SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
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Tong Mook Kang
Tong Mook Kang PhD
| Graduate Program | Neuroscience |
| Research Area | Ion Channels |
| Laboratory | Ion Channel Lab Laboratory |
| tongmkang@skku.edu | |
| Tel | +82-31-299-6102 |
Education & Careers
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1988. 2: D.V.M., Seoul National University College of Veterinary Medicine, Korea
1994. 8: Ph.D., Seoul National University College of Veterinary Medicine, Korea
1995 - 1998: Research Fellow, Samsung Biomedical Research Institute (SBRI), Korea
1998 - present: Instructor/Assistant Prof./Associate Prof./Prof., Department of Physiology, Sungkyunkwan University School of Medicine, Korea
2001 - 2003: Visiting Assistant Prof., Department of Physiology, UT Southwestern Medical Center at Dallas, USA
2006 - present: Secretary General, The Korean Society for Ion Channel Research
2011 - 2013: Associate Editor, Korean J Physiol Pharmacol (KJPP)
2013 - 2023: Editor-in-Chief, Korean J Physiol Pharmacol (KJPP)
2016 - 2017: Editor-in-Chief, Precision and Future Medicine (P&FM)
2017 - present: Editorial Board Member, Pflugers Archiv-European Journal of Physiology
2020 - 2023: Vice Chair, Committee for Evaluation, Korean Association of Medical Journal Editors (KAMJE)
Research Interest
- Ion channels and transporters, Intracellular Ca2+ signaling
- Channelopathy of hearing loss (KCNQ4 channelopathy)
- Cardiac arrhythmias, hERG assay and cardiotoxicity
- Ion channel drug discovery
- Muscle Physiology (Cardiac muscle, Smooth muscle, Skeletal muscle)
- Nano-bionics and artificial muscles
- Channelopathy of hearing loss (KCNQ4 channelopathy)
- Cardiac arrhythmias, hERG assay and cardiotoxicity
- Ion channel drug discovery
- Muscle Physiology (Cardiac muscle, Smooth muscle, Skeletal muscle)
- Nano-bionics and artificial muscles
Representative Research Achievements
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1. Calcium homeostasis modulator 2 (Calhm2) as slowly activating membrane current channel in mouse B cells. Biochem Biophys Res Commun (2024) 699:149561
2. The three muscle layers in the pyloric sphincter and their possible function during antropyloroduodenal motility. Sci Rep. (2021) 11(1):20094.
3. Biomimetic cell-actuated artificial muscle with nanofibrous bundles. Microsyst Nanoeng. (2021) 7:70.
4. Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss. Exp Mol Med. (2021) 53(7):1192-1204.
5. Identification and characterization of a novel large-conductance calcium-activated potassium channel activator, CTIBD, and its relaxation effect on urinary bladder smooth muscle. Mol Pharmacol. (2021) 99(2):114-124.
6. Targeted epigenetic modulation using a DNA-based histone deacetylase inhibitor enhances cardiomyogenesis in mouse embryonic stem cells. J Cell Physiol. (2021) 236(5):3946-3962.
7. Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane. Korean J Physiol Pharmacol. (2020) 24(6):529-543.
8. Two-Ply Carbon Nanotube Fiber-Typed Enzymatic Biofuel Cell Implanted in Mice. IEEE Trans Nanobioscience. (2020) 19(3):333-338.
9. Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes. Korean J Physiol Pharmacol. (2019) 23(6):539-547.
10. Unconventional eNOS in pulmonary artery smooth muscles: why should it be there? Pflugers Arch. (2019) 471(10):1245-1246.
11. Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells. Biomaterials. (2019) 193:30-46
12. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep. (2018) 8:16659.
13. Discovery of Natural Compounds Promoting Cardiomyocyte Differentiation. Stem Cells Dev. (2019) 28(1):13-27.
14. Biomolecule based fiber supercapacitor for implantable device. Nano Energy (2018) 47:385-392.
15. mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J Cell Biol. (2017) 216(7):2091-2105.
16. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci Rep. (2017) 7:40872.
17. Bio-inspired hybrid carbon nanotube muscles. Sci Rep. (2016) 6:26687.