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Jae-Hyun Park
Jae-Hyun Park PhD
Professor: Graduate Program, Research Area, Laboratory, E-mail, Tel
Graduate Program Neuroscience
Research Area
Laboratory Biomolecular Structural Biology Laboratory Laboratory
E-mail jaehyun234@skku.edu
Tel +82-31-299-6079
Education & Careers
  • 2024.03-present Assistant Professor, Department of Molecular Cell Biology, Sunkyunkwan University School of Medicine, Republic of Korea
    2021.04-2024.02 Post-doctoral Researcher, Department of Medical Life Scicences, Yokohama City University, Japan
    2021.03-2021.04 Post-doctoral Researcher, Department of Biochemistry, Yonsei University, Republic of Korea
    2014.03-2021.02 Ph.D in Biochemistry, Department of Biochemistry, Yonsei University, Republic of Korea (Advisor: Prof. Weontae Lee)
    2010.03-2014.02 B.S in Biochemistry, Department of Biochemistry, Yonsei University, Republic of Korea
Research Interest
초저온전자현미경 (cryo-electron microscopy cryo-EM) 및 X선 결정학 (X-ray crystallography)을 이용한 생체분자의 삼차원 구조를 규명합니다. 삼차원 구조를 토대로 생체분자의 작동 기작을 밝히고 나아가 특정 생체분자에 결합하는 치료제 유효, 후보, 선도물질의 발굴 및 작용 기작을 규명합니다.

-G-단백질 연결 수용체 (G-protein coupled receptor GPCR)의 삼차원 구조 및 신호전달기작 규명
-바이러스 수용체 및 바이러스 단백질의 삼차원 구조 및 생체 내 감염 원리 규명 - 바이러스 감염억제 유효물질 발굴
-세포막 Transporter의 삼차원 구조 및 작동원리 규명
-질병 관련 단백질의 삼차원 구조 규명 및 유효물질 발굴
Representative Research Achievements
  • 1. Jinta Asami†, Jae-Hyun Park†, Yayoi Nomura†, Chisa Kobayashi†, Junki Mifune, Naito Ishimoto, Tomoko Uemura, Kehong Liu, Yumi Sato, Zhikuan Zhang, Masamichi Muramatsu, Takaji Wakita, David Drew, So Iwata, Toshiyuki Shimizu, Koichi Watashi*, Sam-Yong Park*, Norimichi Nomura* & Umeharu Ohto* (2024) Structural basis of hepatitis B virus receptor binding. Nature Structural & Molecular Biology

    2. Jae-Hyun Park†, Kouki Kawakami†, Naito Ishimoto, Tatsuya Ikuta, Mio Ohki, Toru Ekimoto, Mitsunori Ikeguchi, Dong-Sun Lee, Young-Ho Lee, Jeremy R.H. Tame, Asuka Inoue*, Sam-Yong Park* (2023) Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2. Nature Communications

    3. Naito Ishimoto†, Jae-Hyun Park†, Kouki Kawakami, Michiko Tajiri, Kenji Mizutani, Satoko Akashi, Jeremy R. H. Tame, Asuka Inoue, Sam-Yong Park* (2023) Structural basis of CXC chemokine receptor 1 ligand binding and activation. Nature Communications

    4. Jae-Hyun Park, Masashi Iwamoto, Ji-Hye Yun, Tomomi Uchikubo-Kamo, Donghwan Son, Zeyu Jin, Hisashi Yoshida, Mio Ohki, Naito Ishimoto, Kenji Mizutani, Mizuki Oshima, Masamichi Muramatsu, Takaji Wakita, Mikako Shirouzu, Kehond Liu, Tomoko Uemura, Norimichi Nomura, So Iwata, Koichi Watashi, Jeremy R. H. Tame, Tomoyuki Nishizawa, Weontae Lee*, Sam-Yong Park* (2022) Structural insights into the HBV receptor and bile acid transporter NTCP. Nature

    5. Yunseok Heo, Inhwan Lee, Sunjin Moon, Ji-Hye Yun, Eun Yu Kim, Sam-Yong Park, Jae-Hyun Park, Woo Taek Kim*, Weontae Lee* (2022) Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain Molecules

    6. Ji-Hye Yun†, Xuanxuan Li†, Jianing Yue, Jae-Hyun Park, Zeyu Jin, Chufeng Li, Hao Hu, Yingchen Shi, Suraj Pandey, Sergio Carbajo, Sebastien Boutet, Mark S. Hunter, Mengning Liang, Raymond G. Sierra, Thomas J. Lane, Liang Zhou, Uwe Weierstall, Nadia A. Zatsepin, Mio Ohki, Jeremy R. H. Tame, Sam-Yong Park, John C. H. Spence, Wenkai Zhang, Marius Schmidt, Weontae Lee*, Haiguang Liu* (2021) Early-stage dynamics of chloride ion-pumping rhodopsin revealed by a femtosecond X-ray laser. Proceedings of the National Academy of Sciences of the United States of America

