SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Professor
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Kyeong Kyu Kim
Kyeong Kyu Kim PhD
| Graduate Program | Biomedical Therapeutics |
| Research Area | Structural Biology/ Regenerative Medicine/ Antimicrobial Resistance/New Therapeutics/Noncanonical DNA |
| Laboratory | Structure Biology Laboratory Laboratory |
| kyeongkyu@skku.edu | |
| Tel | +82-31-299-6136 |
Education & Careers
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2000~Present Professor, Sungkyunkwan University School of Medicine
1998-2000 Assistance professor, Gyeongsang National University
1993-1998 UC Berkeley Post-Doc
1985-1993 Bachelor, Master and PhD Seoul National University (Biochemistry)
Research Interest
Out research goal is to understand the causes of diseases at the molecular level and to develop patient or customized precision therapeutics. We are investigating the biological phenomena or cause of diseases via the interaction of biological molecules such as DNA, protein and metabolites by applying the structural and chemical biology approaches, which allow us to observe the molecules in detail and control their functions. Our main topics are following (1) research on the ubiquitin-dependent protein stability control of cancer related proteins and development of cancer therapeutics targeting ubiquitin pathway (2) understanding the structural and functional roles of the noncanonical DNAs in the genome and their regulation in cancers (3) development of novel antibacterial therapeutics to overcome antibiotic resistance and (4) regenerative medicine research using the patient-specific cell therapies.
Representative Research Achievements
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<Recent Representative Papers>
1. G-quadruplex-dependent transcriptional regulation by molecular condensation in the Bcl3 promoter.
Nucleic Acids Research 2025 August 30, https://doi.org/10.1093/nar/gkaf827
2. In vivo brown adipogenic reprogramming induced by a small molecule cocktail
Biomaterials 2025 Jun 2. doi.org/10.1016/j.biomaterials.2025.123463
3.Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus.
J Biomed Sci. 2025 Feb 532(1):15. doi: 10.1186/s12929-024-01109-3.
4. Cryo-EM structure of a 16.5-kDa small heat-shock protein from Methanocaldococcus
Int J Biol Macromol. 2024 Feb258(Pt 1):128763. doi: 10.1016/j.ijbiomac.2023.128763.
5. Molecular basis for SOX2-dependent regulation of super-enhancer activity.
Nucleic Acids Research, 2023 Nov 01. doi.org/10.1093/nar/gkad908
6. Towards Visualizing Genomic DNA Using Electron Microscopy via DNA Metallization.
Small structure 2023 March. doi: 10.1002/sstr.202200361.