SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Laboratory
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The Laboratory of Healthy Aging and Epigenetics is extensively conducting research, in collaboration with various domestic and international institutions, on ac..
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Our research interest consists of using drug delivery technology to improve the therapeutic effect of cytomedicine following transplantation.
Our research topi..
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Mesenchymal stem cell therapies have been studied in some diseases which are cancer, neurological pathologies, musculoskeletal disorders etc. as alternative opt..
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We have focused on disease modeling through human pluripotent stem cell (embryonic stem cell and induced pluripotent stem cell (iPSC))-derived hematopoiesis and..
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1) Researches about health policy and management
We conduct researches about public health status, policy, and management, payment system design, health care q..
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초저온전자현미경 (cryo-electron microscopy cryo-EM) 및 X선 결정학 (X-ray crystallography)을 이용한 생체분자의 삼차원 구조를 규명합니다. 삼차원 구조를 토대로 생체분자의 작동 기작을 밝히고 나아가 특정 생체분자에 결합하는 치료제 유효, 후보..
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만성폐쇄성폐질환(chronic obstructive pulmonary disease, COPD)
흡연에 의한 폐의 만성염증성질환인 COPD는 현재 국내 10대 사망요인이며, 2010년에는 세계적으로 사망 및 불구를 유발하는 4위의 질환이 될 것으로 전망하고 있다. 적극적인 금연 운..
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- Protein Engineering for Better Performance in Genome Engineering
- Mouse Model for Genetic Disease
- Therapeutic Mitochondrial Genome Editing
Our group i..
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Our lab focuses on studying molecular mechanisms underlying survival of Salmonella, a Gram (-) pathogen, inside host cells.
1. Iron regulation of Salmonella vi..
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1. Research objective 1: Employment of various biomaterials and biofabrication systems for regenerative medicine purposes.
We aim to fabricate functional hydro..
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Low complexity (LC) domain은 일반적으로 단순하고 반복적인 아미노산 조성으로 이루어진 단백질 내의 일부분을 지칭한다. 세포 내에서 transcription 및 translation을 조절하는 많은 RNA 또는 DNA binding protein들이 RNA나 DNA와의..
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Membrane organelles are well-known examples of lipid bilayer-based compartmentalization.
Biomolecular condensates, on the other hand, are structures formed th..
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In this laboratory, we are studying the mechanism of regulation of ion channel proteins as the cause of cardiac arrhythmias and various neurological diseases.
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Parkinson disease (PD) is the most common neurodegenerative movement disorder. Although L-DOPA treatment is applied to alleviate motor deficit in PD patients, t..
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Alzheimer’s Disease (AD) is a typical neurodegenerative disease caused by increased amyloid b-protein (Ab) production. One of main genetic cause of AD is mutati..
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The long-term goal of Dr. Im’s research is to understand the mechanisms of T cell immunity in disease models having highly sustained antigen levels such as chro..
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1. Tumor biology and Anti-tumor immunity
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity an..
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The main pathological features common to obesity and diabetes are the deregulation of nutrient and energy homeostasis. Studying the signaling pathways involved ..
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In molecular virology lab, we study the gene functions and host interactions of human cytomegalovirus (HCMV) that causes several diseases in patients with conge..
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1) Mechanism of dopaminergic neuronal death
2) Cellular and physiological roles of KRAB-zinc finger (K-ZNF) proteins in neurons
3) Relationship between neurod..
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1) Ion channels
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a restin..
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1. Impact of climate change on the outbreak of infectious diseases
2. Epidemiological risk factors related to the epidemic of infectious diseases
3. Predictio..
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Acinetobacter baumannii received very little attention until the 1990s. Since its low virulence, it was not considered as a pathogenic bacteria. During the 21st..
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- Ion channels and transporters, Intracellular Ca2+ signaling
- Channelopathy of hearing loss (KCNQ4 channelopathy)
- Cardiac arrhythmias, hERG assay and card..
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1. Translesion DNA synthesis (TLS) across carcinogen-modified DNA lesions by DNA polymerases.
2. The role of human DNA polymerases & their genomic variations i..
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We are working to develop and improve CRISPR-based genome editing technologies.
