SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Seonghyun Lee
Seonghyun Lee PhD
| Graduate Program | Data Science and Personalized Medicine |
| Research Area | Mitochondria, Genome Editing |
| Laboratory | Mitochondrial Biotechnology Lab Laboratory |
| shlee9@skku.edu | |
| Tel | 031-299-6185 |
Education & Careers
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<EDUCATION>
2014-2020 Ph.D., Department of Chemistry, Sogang University, Republic of Korea, Integrated master’s and Ph.D. program (Advisor: Prof. Kyubong Jo, Ph.D.)
2010-2014 B.S., Chemical and Biomolecular Engineering / Interdisciplinary Program of Integrated Biotechnology, Sogang University, Republic of Korea
<CURRENT AND PREVIOUS POSITION>
2023.09-Current, Assistant Professor, Department of Precision Medicine, Sungkyunkwan University School of Medicine
2022.08-2023.08 Principal Researcher, R&D Team Manager, Edgene Incorporation, Seoul, South Korea (Founder: Jin-Soo Kim, Ph.D.)
2022.03-2022.08 Senior Research Fellow, Animal Team Leader, Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea
2020.03-2022.02 Senior Researcher, Center for Genome Engineering, Institute for Basic Science, Daejeon, South Korea (Director: Jin-Soo Kim, Ph.D.
Research Interest
- Protein Engineering for Better Performance in Genome Engineering
- Mouse Model for Genetic Disease
- Therapeutic Mitochondrial Genome Editing
Our group is researching cutting-edge biotechnology related to mitochondria and aiming to develop novel genome editing proteins for mitochondrial science. Also, our team is dedicated to refining genome editing techniques through advanced protein engineering. This improvement in DNA editing tools is crucial for achieving effective genome modifications. Additionally, our goal involves generating mice with edited mitochondrial DNA carrying specific mitochondrial diseases, and exploring potential therapeutic mitochondrial DNA editing. By utilizing reliable tools to introduce point mutations in mouse embryos, we can explore the consequences of various mitochondrial DNA mutations.
- Mouse Model for Genetic Disease
- Therapeutic Mitochondrial Genome Editing
Our group is researching cutting-edge biotechnology related to mitochondria and aiming to develop novel genome editing proteins for mitochondrial science. Also, our team is dedicated to refining genome editing techniques through advanced protein engineering. This improvement in DNA editing tools is crucial for achieving effective genome modifications. Additionally, our goal involves generating mice with edited mitochondrial DNA carrying specific mitochondrial diseases, and exploring potential therapeutic mitochondrial DNA editing. By utilizing reliable tools to introduce point mutations in mouse embryos, we can explore the consequences of various mitochondrial DNA mutations.
Representative Research Achievements
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- Seonghyun Lee, Hyunji Lee, Gayoung Baek, Jin-Soo Kim “Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors”, Nature Biotechnology, 2022, 41, 378-386, 10.1038/ s41587-022-01486-w, IF = 46.9
- Seonghyun Lee*, Hyunji Lee*, Gayoung Baek, Eunji Namgung, Joo Min Park, Sanghun Kim, Seongho Hong, Jin-Soo Kim “Enhanced mitochondrial DNA editing in mice using nuclear-exported TALE-linked deaminases and nucleases”, Genome Biology, 2022, 23, 211, 10.1186/s13059-022-02782-z, IF = 12.3
- Sung-Ik Cho, Seonghyun Lee, Young Geun Mok, Kayeong Lim, Jaesuk Lee, Ji Min Lee, Eugene Chung, and Jin-Soo Kim “Targeted A-to-G base editing in human mitochondrial DNA with programmable deaminases”, Cell, 2022, 185(10), 1764-1776. e12, IF = 64.5
- Hyunji Lee*, Seonghyun Lee*, Gayoung Baek, Annie Kim, Beum-Chang Kang, Huiyun Seo, Jin-Soo Kim “Mitochondrial DNA editing in mice with DddA-TALE fusion deaminases”, Nature Communications, 2021, 12, 1190, IF = 17.694 *Equally Contributed