Molecular Toxicology and Pharmacology Lab(분자독성약리학 연구실)

Jeong-Yun Choi

DNA 손상, 수복, 복제 및 유전 변이 Laboratory
분자독성약리학 연구실
1. Translesion DNA synthesis (TLS) across carcinogen-modified DNA lesions by DNA polymerases.
2. The role of human DNA polymerases & their genomic variations in mutagenesis & carcinogenesis.
3. Identification and development of anticancer therapy resistance gene markers, genotoxicity indexes and in vitro screening systems.
4. Interrelations of three R (DNA replication, repair, recombination) processes against DNA damage and its disease association.
1. Yeom M, et al., Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H2O2 Sensitivity in POLI-Deficient Cells. Chem Res Toxicol (2020) DOI: 10.1021/acs.chemrestox.0c00127

2. Choi JY, et al., Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase &61545. J Biol Chem (2016) 291(40):21063-21073.

3. Kim JK, et. Al., Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ. Chem Res Toxicol (2016) 29(10):1741-1754.

4. Kim J, et. Al., Biochemical Analysis of Six Genetic Variants of Error-Prone Human DNA Polymerase ι Involved in Translesion DNA Synthesis. Chem Res Toxicol (2014) 27(10):1837-52.

5. Choi JY, et al., Translesion synthesis across abasic lesions by human B-family and Y-family DNA polymerases α, δ, η, ι, κ, and REV1. J Mol Biol (2010) 404(1):34-44.
(Tel) 031-299-6193,  (Email)