SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
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Jee-Heon Jeong
Jee-Heon Jeong PhD
| Graduate Program | Data Science & Precision Medicine |
| Research Area | Cell Therapy, Drug Delivery, 3D Cell Culture System |
| Laboratory | Laboratory of Drug Delivery and Cell Therapy Laboratory |
| jeeheon@skku.edu | |
| Tel | +82-31-299-6165 |
Education & Careers
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2002-2004 B.S. College of Pharmacy, Chungnam National University
2006-2013 Ph. D. College of Pharmacy, Seoul National University
2007-2008 Visiting Researcher, School of Medicine, University of Minnesota
2013-2019 Assistant Professor, College of Pharmacy, Yeungnam University
2019-2022 Associate Professor, College of Pharmacy, Yeungnam University
2022-Present Associate Professor, Department of Precision Medicine, School of Medicine, Sungkyunkwan University
Research Interest
Our research interest consists of using drug delivery technology to improve the therapeutic effect of cytomedicine following transplantation.
Our research topics can be summarized as follow:
Research on improving the therapeutic effect of cytomedicine using 3D cell culture system and drug delivery system
Research on developing cell surface engineering technology to improve the therapeutic effect of cytomedicine
Our research topics can be summarized as follow:
Research on improving the therapeutic effect of cytomedicine using 3D cell culture system and drug delivery system
Research on developing cell surface engineering technology to improve the therapeutic effect of cytomedicine
Representative Research Achievements
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Selected Publications (2018-2023)
1. Duc-Vinh Pham, Prakash Shrestha, Thi-Kem Nguyen, Junhyeung Park, Mahesh Pandit, Jae-Hoon Chang, Soo Young Kim, Dong-Young Choi, Sung Soo Han, Inho Choi, Gyu Hwan Park, Jee-Heon Jeong**, Pil-Hoon Park**, “Modulation of NLRP3 inflammasomes activation contributes to improved survival and function of mesenchymal stromal cell spheroids”, 31(3), Molecular Therapy (IF=11.454), Mar, 2023, 890-908
2. Ramesh Duwa*, Ram Hari Pokhrel*, Asmita Banstola, Mahesh Pandit, Prakash Shrestha, Jee-Heon Jeong**, Jae-Hoon Chang**, SimmyungYook**, T-cell engaging poly(lactic-co-glycolic acid) nanoparticles as a modular platform to induce a potent cytotoxic immunogenic response against PD-L1 overexpressing cancer, 291, Biomaterials (IF=15.304), Dec, 2022, 1221911
3. Phuong Le Tran*, Ju-Hyun Kim*, Young-Heun Jung, Dong-Cheol Lee, Jeong Uk Choi, Duy Ngoc Le, Joo-Won Nam, Manju Shrestha, Ju-Yeon Kim, Tung Thanh Pham**, Jee&8211Heon Jeong**, “Prolongation of graft survival via layer-by-layer assembly of collagen and immunosuppressive particles on pancreatic islets”, 290, Biomaterials (IF= 15.304), Nov, 2022, 121804
4. Asmita Banstola, Mahesh Pandit, Ramesh Duwa, Jae-Hoon Chang, Jee-Heon Jeong**, Simmyung Yook**. “Reactive oxygen species-responsive dual-targeted nanosystem promoted immunogenic cell death against breast cancer”, Bioengineering & Translational Medicine (IF=10.684), in press
5. Tiep Tien Nguyen, Duc-Vinh Pham, Junhyeung Park, Cao Dai Phung, Mahesh Raj Nepal, Mahesh Pandit, Manju Shrestha, Youlim Son, Mili Joshi, Tae Cheon Jeong, Pil-Hoon Park, Dong-Young Choi, Jae-Hoon Chang, Ju-Hyun Kim, Jae-Ryong Kim, Il-Kug Kim, Chul Soon Yong, Jong Oh Kim, Jong-Hyuk Sung, Hu-Lin Jiang, Hyung-Sik Kim, Simmyung Yook**, Jee-Heon Jeong**, “Engineering of hybrid spheroids of mesenchymal stem cells and drug depots for immunomodulating effect in islet xenotransplantation”, 8(34), Science Advances (IF=14.957), Aug, 2022
6. Shobha Regmi*, Pawan Kumar Raut*, Shiva Pathak, Prakash Shrestha, Pil-Hoon Park**, Jee-Heon Jeong**, “Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction”, 17(10), Autophagy (IF=13.391), Oct 2021
7. Asmita Banstola, Kishwor Poudel, Jong Oh Kim, Jee-Heon Jeong**, Simmyung Yook**. “Recent Progress in Stimuli-Responseive Nanosystems for Inducing Immunogenic Cell Death”. Journal of Controlled Release (IF=11.467), Sep 2021, 337, 505-520.
8. Tiep Tien Nguyen*, Cao Dai Phung, Jong Oh Kim, Chul Soon Yong, Jae-Ryong Kim, Simmyung Yook**, Jee-Heon Jeong**, “The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on xenogeneic islet survival”, Journal of Controlled Release (IF=11.467), 336, Aug 2021, 274-284
9. Asmita Banstola, Kishwor Poudel, Shiva Pathak, Prakash Shrestha, Jong Oh Kim, Jee-Heon Jeong**, Simmyung Yook**. “Hypoxia-Mediated ROS Amplification Triggers Mitochondria-Mediated Apoptotic Cell Death via PD-L1/ROS-Responsive, Dual-Targeted, Drug-Laden Thioketal Nanoparticles”. ACS Applied materials & Interfaces (IF=10.383), May 2021, 13(19), 22955-22969.