Our current research focuses on profiling and improving the genome-wide specif..
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Our laboratory conducts basic and translational studies related to innate immunity and cancer immunotherapy.
We have made major contributions to our underst..
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> Medical & population genomics
Since the Human Genome Project, genome-wide association studies (GWAS) have been successful in identifying common genetic va..
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The immune response monitors and destroys infections and tumors, but at the same time maintains the bodys homeostasis.
When this homeostasis is disrupted, aut..
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The goal of the research in my laboratory is to understand the molecular regulatory pathways that control proliferation and differentiation of stem cells during..
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Signaling networks regulating cell survival and dynamics in brain development and disease
The goal of our research is to identify the fundamental mechanisms ..
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1. Mechanisms underlying a broad cancer protection in Down syndrome individuals.
Many studies have shown that the Down syndrome population is protected agains..
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We are witnessing the beginning of a new generation of medicine. The unprecedented amount of large-scale next generation sequencing data from patients with canc..
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Out research goal is to understand the causes of diseases at the molecular level and to develop patient or customized precision therapeutics. We are investigati..
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Hepatitis B virus (HBV) infection causes chronic hepatitis, liver cirrhosis (LC), and hepatocellular carcinoma (HCC). It is a major health problem with over 350..
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Research of Neuronal Excitability and Calcium Signaling
도파민 신경세포 기능 연구
인간의 보상, 감정, 운동, 학습과 같은 고등기능에 중뇌 도파민신경세포는 깊게 관여하며, 도파민신경세포의 이상은 정신분열병, 알쯔하이머 병이나 파킨손질환..
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* Forensic Pathology & Genetics
- Mitochondrial variant analysis in cancer tissue
- Utilizing decomposed tissue in postmortem diagnosis
- Postmortem human id..
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1) Mechanisms of Inflammatory Response Regulation
2) Regulation of Protein Secretion..
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- DNA damage response pathway와 이에 의한 cell cycle checkpoint와 DNA repair의 조절 기전에 대한 이해
- 암의 직접적인 원인이 되는 genetic instability의 유발 기전에 대한 이해
- 암 치료제 개발을 위한 새로운 tar..
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Tumor microenvironment plays a key role in tumorigenesis, progression and clinical response through intercellular interactions. Single cell genome analysis enab..
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Rho small GTP binding protein을 통한 세포내 신호전달과정.
Rho family small G protein은 Ras superfamily에 속하는 guanine nucleotide결합 단백질로 Ras와는 다른 생리작용을 매개하는 단백질군이다. 이들은 세포골격..
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1) 신경펩타이드에 의한 신경세포의 성장 및 분화조절기전
신경펩타이드들은 성숙된 중추신경계통 내에서 신경세포의 흥분성을 조절하는 신경조절인자로서 작용하는 동시에, 신경계통의 발생과정 중에는 신경세포의 성장 및 분화를 조절하는 기능을 수행하는 것으로 알려져 있다. 현재 신경계통의 손상 ..
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1) 유방암 역학 (Breast Cancer Epidemiology)
유방암의 위험요인, 특히 식이요인이 유방암 발생 위험도에 미치는 영향을 역학적으로 평가
2) 만성병 질병통계 (Descriptive Epidemiology for Chronic Diseases)
만성질환, 특..
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저희 연구실은 빅데이터와 인공지능 기술을 통한 4차 산업시대 의학기술의 혁신을 추구하고 있습니다.
1. 국내외 글로벌 의료 빅데이터 분석 (전국민, 전세계, Bias-Free를 추구하는 깊고 넓은 대규모 의료 빅데이터 연구방법)
2. 디지털 헬스케어/차세대 의료 연구 (웨어러블, 모..
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인체의 정상구조와 변이, 특히 근육골격계통의 임상해부학에 관심을 갖고 있다. MR 촬영후, 연속절단 및 해부를 통해 얻어진 결과를 비교함으로써, 어떤 구조가 영상의학적으로 보여지는 image를 얻는데 역점을 두고 있다. 근래는 발에서 Lisfrac joint (발목발허리관절)의 인대를 ..
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- Investigate Molecular cues to guide T cell function and differentiation
- Identify novel T cell subsets and their spatial organization using in situ spatial ..
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