SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Jong-Sun Kang
Jong-Sun Kang PhD
| Graduate Program | Development and Regenerative Medicine |
| Research Area | Stem cell function control mechanism, muscle/cardiovascular disease mechanism and treatment development |
| Laboratory | Laboratory of Stem Cell Differentiation Laboratory |
| kangj01@skku.edu | |
| Tel | +82-31-299-6135 |
Education & Careers
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2007-present Sungkyunkwan University School of Medicine, Associate Professor, Professor
1999-2007 Mount Sinai School of Medicine of NYU, USA, Instructor, Assistant Professor
1994-1999 Mount Sinai School of Medicine of NYU, USA, Research Associate
1990-1994 Albert-Ludwigs University Freiburg, Germany, Ph.D.
1985-1990 Albert-Ludwigs University Freiburg, Germany, Diplom.
1981-1985 Pusan National University, Biology, BS
Research Interest
The goal of the research in my laboratory is to understand the molecular regulatory pathways that control proliferation and differentiation of stem cells during regeneration and underlying molecular mechanisms in stem cell dysfunction related to aging or degenerative diseases. Our current research is focused on the elucidation of regulatory mechanisms and in vivo function of key stem niche signals (Sonic hedgehog and Wnt), cell adhesion molecules and protein arginine methyltransferases by utilizing knockout mice, disease animal models and stem cells as model systems. The long-term goal of this research is to identify molecular targets for the development of therapeutic tools to intervene the aging-related muscle atrophy, cardiovascular diseases or degenerative diseases.
Representative Research Achievements
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1. Wei S, Zhang Y, Kang BE, Park W, Guo H, Nam S, Kang JS, Jeong JH, Jo Y, Ryu D, Jiang Y, Ha KT., 2024: CDKN2 expression is a potential biomarker for T cell exhaustion in hepatocellular carcinoma.. BMB Rep., 57(6), 287 - 292
2. Y Zhang, S Wei, H Zhang, Y Jo, Jong-Sun Kang, K-T Ha, J Joo, H J Lee, D Ryu., 2024: Gut microbiota-generated metabolites: missing puzzles to hosts health, diseases, and aging. BMB Rep ., 57(5), 207 - 215
3. Byeong-Yun Ahn , Yideul Jeong , Sunghee Kim , Yan Zhang , Su Woo Kim , Young-Eun Leem , Jong-Sun Kang, 2023: Cdon suppresses vascular smooth muscle calcification via repression of the Wnt/Runx2 Axis. Exp Mol Med. 55,120 - 131
4. Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection J-H Pyun, B-Y Ahn , T A Vuong , S W Kim, Y Jo , J. Jeon , S H Baek , J. Kim , S Park , G-U Bae , J-H Choi , J-R Kim , D. Ryu , S-J Lee , J-S Kang. Exp Mol Med.
10(53),1569 - 1579 (2021)
5. JH BAE, HJ JEONG, HB KIM, YE LEEM, D RYU, SC PARK, YL LEE, SC CHO, JS KANG, 2020: ZNF746/PARIS overexpression induces cellular senescence through FoxO1/p21 axis activation in myoblasts. Cell Death & Disease,11(5), 359
6. JH BAE, M HONG, HJ JEONG, HB KIM, SJ LEE, D RYU, GU BAE, SC CHO, YS LEE, RS KRAUSS, JS KANG, 2020: Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. Journal of Cachexia, Sarcopenia and Muscle, 11(4),1104-
1120.
7. HB KIM, SC CHO, HJ JEONG, HY LEE, MH JEONG, JH PYUN, D RYU, MS KIM, YS LEE, MS KIM, SC PARK, YL LEE, JS KANG, 2020: Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway. Journal of Cachexia, Sarcopenia and Muscle,
11(4),1070-1088.
8. MH Jeong,HJ Jeong,, BY Ahn, JH Pyun, I Kwon, H Cho. JS Kang, 2019: PRMT1 suppresses ATF4-mediated endoplasmic reticulum response in cardiomyocytes. Cell Death & Disease, Dec. 2: 10(12):903
9. HR KO, I HWANG, EJ JIN, T YUN, D RYU, JS KANG, KW PARK, JH SHIN, SW CHO, KH LEE, K YE, JY AHN, 2019: Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control.Proc Natl Acad Sci U S A, 116(49):24852-24860
10. Jeong HJ, Lee SJ, Lee HJ, Kim HB, Vuong TA, Cho H, Bae GU, Kang JS, 2019: Prmt7 promotes myoblast differentiation via methylation. Cell Death & Differentiation, 27, 573-586
11. Vuong TA, HJ Jeong, HJ Lee, BG Kim, YE Leem, H Cho, JS Kang. 2019. PRMT7 methlates and suppresses GLl2 binding to SUFU thereby promoting its activation. Cell Death & Differentiation..27, 15&821128
12. Lee SY,Vuong TA,, Wen X,, Jeong HJ, So HK,, Kwon I, Kang JS,*.*, Cho H*.*, 2019: Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells.. Exp Mol Med., 51(10), (*.* equal contribution)
13. Vuong TA, Lee SJ, Leem YE, Lee JR, Bae GU, Kang JS, SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth. Cell Signal. 2019 Jan 955:100-108
14. S Choi, HJ Jeong, H Kim, D Choi, SC Cho, SH Koo, JS Kang, 2019. Skeletal muscle-specific PRMT1 deletion causes muscle atrophy via deregulation of PRMT6/FOXO3 axis. Autophagy, 15(6):1069-1081.