10. Fakhrossadat Emami, Shiva Pathak, Tiep Tien Nguyen, Prakash Shrestha, Srijan Maharjan, Jong Oh Kim, Jee-Heon Jeong**. Simmyung Yook**. “Photoimmunotherapy with cetuximab-conjugated gold nanorods reduces drug resistance in triple negative breast cancer spheroids with enhanced infiltration of tumor-associated macrophages”, Journal of Controlled Release (IF=11.467), Jan 2021, 329, 645-664.
11. Shobha Regmi*, Yoogin Seo*, Ji-Su Ahn*, Shiva Pathak, Suman Acharya, Tiep Tien Nguyen, Simmyung Yook, Jong-Hyuk Sung, Jun-Beom Park, Jong Oh Kim, Chul Soon Young, Hyung-Sik Kim**, Jee-Heon Jeong**, “Heterospheroid formation improves therapeutic efficacy of mesenchymal stem cells in murine colitis through immunomodulation and epithelial regeneration, Biomaterials (IF= 15.304), 271, Apr 2021, 120752
12. Tung Thanh Pham, Phuong Le Tran, Cao Dai Phung, Hanh Thuy Nguyen, Canh Hung Nguyen, Chul Soon Yong, Jong Oh Kim, Simmyung Yook**, Jee-Heon Jeong**, “Surface triggered in situ gelation for tunable conformal hydrogel coating of therapeutic cells and biomedical devices”, Advanced Functional Materials (IF=19.924), 31, May 2021, 2010169
13. Shiva Pathak*, Suman Acharya*, Shobha Regmi, Prakash Shrestha, Zhiwei You, Young Kyung Bae, Min Hui Park, Simmyung Yook, Jae-Ryong Kim, So Young Park, Daewon Jeong, Chul Soon Yong, Jong Oh Kim, Jae Hoon Chang**, Jee-Heon Jeong**, “Particulate-Based Single-Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation”, Advanced Healthcare Materials (IF=11.092), 10(2), Jan 2021, 2001157
14. Asmita Banstola, Jee-Heon Jeong**, Simmyung Yook**. “Immunoadjuvants for cancer immunotherapy: A review of recent developments”. Acta Biomaterialia (IF=10.633), Sep 2020, 114, 16-30.
15. Tiep Tien Nguyen, Fakhrossadat Emami, Simmyung Yook**, Hanh Thuy Nguye, Tung Thanh Pham, Shiva Pathak, Shobha Regmi, Jong Oh Kim, Chul Soon Yong, Jae-Ryong Kim, Jee-Heon Jeong**. “Local release of NECA (5-(N-ethylcarboxamido)adenosine) from implantable polymeric sheets for enhanced islet revascularization in extrahepatic transplantation site”. Journal of Controlled Release (IF=11.467), May 2020, 10(321), 509-518.
16. Shobha Regmi*, Shiva Pathak*, Mahesh Raj Nepal, Prakash Shrestha, Junhyeung Park, Jong Oh Kim, Chul Soon Yong, Dong-Yong Choi, Jae-Hoon Chang, Tae Cheon Jeong, Gorka Orive, Simmyung Yook**, Jee-Heon Jeong**. “Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1/Th17 differentiation”. Journal of Controlled Release (IF=11.467), , Dec 2019, 316, 138-149.
17. Tiep Tien Nguyen*, Tung Thanh Pham*, Hanh Thuy Nguyen, Mahesh Raj Nepal, Cao Dai Phung, Zhiwei You, Nikita Katila, Nirmala Tilija Pun, Dong-Young Choi, Pil-Hoon Park, Chul Soon Yong, Jong Oh Kim, Simmyung Yook**, Jee-Heon Jeong**, “Engineering cell-pharicle hybrids” of pancreatic islets and bioadhesive FK506-loaded polymeric microspheres for local immunomodulation in xenogeneic islet transplantation”, Biomaterials (IF=15.304), 221, Nov 2019, 119415
18. Shiva Pathak*, Tung Thanh Pham*, Jee-Heon Jeong**, Youngro Byun**. "Immunoisolation of pancreatic islets via thin-layer surface modification". Journal of Controlled Release (IF=11.467), Jul 2019, 305, 176-193.
19. Shiva Pathak*, Shobha Regmi, Prakash Shrestha, Inho Choi, Kyoung-Oh Doh, Jee-Heon Jeong**, “Mesenchymal stem cell capping on ECM-anchored caspase inhibitor-loaded PLGA microspheres for intraperitoneal injection in DSS-induced murine colitis”, Small (IF=15.153), 15(23), June 2019, 1901269 (Cover Story)
20. Shiva Pathak, Shobha Regmi, Tiep Tien Nguyen, Biki Gupta, Milan Gautam, Chul Soon Yong, Yong Pal Kim, Youlim Son, Jae-Ryong Kim, Min Hui Park, Young Kyung Bae, So Young Park, Daewon Jeong, Simmyung Yook**, Jee-Heon Jeong**. “Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse model of diabetes”. Acta Biomaterialia (IF=10.633), Jul 2018, 75, 287-299.
21. Tung Thanh Pham, Tiep Tien Nguyen, Shiva Pathak, Shobha Regmi, Hanh Thuy Nguyen, Tuan Hiep Tran, Chul Soon Yong, Jong Oh Kim, Pil-Hoon Park, Young Kyung Bae, Jeong Uk Choi, Yongro Byun, Cheol-Hee Ahn, Simmyung Yook**, Jee-Heon Jeong**. “Tissue adhesive FK506-loaded polymeric nanoparticles for multi-layered anno-shielding of pancreatic islets to enhance xenograft survival in diabetic mouse model”. Biomaterials (IF=15.304), Feb 2018, 154, 182-196.