Hyun-Jin Kim
Hyun-Jin Kim PhD
Professor: Graduate Program, Research Area, Laboratory, E-mail, Tel
Graduate Program Neuroscience
Research Area Ion channels, Autophagy
Laboratory Molecular Neurophysiology Lab Laboratory
Tel +82-31-299-6105
Education & Careers
  • 2010 ~Present Assistant, Associate Professor, Sungkyunkwan University School of Medicine, Suwon, Korea
    2006 -2010 Post-doc, University of Texas Southwestern Medical Center at Dallas, TX, USA
    2001 -2006 PhD, Department of Physiology, Seoul National University College of Medicine, Seoul, Korea
    1994 -2000 MD, Seoul National University College of Medicine, Seoul, Korea
Research Interest
1) Ion channels
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by gating the flow of ions across the cell membrane, controlling the flow of ions across secretory and epithelial cells, and regulating cell volume. Ion channels are present in the membranes of all cells. We are now interested in understanding function of Transient Receptor Potential (TRP) channels which have been implicated in a diverse range of cellular processes.

2) Autophagy
Autophagy is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components. It allows the orderly degradation and recycling of cellular components. Defects in autophagy have been linked to various human diseases, including neurodegeneration and cancer, and interest in modulating autophagy as a potential treatment for these diseases has grown rapidly. Our research focuses on the regulation of autophagy by one of TRP channels in mammalian cells.
Representative Research Achievements
  • 1. N&8208benzhydryl quinuclidine compounds are a potent and Src kinase&8208independent inhibitor of NALCN channels. Br J Pharmacol. 2020 Aug177(16):3795-3810.

    2. Palmitoylation controls trafficking of the intracellular Ca2+ channel MCOLN3/TRPML3 to regulate autophagy. Autophagy. 201915(2):327-340.

    3. Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers. Sci Rep. 2018 Aug 148(1):12117.

    4. TLR3-/4-Priming Differentially Promotes Ca(2+) Signaling and Cytokine Expression and Ca(2+)-Dependently Augments Cytokine Release in hMSCs. Sci Rep. 2016 Mar 166:23103

    5. The Ca2+ channel TRPML3 specifically interacts with the mammalian ATG8 homologue GATE16 to regulate autophagy. Biochem Biophys Res Commun. 2014443(1):56-61.

    6. Isoform- and receptor-specific channel property of canonical transient receptor potential(TRPC)1/4 channels. Pflugers Arch. 2014 Mar:466(3):491-504.