SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
List
Professor
Professor
List
Tae Jin Kim
Tae Jin Kim PhD
| Graduate Program | Infection and Immunity |
| Research Area | Antibody-secreting Cell Regulation, T/B Cell Interaction, Tumor Immunity, Autoimmune Disease |
| Laboratory | Laboratory of Immunopathology Laboratory |
| tjkim@skku.edu | |
| Tel | +82-31-299-6262 |
Education & Careers
-
1982 - 1988 Seoul National University College of Medicine, B.S.
1988 - 1992 Specialist in Pathology, Seoul National University Hospital
1989 - 1994 Seoul National University College of Medicine, Ph.D.
1993 - 1997 Harvard Medical School & MGH cancer center, Research Fellow
1997 - Present Assistant Professor, Associate Professor, Professor, Sungkyunkwan University School of Medicine
Research Interest
The immune response monitors and destroys infections and tumors, but at the same time maintains the bodys homeostasis.
When this homeostasis is disrupted, autoimmune diseases and other seemingly immune-related diseases (diabetes mellitus, pulmonary fibrosis, etc.) also occur. B cells are the cells that our laboratory studies centrally, and we conduct research on their regulation and autoantibody secretion regulation. It is generally known that T cells help B cells, but in reality, the complex interaction between these two cells can lead to T cell hyperactivity and T cell-mediated autoimmune diseases. Among B cells, we discovered B-1 helper T cells that help the natural antibody-secreting cell group called B-1 cells, and we are studying their clinical significance and mechanism. These studies mainly use mouse models and at the same time, in collaboration with the clinical field, are conducting studies on the regulation of lymphocytes infiltrating tumors and B cells in autoimmune diseases.
When this homeostasis is disrupted, autoimmune diseases and other seemingly immune-related diseases (diabetes mellitus, pulmonary fibrosis, etc.) also occur. B cells are the cells that our laboratory studies centrally, and we conduct research on their regulation and autoantibody secretion regulation. It is generally known that T cells help B cells, but in reality, the complex interaction between these two cells can lead to T cell hyperactivity and T cell-mediated autoimmune diseases. Among B cells, we discovered B-1 helper T cells that help the natural antibody-secreting cell group called B-1 cells, and we are studying their clinical significance and mechanism. These studies mainly use mouse models and at the same time, in collaboration with the clinical field, are conducting studies on the regulation of lymphocytes infiltrating tumors and B cells in autoimmune diseases.
Representative Research Achievements
-
1. Lee, S., Ko, Y., Lee, H. W., Oh, W. J., Hong, H. G., Ariyaratne, D., ... & Kim, T. J. (2024). Two distinct subpopulations of marginal zone B cells exhibit differential antibody-producing capacities and radioresistance. Cellular & Molecular Immunology, 21(4), 393-408.
2. Lee, S., & Kim, T. J. (2024). ROS-induced metabolic reprogramming to one-carbon metabolism and S-adenosylmethionine-mediated epigenetic modification in IL-10-producing B cells for the resolution of pneumonia. Cellular & Molecular Immunology, 21(2), 203-204.
3. Lee, K. W., Choi, M. R., Kwon, O. K., Chung, Y. S., Lee, S., Shim, J., Choi, K., Sonn, C. H., Cho, B., Kim, S. J., Kim, T. J., Park, J. B. (2023). 108.4: Deletion of additional iGb3s in GGTA1/B4GalNT2/CMAH knock-out pig reduces lymphocyte infiltration and tissue factor deposition in pig-to-cynomolgus arteriovenous fistula model. Transplantation, 107(10S2), 14.
4. Kim, T. J., Im, S. J., Lee, S., Ko, Y., Lee, H. W., Oh, W. J., & Hong, H. G. (2023). Two Distinct Subpopulations of Marginal Zone B Cells Exhibit Differential Antibody-Producing Capacity and Radioresistance.
5. Lee, S., Yang, J. I., Lee, J. H., Lee, H. W., & Kim, T. J. (2022). Low-Level Expression of CD138 Marks Naturally Arising Anergic B Cells. Immune Network, 22(6).
6. Diep, Y. N., Kim, T. J., Cho, H., & Lee, L. P. (2022). Nanomedicine for advanced cancer immunotherapy. Journal of Controlled Release, 351, 1017-1037.
7. Lee, H. W., C. Park, J. G. Joung, M. Kang, Y. S. Chung, W. J. Oh, S. Y. Yeom, W. Y. Park, T. J. Kim*, and S. I. Seo*. (2021). Renal Cell Carcinoma-Infiltrating CD3low Vγ9Vδ1 T Cells Represent Potentially Novel Anti-Tumor Immune Players. Current Issues in Molecular Biology, 43(1), 226-239.
8. Lee, S., Ko, Y., & Kim, T. J. (2020). Homeostasis and regulation of autoreactive B cells. Cellular & molecular immunology, 17(6), 561-569.
9. Liu, W., Tolar, P., Song, W., & Kim, T. J. (2020). Bcr signaling and b cell activation. Frontiers in immunology, 11, 45.
10. Lee, H. W., Chung, Y. S., & Kim, T. J. (2020). Heterogeneity of human γδ T cells and their role in cancer immunity. Immune Network, 20(1).
11. Zhao X, Xie H, Zhao M, Ahsan A, Li X, Wang F, Yi J, Zhiyong Yang, Wu C, Raman I, Li Q-Z*, Kim TJ*, Liu W*. (2019). Fc receptor&8211like 1 intrinsically recruits c-Abl to enhance B cell activation and function. Science advances, 5(7), eaaw0315.
12. Lee, M., Park, C., Woo, J., Kim, J., Kho, I., Nam, D. H., ... & Kim, T. J. (2019). Preferential infiltration of unique Vγ9Jγ2-Vδ2 T cells into glioblastoma multiforme. Frontiers in Immunology, 10, 555.
13. Park, C., & Kim, T. J. (2018). Expansion and sub-classification of T cell-dependent antibody responses to encompass the role of innate-like T cells in antibody responses. Immune Network, 18(5).
14. Moon, H., Park, C., Lee, J. G., Shin, S. H., Lee, J. H., Kho, I., ... & Kim, T. J. (2015). Early development in the peritoneal cavity of CD49dhigh Th1 memory phenotype CD4+ T cells with enhanced B cell helper activity. The Journal of Immunology, 195(2), 564-575.