SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Chang-Woo Lee
Chang-Woo Lee PhD
| Graduate Program | Cancer Biology |
| Research Area | Molecular Oncology, Tumor Immunology, autoimmunity |
| Laboratory | Molecular Tumor Immunology Laboratory Laboratory |
| cwlee1234@skku.edu | |
| Tel | +82-31-299-6121 |
Education & Careers
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1982-1986 B.S. in Life Science, Pusan National University, Korea
1991-1994 Research Assistant, Dept. of Life Science, POSTECH, Korea
1994-1998 Ph.D. in Cell Biology, University of Glasgow/National Institute for Medical Research, UK (Supervisor, Prof. Nick La Thangue)
1998-2000 Postdoctoral Research Fellow, Dept. of Cell Biology, Harvard Medical School, USA (Supervisor, Prof. Frank McKeon)
2000-2002 Research Professor, Div. of Molecular and Life Science, POSTECH, Korea
2002-2005 Senior Research Associate, Liver and Pancreatobiliary Cancer Branch, Research Institute, National Cancer Center, Korea
2006-2011 Associate Professor, Department of Molecular Cell Biology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Korea
2012-present Professor, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Korea
2010-present Professor, Division of Molecular Medicine, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Korea
Research Interest
1. Tumor biology and Anti-tumor immunity
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity and autoimmune disease therapy
: Receptor-mediated signaling mechanism in regulating autoimmunity and the development of autoimmune disease therapeutic strategy
3. Hepatic metabolic disorders and hepatocellular carcinoma
: Study of novel molecular mechanism of steatohepatitis and hepatocellular carcinoma, and development of its relevant therapeutic strategy
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity and autoimmune disease therapy
: Receptor-mediated signaling mechanism in regulating autoimmunity and the development of autoimmune disease therapeutic strategy
3. Hepatic metabolic disorders and hepatocellular carcinoma
: Study of novel molecular mechanism of steatohepatitis and hepatocellular carcinoma, and development of its relevant therapeutic strategy
Representative Research Achievements
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1. Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, and Lee CW. Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nature Communications, 2023, 14: 1097. (IF 17.694)
2. Park J, Lee SY, Jeon Y, Kim KM, Lee JK, ko J, Park EJ, Yoon JS, kang BE, Ryu D, Lee H, Shin SJ, Go H, and Lee CW. The Pellino1-PKCθ signaling axis is an essential target for improving antitumor CD8+ T-lymphocyte function. Cancer Immunology Research, 2022, 10(3):327-342. (IF 12.020)
3. Kim HS, Yoon JS, Jeon Y, Park EJ, Lee JK, Chen S, Lee H, Park JY, Go H, and Lee CW. Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma. Cell Death and Differentiation, 2022, 29(3):600-613. (IF 12.067)
4. Lee JK, Koo SY, Nam HM, Lee JB, Ko J, Kim KM, Park EJ, Kim TJ, Lee H, Go H and Lee CW. Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells. Cellular and Molecular Immunology, 2021, 18(6):1395-1411. (IF 22.096)
5. Ha GH, Ji JH, Chea S, Park J, Kim S, Lee JK, Kim Y, Min S, Park JM, Kang TH, Lee H, Cho H, Lee CW. Pellino1 regulates reversible ATM activation vio NBS1 ubiqutination at DNA double strand breaks. Nature Communications, 2019, 10(1):1577:1-14 (IF 17.694)
6. Kim SH, Jeon Y, Kim HS, Lee JK, Lim HJ, Kang D, Cho H, Park CK, Lee H, Lee CW. Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology, 2016, 63(1):247-259. (IF 17.298)
7. Park HY, Go H, Song HR, Kim S, Ha GH, Jeon YK, Kim JE, Lee H, Cho H, Kang HC, Chung HY, Kim CW, Chung DH, and Lee CW. Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. Journal of Clinical Investigation, 2014, 124(11):4976-4988. (IF 19.456)
8. Shin HJ, Baek KH, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, McKeon F, and Lee CW. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 2003, 4(6):483-497. (IF 38.585)