1. Tumor biology and Anti-tumor immunity
: Identifications of novel signaling pathways in tumor immunity and immune checkpoint regulation
2. Autoimmunity and autoimmune disease therapy
: Receptor-mediated signaling mechanism in regulating autoimmunity and the development of autoimmune disease therapeutic strategy
3. Hepatic metabolic disorders and hepatocellular carcinoma
: Study of novel molecular mechanism of steatohepatitis and hepatocellular carcinoma, and development of its relevant therapeutic strategy
[Selected Publications]
1. Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, and Lee CW. Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nature Communications, 2023, 14: 1097. (IF 17.694)
2. Park J, Lee SY, Jeon Y, Kim KM, Lee JK, ko J, Park EJ, Yoon JS, kang BE, Ryu D, Lee H, Shin SJ, Go H, and Lee CW. The Pellino1-PKCθ signaling axis is an essential target for improving antitumor CD8+ T-lymphocyte function. Cancer Immunology Research, 2022, 10(3):327-342. (IF 12.020)
3. Kim HS, Yoon JS, Jeon Y, Park EJ, Lee JK, Chen S, Lee H, Park JY, Go H, and Lee CW. Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma. Cell Death and Differentiation, 2022, 29(3):600-613. (IF 12.067)
4. Lee JK, Koo SY, Nam HM, Lee JB, Ko J, Kim KM, Park EJ, Kim TJ, Lee H, Go H and Lee CW. Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells. Cellular and Molecular Immunology, 2021, 18(6):1395-1411. (IF 22.096)
5. Ha GH, Ji JH, Chea S, Park J, Kim S, Lee JK, Kim Y, Min S, Park JM, Kang TH, Lee H, Cho H, Lee CW. Pellino1 regulates reversible ATM activation vio NBS1 ubiqutination at DNA double strand breaks. Nature Communications, 2019, 10(1):1577:1-14 (IF 17.694)
6. Kim SH, Jeon Y, Kim HS, Lee JK, Lim HJ, Kang D, Cho H, Park CK, Lee H, Lee CW. Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase. Hepatology, 2016, 63(1):247-259. (IF 17.298)
7. Park HY, Go H, Song HR, Kim S, Ha GH, Jeon YK, Kim JE, Lee H, Cho H, Kang HC, Chung HY, Kim CW, Chung DH, and Lee CW. Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. Journal of Clinical Investigation, 2014, 124(11):4976-4988. (IF 19.456)
8. Shin HJ, Baek KH, Jeon AH, Park MT, Lee SJ, Kang CM, Lee HS, Yoo SH, Chung DH, Sung YC, McKeon F, and Lee CW. Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. Cancer Cell 2003, 4(6):483-497. (IF 38.585)
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(Email) cwlee1234@skku.edu