SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
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Professor
Professor
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Kyeung Min Joo
Kyeung Min Joo PhD
| Graduate Program | Deveopment and Regenerative medicine |
| Research Area | Stem cell treatment for neurodegenerative disease and cancer |
| Laboratory | Cancer metastasis & Stem cell Laboratory Laboratory |
| kmjoo@skku.edu | |
| Tel | +82-31-299-6073 |
Education & Careers
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2018-Present. Medinno Inc. (Founder & CEO)
2018-Present. Professor (Full), Department of Anatomy and Cell Biology, Sungkyunkwan University School of Medicine
2014-2017 Visiting Research Scholar, Department of Radiation Oncology, Duke University Medical Center
2012-2018 Assistant Professor, Associate Professor, Department of Anatomy and Cell Biology, Sungkyunkwan University School of Medicine
2009-2012 Assistant professor, Department of Anatomy, Seoul National University College of Medicine
2006-2009 Postdoctoral fellow, Department of Neurosurgery, Samsung Medical Center
2002-2006 Ph.D. (Medicine, Neuroscience), Seoul National University College of Medicine
1996-2002 B.S. (M.D.), Seoul National University College of Medicine
Research Interest
1. Mesenchymal Stem cell Engineering by cell enucleation
2. Stable Cell line production for immortalization of MSCs
3. Brain Metastasis Therapy with therapeutic gene delivery
4. Ischemic Stroke Therapy with therapeutic gene delivery
5. Multiple Sclerosis Therapy with therapeutic gene delivery
2. Stable Cell line production for immortalization of MSCs
3. Brain Metastasis Therapy with therapeutic gene delivery
4. Ischemic Stroke Therapy with therapeutic gene delivery
5. Multiple Sclerosis Therapy with therapeutic gene delivery
Representative Research Achievements
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- Google Scholar: https://scholar.google.com/citations?user=wFzz-lEAAAAJ&hl=en
- Research Gate: https://www.researchgate.net/profile/Kyeung_Min_Joo
1. Bang, Y., Hwang, S., Kim, Y. E., Sung, D. K., Yang, M., Ahn, S. Y., ... & Chang, Y. S. (2024). Therapeutic efficacy of thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles on Escherichia coli-induced acute lung injury in mice. Respiratory Research, 25(1), 303.
2. Lee, M., Park, S. H., Joo, K. M., Kwon, J. Y., Lee, K. H., & Kang, K. (2024). Drosophila HCN mediates gustatory homeostasis by preserving sensillar transepithelial potential in sweet environments. bioRxiv, 2024-02.
3. Ha, G. H., Yeon, J. Y., Kim, K. H., Lee, D. M., Chae, H. Y., Nam, H., ... & Joo, K. M. (2024). Thrombin Priming Promotes the Neuroprotective Effects of Human Whartons Jelly-Derived Mesenchymal Stem Cells Via the HGF/AKT/STAT3 Signaling Pathway. Stem Cells and Development, 33(3-4), 89-103.
4. Lee, D. M., Lee, S. H., Hong, T. H., Lee, J. C., Nam, H., & Joo, K. M. (2023). Effects of ethanol washing and storage duration on primary culture of stem cells from human exfoliated deciduous teeth. Journal of Oral Biology and Craniofacial Research, 13(5), 598-603.
5. Lee, M., Kim, S. Y., Park, T., Joo, K. M., Kwon, J. Y., Kim, K., & Kang, K. (2023). Unilateral ephaptic program underlying sweetness dominance. bioRxiv, 2023-08.
6. Jeon, H. M., Oh, Y. T., Shin, Y. J., Chang, N., Kim, D., Woo, D., ... & Lee, J. (2023). Dopamine receptor D2 regulates glioblastoma survival and death through MET and death receptor 4/5. Neoplasia, 39, 100894.
7. Lee, S., Nam, H., Joo, K. M., & Lee, S. H. (2022). Advances in neural stem cell therapy for spinal cord injury: safety, efficacy, and future perspectives. Neurospine, 19(4), 946.
8. Ha, G. H., Kim, E. J., Park, J. S., Kim, J. E., Nam, H., Yeon, J. Y., ... & Joo, K. M. (2022). JAK2/STAT3 pathway mediates neuroprotective and pro-angiogenic treatment effects of adult human neural stem cells in middle cerebral artery occlusion stroke animal models. Aging (Albany NY), 14(22), 8944.
9. Kim, W., Kim, J., Lee, S. Y., Kim, H. M., Jung, H., Joo, K. M., & Nam, D. H. (2022). Functional validation of the simplified in vitro 3D Co-culture based BBB model. Biochemical and Biophysical Research Communications, 625, 128-133.
10. Kim, C. K., Park, J. S., Kim, E., Oh, M. K., Lee, Y. T., Yoon, K. J., ... & Park, Y. S. (2022). The effects of early exercise in traumatic brain-injured rats with changes in motor ability, brain tissue, and biomarkers. BMB reports, 55(10), 512.
11. Kim, W., Kim, J., Lee, S. Y., Kim, H. M., Joo, K. M., & Nam, D. H. (2022). Simplified in vitro 3D co-culture-based blood-brain barrier model using transwell. Biochemical and biophysical research communications, 620, 63-68.
12. Joo, Kyeung Min, and Hyun Nam. "Method for isolating and culturing neural stem cells with high efficiency." U.S. Patent Application No. 16/980,889.
13. Kim, C. K., Hwang, J. Y., Hong, T. H., Lee, D. M., Lee, K., Nam, H., & Joo, K. M. (2022). Combination stem cell therapy using dental pulp stem cells and human umbilical vein endothelial cells for critical hindlimb ischemia. BMB reports, 55(7), 336.