15. JH Pyun, HJ Kim, MH Jeong, BY Ahn, TA Voung, DI Lee, S Choi, SH Koo, H Cho, JS Kang, 2018. Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation. Nature Communications, 9(1):5107
16. J Park, H Lee, N Han, S Kwak, HT Lee, JH Kim, K Kang, BH Yeon, JH Yang, HJ Jeong, JS Kang, SY Kim, JW Han, HD Youn, EJ Cho, 2018. Long noncoding RNA ChRo1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin
reorganization. Nucleic Acid Research. 46(22):11759-11775.
17. myong-ho jeong, hyun-ji kim, jung-hoon pyun, kyu-sil choi, dong i lee, soroosh solhjoo, brian orourke, gordon f.tomaselli, dong seop jeong, hana cho, jong-sun kang. 2017 Cdon deficiency causes cardiac remodeling through hyperactivation of WNT/β-catenin signaling. Proc Natl Acad Sci U S A
18. JKim HJ, Jeong MH, Kim KR, Jung CY, Lee SY, Kim H, Koh J, Vuong TA, Jung S, Yang H, Park SK, Choi D, Kim SH, Kang K, Sohn JW, Park JM, Jeon D, Koo SH, Ho WK, Kang JS*, Kim ST,* Cho H.*(cover story* faculty of 1000 biology selected.co-corresponding)Protein arginine methylation facilitates KCNQ channel-PIP2 interaction leading to seizure suppression. eLIfe. 2016, jul.
19. jeong HJ, Lee HJ, Vuong TA, Choi KS, Choi D, Koo SH, Cho SC, Cho H, Kang JS. Prmt7 Deficiency Causes Reduced Skeletal Muscle Oxidative Metabolism and Age-Related Obesity. Diabetes. 2016 Jul65(7):1868-82
20. Yoo M+, Kim BG+, Lee SJ, Jeong HJ, Park JW, Seo DW, Kim YK, Lee HY, Han JW, Kang JS*, Bae GU*Syntaxin 4 regulates the surface localization of a promyogenic receptor Cdo thereby promoting myogenicdifferentiation. Skeletal Muscle. 2015 Sep 75:28.(*Co-correspondence)
21. Hye-Jin Lee, Shin-Bum Jo, Anthony I. Romer, Hyo-Jeong Lim, Min-Jung Kim,Seung-Hoi Koo, Robert S. Krauss, and Jong-Sun Kang.Overweight in Mice and Enhanced Adipogenesis In Vitro Are Associated With Lack of the Hedgehog Coreceptor Boc. Diabetes 201564:2092&82112103
22. Jeong MH, Ho, SM, Vuong TA, Jo SB, Liu G, Aaronson SA, Leem YE, Kang JS., 2014: Cdo suppresses canonical Wnt signaling via interaction with LRP6 thereby promoting neuronal differentiation. Nature Communications, 5, 5455
23. De D, Jeong MH, Leem YE, Svergun DI, Wemmer DE, Kang JS*, Kim KK*, Kim SH*.(*Co-correspondence) 2014 Inhibition of master transcription factors in pluripotent cells induces early stage differentiation. Proc Natl Acad Sci U S A 111 (5) 1778-1783.
24. Tran P, Ho SM, Kim BG, Vuong TA, Leem YE, Bae GU, Kang JS., 2012: TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway. J Biol Chem., 287(15), 11602 - 11615.
25. GU Bae, S Domene, E Roessler, K Schachter, JS Kang*, M Muenke*, RS Krauss.(* Co-correspondence ), 2011: Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.. Am. J. Human Genetics, 12 (89(2)),
26. Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, Mcmahon AP., 2011: Overlapping roles and collective. Dev. Cell., 20(6), 775-787
27. Han JW, Lee HJ, Bae GU, Kang JS, 2011: Promyogenic function of Integrin/FAK signaling is mediated by Cdo, Cdc42 and MyoD.. Cell Signal., 23(7), 1162-1169
28. GU Bae, BG Kim, HJ Lee, JE Oh, SJ Lee, W Zhang, RS Krauss, JS Kang, 2009. Cdo binds Abl to promote p38MAPK activity and myogenic differentiation, Mol. Cell. Biol, 29(15):4130-4143.
29. JE Oh, GU Bae, YJ Yang, MJ Yi, HJ Lee, BG Kim, RS Krauss, JS Kang, 2009. Cdo promotes neuronal differentiation via activation of the p38MAPK pathway, FASEB J., 23 (7): 2088-2099
30. JS Kang*, GU Bae, MJ Yi, YJ Yang, JE Oh, G Takaesu, YT Zhou, BC Low, RS Krauss*, 2008. A Cdo-Bnip2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation, J. Cell Biol, 182: 497-507. (*Co- corresponding)