    7. Jeongmin Han†, Taehee Kim†, Sunjin Moon, Jae-Hyun Park, Wonbin Lee, Yoon-joo Ko, Kyoung-Seok Ryu, Ji-Hye Yun*, Weontae Lee* (2021) NMR spectroscopy uncovers direct interaction between BAF60A and p53. Biochemical and Biophysical Research Communications

    8. Ji-Hye Yun†, Mio Ohki†, Jae-Hyun Park, Naito Ishimoto, Ayana Sato-Tomita, Wonbin Lee, Zeyu Jin, Jeremy R. H. Tame, Naoya Shibayama, Sam-Yong Park*, Weontae Lee*, (2020) Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family. Science Advances

    9. Yunseok Heo, Jae-Hyun Park, Jongmin Kim, Jeongmin Han, Ji-Hye Yun*, Weontae Lee* (2020) Crystal structure of the HMG domain of human BAF57 and its interaction with four-way junction DNA. Biochemical and Biophysical Research Communications

    10. Pankaj Attri†*, Jae-Hyun Park, Joey De Backer, Myeongkyu Kim, Ji-Hye Yun, Yunseok Heo, Sylvia Dewilde, Masaharu Shiratani, Eun Ha Choi, Weontae Lee*, Annemie Bogaerts (2020) Structural modification of NADPH oxidase activator (Noxa 1) by oxidative stress: An experimental and computational study. International Journal of Biological Macromolecules

    11. Ji-Hye Yun†, Jae-Hyun Park†, Zeyu Jin†, Mio Ohki, Yang Wang, Cecylia Severin Lupala, Haigunag Liu, Sam-Yong Park, Weontae Lee*., (2020) Structure-Based Functional Modification Study of a Cyanobacterial Chloride Pump for Transporting Multiple Anions. Journal of Molecular Biology

    12. Jeongmin Han†, Iktae Kim†, Jae-Hyun Park, Ji-Hye Yun, Keehyoung Joo, Taehee Kim, Gye-Young Park, Kyoung-Seok Ryu, Yoon-Joo Ko, Kenji Mizutani, Sam-Young Park, Rho Hyun Seong, Jooyoung Lee*, Jeong-Yong Suh*, Weontae Lee* (2020) A coil-to-helix transition serves as a binding motif for hSNF5 and BAF155 interaction. International Journal of Molecular Sciences

    13. Jae-Hyun Park†, Ji-Hye Yun†, Yingchen Shi, Jeongmin Han, Xuanxuan Li, Zeyu Jin, Taehee Kim, Jaehyun Park, Sehan Park, Haiguang Liu*, Weontae Lee* (2019) Non-Cryogenic structure and dynamics of HIV-1 integrase catalytic core domain by X-ray free-electron lasers. International Journal of Molecular Sciences

    14. Yang Wang†, Jae-Hyun Park†, Cecylia Severin Lupala, Ji-Hye Yun, Zeyu Jin, Lanqing Huang, Xuanxuan Li, Leihan Tang, Weontae Lee*, Haiguang Liu* (2019) Computer aided protein engineering to enhance the thermo-stability of CXCR1-T4 lysozyme complex. Scientific Reports

    15. Ji-Hye Yun†, Xuanxuan Li†, Jae-Hyun Park, Yang Wang, Mio Ohki, Zeyu Jin, Wonbin Lee, SamYong Park, Hao Hu, Chufeng Li, Nadia Zatsepin, Mark S. Hunter, Raymond G. Sierra, Jake Koralek, Chun Hong Yoon, Hyun-Soo Cho, Uwe Weierstall, Leihan Tang, Haiguang Liu*, Weontae Lee* (2019) Non-cryogenic structure of a chloride pump provides crucial clues to temperature-dependent channel transport efficiency. Journal of Biological Chemistry

    16. Yang Wang, Cecylia Severin Lupala, Ting Wang, Xuanxuan Li, Ji-Hye Yun, Jae-Hyun Park, Zeyu Jin, Weontae Lee, Leihan Tan, Haiguang Liu* (2018) A computational study of the chemokine receptor CXCR1 bound with interleukin-8. Chinese Physics B

    17. Ji-Hye Yun, Kuglae Kim, Youngjin Jung, Jae-Hyun Park, Hyun-Soo Cho, Weontae Lee* (2014) Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor. Biochemical and Biophysical Research Communications

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