SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Seong-Kyun Lee
Seong-Kyun Lee PhD
| Graduate Program | Parasitology |
| Research Area | Malaria biology / vaccines |
| Laboratory | Laboratory of Parasite Biology |
| seongkyunlee@skku.edu | |
| Tel | +82 31-299-6122 |
Education & Careers
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2007 &8211 2013: B.Sc. in Biotechnology, Kangwon National University, Korea
2013 &8211 2020: Ph.D. in Parasitology, Kangwon National University, Korea
2020 &8211 2025: Postdoctoral Research Fellow, National Institutes of Health (NIH), USA
2025 &8211 Present: Assistant Professor, Department of Microbiology, School of Medicine, Sungkyunkwan University, Korea
Research Interest
We seek scientific breakthroughs in the study of malaria parasites by developing next-generation vaccines and innovative diagnostic tools to control and ultimately eliminate vivax malaria. To accomplish this goal, we are interested in
1. Developing durable malaria vaccines using virus-like particles (VLPs) to induce strong and long-lasting immune responses.
2. Identifying novel vaccine candidates by characterizing parasite surface proteins and their roles in reticulocyte invasion.
3. Advancing malaria diagnostics by designing sensitive and specific molecular and serological assays for both clinical and asymptomatic infections.
4. Understanding antigenic diversity and immune evasion of Plasmodium vivax through structural, functional, and population-level analyses.
1. Developing durable malaria vaccines using virus-like particles (VLPs) to induce strong and long-lasting immune responses.
2. Identifying novel vaccine candidates by characterizing parasite surface proteins and their roles in reticulocyte invasion.
3. Advancing malaria diagnostics by designing sensitive and specific molecular and serological assays for both clinical and asymptomatic infections.
4. Understanding antigenic diversity and immune evasion of Plasmodium vivax through structural, functional, and population-level analyses.
Representative Research Achievements
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- Lee SK*, Crosnier C, Valenzuela-Leon PC, Dizon BLP, Atkinson JP, Mu J, Wright GJ, Calvo E, Gunalan K, Miller LH. 2024. Complement receptor 1 is the human erythrocyte receptor for Plasmodium vivax erythrocyte binding protein. Proc Natl Acad Sci USA. 121(5)
- Lee SK*, Nguyen TK, Mohring F, Han JH, Firdaus ER, Na SH, Park WS, Moon RW, Han ET. 2023. Merozoite surface protein 1 paralog is involved in the human erythrocyte invasion of a zoonotic malaria, Plasmodium knowlesi. Front Cell Infect Microbiol. 13:1314533
- Lee SK*, Low LM, Andersen JF, Yeoh LM, Valenzuela Leon PC, Drew DR, Doehl JSP, Calvo E, Miller LH, Beeson JG, Gunalan K. 2023. The direct binding of Plasmodium vivax AMA1 to erythrocytes defines a RON2-independent invasion pathway. Proc Natl Acad Sci USA. 120(1):e2215003120