SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Ho-Chang Jeong
Ho-Chang Jeong PhD
| Graduate Program | Development and Regenerative Medicine |
| Research Area | Hematopoietic development, Disease modeling, Human embryonic stem cells, iPSCs |
| Laboratory | Pluripotency to Blood Lab (PBL) Laboratory |
| hcjeong@skku.edu | |
| Tel | +82-31-299-6071 |
Education & Careers
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2024 - Sungkyunkwan University School of Medicine, Assistant Professor
2023 - 2024 Washington University in St. Louis, USA, Staff Scientist
2018 - 2023 Washington University in St. Louis, USA, Post-doctoral Fellow
2017 - 2018 Sogang University Research Institute for Basic Science, Associate Researcher
2014 - 2017 Sogang University Department of Life Sciences, Ph.D.
2012 - 2014 Sogang University Department of Life Sciences, MS
2005 - 2011 Kyung Hee University College of Life Sciences Department of Priental Medicine Biotechnology, BS
Research Interest
1. Human PSC-derived hematopoietic disease modeling
2. Unraveling the pathogenic mechanism and drug development
3. Applications of hPSC-derived bone marrow organoids
4. Development and heterogeneity of hematopoietic stem cells
2. Unraveling the pathogenic mechanism and drug development
3. Applications of hPSC-derived bone marrow organoids
4. Development and heterogeneity of hematopoietic stem cells
Representative Research Achievements
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1. Jeong HC*, Shukla S*, Fok WC, Huynh TN, Batista LFZ, Parker R “USB1 is a miRNA deadenylase that regulates hematopoietic development” Science. 2023 379(6635): 901-7. (Research Highlighted by Nature Review Genetics: https://www.nature.com/articles/s41576-023-00595-9)
2. Jeong HC*, Go YH*, Shin JG, Kim YJ, Cho MG, Gwon D, Cheong HS, Lee H, Lee JH, Jang CY, Shin HD, Cha HJ “TPX2 amplification-driven aberrant mitosis in culture adapted human embryonic stem cells with gain of 20q11.21” Stem Cell Rev Rep. 2023 doi: 10.1007/s12015-023-10514-4.
3. Shukla S*, Jeong HC*, Sturgeon CM, Parker R, Batista LFZ “Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita” Blood Adv. 2020 4(12): 2712-22.
4. Jeong HC, Park SJ, Choi JJ, Go YH, Hong SK, Kwon OS, Shin JG, Kim RK, Lee MO, Lee SJ, Shin HD, Moon SH, Cha HJ “PRMT8 controls the pluripotency and mesodermal fate of human embryonic stem cells by enhancing the PI3K/AKT/SOX2 axis” Stem Cells. 2017 35(9): 2037-49.
5. Jeong HC, Cho SJ, Lee MO, Cha HJ “Technical approaches to induce selective cell death of pluripotent stem cells” Cell Mol Life Sci. 2017 74(14): 2601-11. (Invited Review)
6. Yea CH*, Jeong HC*, Moon SH, Lee MO, Kim KJ, Choi JW, Cha HJ “In situ label-free quantification of human pluripotent stem cells with electrochemical potential” Biomaterials. 2016 75: 250-9.
7. Jeong HC, Gil NY, Lee HS, Cho SJ, Kim K, Chun KH, Cho H, Cha HJ “Timely degradation of Wip1 phosphatase by APC/C activator protein Cdh1 is necessary for normal mitotic progression” J Cell Biochem. 2015 116(8): 1602-12.