Hyeon S, Han MJ, Lee D, Gong S, Ahn JH. (2021) Human cytomegalovirus UL48 deubiquitinase primarily targets innermost tegument proteins pp150 and itself to regulate their stability and protects virions from inclusion of ubiquitin conjugates. J. Virol. 95(23):e0099121.
8. Yang B, Yao Y, Wu H, Yang H, Ma XH, Li D, Wang XZ, Huang SN, Jiang X, Cheng S, Sun JY, Huang ZL, Zhao CJ, McVoy , Ahn JH, Zeng WB, Britt W, Gong S, Luo MH. (2021) Localization of the WD repeat-containing protein 5 to the virion assembly compartment facilitates human cytomegalovirus assembly. J. Virol. 95(8):e2101-20.
9. Hyeon S, Lee MK, Kim YE, Lee GM, Ahn JH. (2020) Degradation of SAMHD1 restriction factor through Cullin-Ring E3 ligase complexes during human cytomegalovirus infection. Front. Cell. Infect. Microbiol. 10:391.
10. Lee MK, Hyeon S, Ahn JH. (2020) The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50. J. Virol. 94(13):e00110-20.
11. Ravichandran S, Ahn JH*, Kim KK*. (2019) Unraveling the regulatory G-quadruplex puzzle: lessons from genome and transcriptome-wide studies. Frontiers in Genetics. 10:1002.
12. Ravichandran S, Kim YE, Bansal V, Ghosh A, Hur J, Subramani VK, Pradhan S, Lee MK, Kim KK*, Ahn JH*. (2018) Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus. PLoS Pathog. 14(9):e1007334.
13. Lee MK, Kim YJ, Kim YE, Han TH, Milbradt J, Marschall M, Ahn JH. (2018) Transmembrane protein pUL50 of human cytomegalovirus inhibits ISGylation by downregulating UBE1L. J. Virol. 92(15):e00462-18.
14. Kwon KM, Oh SE, Kim YE, Han TH, Ahn JH. (2017) Cooperative inhibition of RIP1-mediated NF-κB signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit. PLoS Pathog 13(6): e1006423
15. Kim YJ, Kim ET, Kim YE, Lee MK, Kwon KM, Kim KI, Stamminger T, Ahn JH. (2016) Consecutive inhibition of ISG15 expression and ISGylation by cytomegalovirus regulators. PLoS Pathog. 12(8):e1005850.
16. Kim YE, Oh SE, Kwon KM, Lee CH, Ahn JH. (2016) Involvement of the N-terminal DUB domain of human cytomegalovirus UL48 tegument protein in auto-ubiquitination, virion stability and virus entry. J. Virol. 90(6):3229-3242.
17. Kim YE. Ahn JH. (2015) Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by cytomegalovirus. PLoS Pathog. 11(3):e1004785.