SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
Professor
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Heeju Ryu
Heeju Ryu PhD
| Graduate Program | Infection and Immunity |
| Research Area | Human Immunology, Bioinformatics, Cancer Immunology |
| Laboratory | NextGen Immunogenomics |
| heejuryu@skku.edu | |
| Tel | +82-31-299-6078 |
Education & Careers
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2024 - current Assistant Professor, Sungkyunkwan University
2024 Postdoctoral Fellow, Fred Hutchinson Cancer Center
2019 PhD in Pharmacy, Seoul National University
2013 BS in Chemistry, University of Michigan
Research Interest
- Investigate Molecular cues to guide T cell function and differentiation
- Identify novel T cell subsets and their spatial organization using in situ spatial transcriptomics
- Develop novel immunotherapeutic strategies in cancer and virus-mediated diseases
- Utilize AI-powered approaches for comprehensive TCR/BCR analysis
- Identify novel T cell subsets and their spatial organization using in situ spatial transcriptomics
- Develop novel immunotherapeutic strategies in cancer and virus-mediated diseases
- Utilize AI-powered approaches for comprehensive TCR/BCR analysis
Representative Research Achievements
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1. Ryu et al., 2024. Merkel cell polyomavirus-specific and CD39+CLA+ CD8 T cells as blood-based predictive biomarkers for PD-1 blockade in Merkel cell carcinoma. Cell Reports Medicine.
2. Mayer-Blackwell K, Ryu et al., 2023 mRNA vaccination boosts S-specific T cell memory and promotes expansion of unique CD45RAint TEMRA-like CD8+ T cells in COVID-19 recovered individuals. Cell Reports Medicine.
3. Kim, Ryu et al., 2022. Real-time ultra-sensitive detection of SARS-CoV-2 by quasi-freestanding epitaxial graphene-based biosensor. Biosens Bioelectron.
4. Ma et al., 2021. Protracted yet coordinated differentiation of long-lived SARS-CoV-2-specific CD8+ T cells during COVID-19 convalescence. Journal of Immunology.
5. Park et al., 2019. IL-27 confers a protumorigenic activity of regulatory T cells via CD39. PNAS.
6. Ryu et al., 2018. Atherogenic dyslipidemia promotes autoimmune follicular helper T cell responses via IL-27. Nat Immunol.