Kwan Soo Ko
Kwan Soo Ko PhD
Professor: Graduate Program, Research Area, Laboratory, E-mail, Tel
Graduate Program Infection and Immunity
Research Area Antimicrobial Resistance
Laboratory Antimicrobial Resistant Pathogen Research Lab Laboratory
Tel +82-31-299-6155
Education & Careers
  • 2007~Present Professor, Sungkyunkwan University School of Medicine, Suwon, Korea
    2000-2007 Chief Research Associate, Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, Korea
    2000-2003 Post-doc, Seoul National University College of Medicine, Seoul, Korea
    1996-2000 PhD, Department of Microbiology, Seoul National University, Seoul, Korea
    1994-1996 MS, Department of Microbiology, Seoul National University, Seoul, Korea
    1990-1994 BS, Seoul National University, Seoul, Korea
Research Interest
The target bacteria that we are studying are Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumonia, Enterobacter sp. and Stenotrophomonas maltophilia, and we’ve been conducting research on colistin and carbapenem resistance against those target bacteria. Especially, I’m anticipating the results from research such as the colistin-dependent A. baumannii, the reversal mechanism of colistin resistance in P. aeruginosa, persisters in A. baumannii and the various pathways to colistin resistance in K. pneumoniae. However, the results do not always draw from what was expected. I keep thinking about the fact that really beneficial and important research can come out from anywhere. That is why the minor studies that graduate students are conducting, which look as if they are not very important, can produce incredible results later. I hope that my research can help researchers in this field to understand antibiotic resistance mechanisms. A firm understanding of the mechanism can postpone the emergence of antibiotic resistance and prevent the bacteria from spreading. Also the development of new classes of antibiotics is essential. It is impossible to know how much I can contribute to this research field, but I will keep doing my research as if I’m laying down the stepping stones towards a major discovery.
Representative Research Achievements
  • 1. Hong YK†, Kim H†, Ko KS*. Two types of colistin heteroresistance in Acinetobacter baumannii isolates. Emerging Microbes & Infections 2020 9(1): 2114-2123.

    2. Baek MS, Chung ES, Jung DS, Ko KS*. Effect of colistin-based antibiotic combinations on the eradication of persister cells in Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 2020 75(4):917-924.

    3. Lee H, Shin J, Chung YJ, Park M, Kang KJ, Baek JY, Shin D, Chung DR, Peck KR, Song JH, Ko KS*. Co-introduction of plasmids harbouring the carbapenemase genes, blaNDM-1 and blaOXA-232, increases fitness and virulence of bacterial host. Journal of Biomedical Science 2020 27:8.

    4. Lee JY, Lee H, Park M, Cha CJ, Shin D Ko KS*. Lytic transglycosylase contributes to the survival of lipooligosaccharide (LOS)-deficient, colistin-dependent Acinetobacter baumannii. Clinical Microbiology and Infection 2019 25(9):1156.e1&82111156.e7.

    5. Chung ES, Ko KS*. Eradication of persister cells of Acinetobacter baumannii through combination of colistin and amikacin antibiotics. Journal of Antimicrobial Chemotherapy 2019 74(5):1277-1283.