SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
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Jeong-Yun Choi
Jeong-Yun Choi PhD
| Graduate Program | Cancer Biology & Data Science and Personalized Medicine |
| Research Area | Molecular Toxicology and Pharmacology |
| Laboratory | Molecular Toxicology and Pharmacology Lab Laboratory |
| choijy@skku.edu | |
| Tel | +82-31-299-6193 |
Education & Careers
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2011~Present Professor, Sungkyunkwan University School of Medicine, Suwon, Korea
2006~2011 Assistant Professor, School of Medicine, Ewha Womans University, Seoul, Korea
2002~2006 Post-doc, Vanderbilt University School of Medicine, TN, USA
1996~1999 PhD, College of Medicine, Seoul National University, Seoul, Korea
1994~1996 MS, College of Medicine, Seoul National University, Seoul, Korea
1988~1994 BS, MD, College of Medicine, Seoul National University, Seoul, Korea
Research Interest
1. Translesion DNA synthesis (TLS) across carcinogen-modified DNA lesions by DNA polymerases.
2. The role of human DNA polymerases & their genomic variations in mutagenesis & carcinogenesis.
3. Identification and development of anticancer therapy resistance gene markers, genotoxicity indexes and in vitro screening systems.
4. Interrelations of three R (DNA replication, repair, recombination) processes against DNA damage and its disease association.
2. The role of human DNA polymerases & their genomic variations in mutagenesis & carcinogenesis.
3. Identification and development of anticancer therapy resistance gene markers, genotoxicity indexes and in vitro screening systems.
4. Interrelations of three R (DNA replication, repair, recombination) processes against DNA damage and its disease association.
Representative Research Achievements
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1. Yeom M, Hong JK, Kim JK, Guengerich FP, Choi JY. Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H2O2 Sensitivity in POLI-Deficient Cells. Chem Res Toxicol (2020) 33(8):2120-2129
2. Kim JK, Yeom M, Hong JK, Song I, Lee YS, Guengerich FP, Choi JY. Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase &61472&61547. Chem Res Toxicol (2016) 29(10):1741-1754
3. Choi JY, Patra A, Yeom M, Lee YS, Zhang Q, Egli M, Guengerich FP. Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota. J Biol Chem (2016) 291(40):21063-21073
4. Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chem Res Toxicol (2016) 29(3):367-379
5. Kim J, Song I, Jo A, Shin JH, Cho H, Eoff RL, Guengerich FP, Choi JY. Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis. Chem Res Toxicol (2014) 27(10):1837-52
6. Song I, Kim EJ, Kim IH, Park EM, Lee KE, Shin JH, Guengerich FP, Choi JY. Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts. Chem Res Toxicol (2014) 27(5):919-30
7. Lim S, Song I, Guengerich FP, and Choi JY. Effects of N2-Alkylguanine, O6-Alkylguanine, and Abasic Lesions on DNA Binding and Bypass Synthesis by the Euryarchaeal B-family DNA Polymerase Vent (exo-). Chem Res Toxicol (2012) 25(8):1699-1707
8. Choi JY, Eoff RL, Guengerich FP. Bypass DNA Polymerases. In: Penning TM (ed) Chemical Carcinogenesis. Humana Press, New York. (2011) 345-373
9. Choi JY, Lim S, Kim EJ, Jo A, Guengerich FP. Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. J Mol Biol (2010) 404(1):34-44
10. Choi JY and Guengerich FP. Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1. J Biol Chem (2008) 283(35):23645-55