14. Jung, S. Y., Kim, Y. E., Park, W. S., Ahn, S. Y., Sung, D. K., Sung, S. I., ... & Chang, Y. S. (2022). Thrombin preconditioning improves the therapeutic efficacy of mesenchymal stem cells in severe intraventricular hemorrhage induced neonatal rats. International Journal of Molecular Sciences, 23(8), 4447.
15. Kim, C. K., Won, J. S., An, J. Y., Lee, H. J., Nam, A. J., Nam, H., ... & Joo, K. M. (2022). Significant Therapeutic Effects of Adult Human Neural Stem Cells for Spinal Cord Injury Are Mediated by Monocyte Chemoattractant Protein-1 (MCP-1). International Journal of Molecular Sciences, 23(8), 4267.
16. Hyun, N., In&8209Hee, L., Sa, J. K., Kim, S. S., Hee&8209Jang, P., Lee, K. H., ... & Min, J. K. (2022). Correction to: Effects of Long-Term In Vitro Expansion on Genetic Stability and Tumor Formation Capacity of Stem Cells. Stem Cell Reviews and Reports, 18(1), 258-258.
17. Nam, H., Lee, I. H., Sa, J. K., Kim, S. S., Pyeon, H. J., Lee, K. H., ... & Joo, K. M. (2022). Effects of Long-Term In Vitro Expansion on Genetic Stability and Tumor Formation Capacity of Stem Cells. Stem Cell Reviews and Reports, 1-17.
18. Won, J. S., Yeon, J. Y., Pyeon, H. J., Noh, Y. J., Hwang, J. Y., Kim, C. K., ... & Joo, K. M. (2021). Optimal preclinical conditions for using adult human multipotent neural cells in the treatment of spinal cord injury. International journal of molecular sciences, 22(5), 2579.
19. Joo, Kyeung Min, and Hyun Nam. "Angiogenesis-inducing method using neural stem cell." U.S. Patent Application No. 16/980,886.
20. Kim, S. S., Pyeon, H. J., Bae, Y. K., Nam, H., Kim, C. K., Lee, S. H., & Joo, K. M. (2021). Adult Human Multipotent Neural Cells Could Be Distinguished from Other Cell Types by Proangiogenic Paracrine Effects via MCP&82081 and GRO. Stem Cells International, 2021(1), 6737288.
21. Lee, H. W., Chung, W., Lee, H. O., Jeong, D. E., Jo, A., Lim, J. E., ... & Park, W. Y. (2020). Single-cell RNA sequencing reveals the tumor microenvironment and facilitates strategic choices to circumvent treatment failure in a chemorefractory bladder cancer patient. Genome medicine, 12, 1-21.
22. Kyeung-Min, J. O. O., Nam, H., Nam, D. H., Seung-Chyul, H. O. N. G., & Je-Young, Y. E. O. N. (2019). U.S. Patent Application No. 16/487,458.
23. Lee, Y. I., Kim, Y. G., Pyeon, H. J., Ahn, J. C., Logan, S., Orock, A., ... & De&225k, F. (2019). Dysregulation of the SNARE-binding protein Munc18-1 impairs BDNF secretion and synaptic neurotransmission: a novel interventional target to protect the aging brain. Geroscience, 41, 109-123.
24. Yun, J. W., Bae, Y. K., Cho, S. Y., Koo, H., Kim, H. J., Nam, D. H., ... & Park, W. Y. (2019). Elucidation of novel therapeutic targets for acute myeloid leukemias with RUNX1-RUNX1T1 fusion. International Journal of Molecular Sciences, 20(7), 1717.
25. Sa, J. K., Kim, S. H., Lee, J. K., Cho, H. J., Shin, Y. J., Shin, H., ... & Nam, D. H. (2019). Identification of genomic and molecular traits that present therapeutic vulnerability to HGF-targeted therapy in glioblastoma. Neuro-oncology, 21(2), 222-233.
26. Yeon, J. Y. Hwang, J. Y. Lee, H. W. Pyeon, H. J. Won, J. S. Noh, Y. J. Nam, H. Joo, K. M., Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells. Int J Mol Sci 2018, 19, (11).
27. Won, J. S. Yeon, J. Y. Pyeon, H. J. Noh, Y. J. Hwang, J. Y. Kim, C. K. Nam, H. Lee, K. H. Lee, S. H. Joo, K. M., Optimal Preclinical Conditions for Using Adult Human Multipotent Neural Cells in the Treatment of Spinal Cord Injury. Int J Mol Sci 2021, 22, (5).
28. Kim, S. S. Pyeon, H. J. Bae, Y. K. Nam, H. Kim, C. K. Lee, S. H. Joo, K. M., Adult Human Multipotent Neural Cells Could Be Distinguished from Other Cell Types by Proangiogenic Paracrine Effects via MCP-1 and GRO. Stem Cells Int 2021, 2021, 6737288.
29. Nam, H. Lee, I. H. Sa, J. K. Kim, S. S. Pyeon, H. J. Lee, K. H. Lee, K. Lee, S. H. Joo, K. M., Effects of Long-Term In Vitro Expansion on Genetic Stability and Tumor Formation Capacity of Stem Cells. Stem Cell Rev Rep 2022, 18, (1), 241-257.
30. Kim, C. K. Hwang, J. Y. Hong, T. H. Lee, D. M. Lee, K. Nam, H. Joo, K. M., Combinational stem cell therapy for critical hindlimb ischemia using dental pulp stem cells and human umbilical vein endothelial cells. BMB Rep 2022.