SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Laboratory
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MBTL - Mitochondrial Biotechnology Lab
Mitochondrial Biotechnology via Genome Editing
- Protein Engineering for Better Performance in Genome Engineering
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Our research interest consists of using drug delivery technology to improve the therapeutic effect of cytomedicine following transplantation.
Our research topi..
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Membrane organelles are well-known examples of lipid bilayer-based compartmentalization.
Biomolecular condensates, on the other hand, are structures formed th..
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In this laboratory, we are studying the mechanism of regulation of ion channel proteins as the cause of cardiac arrhythmias and various neurological diseases.
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Parkinson disease (PD) is the most common neurodegenerative movement disorder. Although L-DOPA treatment is applied to alleviate motor deficit in PD patients, t..
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Alzheimer’s Disease (AD) is a typical neurodegenerative disease caused by increased amyloid b-protein (Ab) production. One of main genetic cause of AD is mutati..
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The long-term goal of Dr. Im’s research is to understand the mechanisms of T cell immunity in disease models having highly sustained antigen levels such as chro..
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1. Tumor biology and Anti-tumor immunity
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity and ..
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The main pathological features common to obesity and diabetes are the deregulation of nutrient and energy homeostasis. Studying the signaling pathways involved ..
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In molecular virology lab, we study the gene function and interaction with host of human cytomegalovirus (HCMV) that causes several diseases in patients with co..
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1) Mechanism of dopaminergic neuronal death
2) Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
3) Relationship between neur..
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1) Ion channels
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a restin..
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1. Impact of climate change on the outbreak of infectious diseases
2. Epidemiological risk factors related to the epidemic of infectious diseases
3. Predictio..
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Acinetobacter baumannii&160received very little attention until the 1990s. Since its low virulence, it was not considered as a pathogenic bacteria. During the 2..
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Ion channels and transporters, Intracellular Ca2+ signaling
Channelopathy of hearing loss (KCNQ4 channelopathy)
Cardiac arrhythmias, hERG assay and cardiotoxi..
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1. Translesion DNA synthesis (TLS) across carcinogen-modified DNA lesions by DNA polymerases.
2. The role of human DNA polymerases & their genomic variations i..
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We are working to develop and improve CRISPR-based genome editing technologies.
Our current research focuses on profiling and improving the genome-wide specif..
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Laboratory of Molecular Immunology
Our laboratory conducts basic and translational studies related to innate immunity and cancer immunotherapy.
We have mad..
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Medical & population genomics
Since the Human Genome Project, genome-wide association studies (GWAS) have been successful in identifying common genetic variant..
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The immune response monitors and destroys infections and tumors, but at the same time maintains the bodys homeostasis.
When this homeostasis is disrupted, aut..
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The goal of the research in my laboratory is to understand the molecular regulatory pathways that control proliferation and differentiation of stem cells during..
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The goal of our research is to identify the fundamental mechanisms and principles that govern neuronal death and connectivity of neural circuits in the brain de..
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[1] Angiogenesis is implicated in the development of various diseases including cancer. Currently, we are working on the role of various signaling pathways, esp..
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We are witnessing the beginning of a new generation of medicine. The unprecedented amount of large-scale next generation sequencing data from patients with canc..
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Out research goal is to understand the causes of diseases at the molecular level and to develop patient or customized precision therapeutics. We are investigati..
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Hepatitis B virus (HBV) infection causes chronic hepatitis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC). It is a major health problem with over 350..
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