Jin-Hyun Ahn
Jin-Hyun Ahn PhD
Professor: Graduate Program, Research Area, Laboratory, E-mail, Tel
Graduate Program Infection & Immunity
Research Area Viral Replication and Virus-host Interaction
Laboratory Molecular Virology Lab Laboratory
Tel +82-31-299-6222
Education & Careers
  • 1986 Dept. of Microbiology, Seoul National University, BS
    1994 Dept. of Microbiology, Seoul National University, Ph.D.
    2000 Johns Hopkins Medicine, Post-doc Fellow/ Research Associate
    2001 &8211 present. Dept. of Microbiology, Sungkyunkwan University School of Medicine, Assistant Prof./Associate Prof./Prof.
Research Interest
In molecular virology lab, we study the gene function and interaction with host of human cytomegalovirus (HCMV) that causes several diseases in patients with congenital infections and impaired immune function, and Varicella-Zoster virus (VZV) that causes chickenpox and Zoster. The functions of viral immediate-early regulatory proteins, DNA replication proteins, and tegument proteins are studied using molecular biology, cell biology, and genetic analysis methods. Through studies on the defense mechanisms of cells responding to viral infections and on the functions of viral genes that regulate them, we investigate the interaction between viruses and hosts. We also study how to effectively control the infection of these viruses. Recently, we have been actively conducting research on viral regulation of the host innate immunity, on the mechanisms of virus entry and virion maturation, and on the interaction between viral infection and the cellular ubiquitin and ubiquitin-like modification systems.
Representative Research Achievements
  • 1. Lee MK, Hyeon S, Ahn JH. 2020. The Human Cytomegalovirus Transmembrane Protein pUL50 Induces Loss of VCP/p97 and Is Regulated by a Small Isoform of pUL50. J. Virol. 94(13):e00110-20.

    2. Ravichandran S, Kim YE, Bansal V, Ghosh A, Hur J, Subramani VK, Pradhan S, Lee MK, Kim KK*, Ahn JH*. 2018. Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus. PLoS Pathog. 14(9):e1007334.

    3. Kwon KM, Oh SE, Kim YE, Han TH, Ahn JH. 2017. Cooperative inhibition of RIP1-mediated NF-κB signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit. PLoS Pathog 13(6): e1006423

    4. Kim YJ, Kim ET, Kim YE, Lee MK, Kwon KM, Kim KI, Stamminger T, Ahn JH. 2016. Consecutive inhibition of ISG15 expression and ISGylation by cytomegalovirus regulators. PLoS Pathog. 12(8):e1005850.

    5. Kim YE. Ahn JH. 2015. Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by cytomegalovirus. PLoS Pathog. 11(3):e1004785