SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
- Ion channels and transporters, Intracellular Ca2+ signaling
- Channelopathy of hearing loss (KCNQ4 channelopathy)
- Cardiac arrhythmias, hERG assay and cardiotoxicity
- Ion channel drug discovery
- Muscle Physiology (Cardiac muscle, Smooth muscle, Skeletal muscle)
- Nano-bionics and artificial muscles
- Channelopathy of hearing loss (KCNQ4 channelopathy)
- Cardiac arrhythmias, hERG assay and cardiotoxicity
- Ion channel drug discovery
- Muscle Physiology (Cardiac muscle, Smooth muscle, Skeletal muscle)
- Nano-bionics and artificial muscles
[Selected Publications]
1. Biomimetic cell-actuated artificial muscle with nanofibrous bundles. Microsyst Nanoeng. (2021) 7:70.
2. Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss. Exp Mol Med. (2021) 53(7):1192-1204.
3. Identification and characterization of a novel large-conductance calcium-activated potassium channel activator, CTIBD, and its relaxation effect on urinary bladder smooth muscle. Mol Pharmacol. (2021) 99(2):114-124.
4. Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane. Korean J Physiol Pharmacol. (2020) 24(6):529-543.
5. Two-Ply Carbon Nanotube Fiber-Typed Enzymatic Biofuel Cell Implanted in Mice. IEEE Trans Nanobioscience. (2020) 19(3):333-338.
6. Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes. Korean J Physiol Pharmacol. (2019) 23(6):539-547.
7. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep. (2018) 8:16659.
8. Biomolecule based fiber supercapacitor for implantable device. Nano Energy (2018) 47:385-392.
9. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci Rep. (2017) 7:40872.
10. Bio-inspired hybrid carbon nanotube muscles. Sci Rep. (2016) 6:26687.
11. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. (2013) 430(2):722-8.
12. Enhanced actuation of PPy/CNT hybrid fibers using porous structured DNA hydrogel. Sensors and Actuators B (2010) 145:89-92.
13. Fullerene attachment enhances performance of a DNA nanomachine. Adv. Mater. (2009) 21:1-4.
14. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metabolism (2008) 8(4)318-324.
15. Multiple transport modes of the cardiac Na+/Ca2+ exchanger. Nature (2004) 427(6974):544-548.
1. Biomimetic cell-actuated artificial muscle with nanofibrous bundles. Microsyst Nanoeng. (2021) 7:70.
2. Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss. Exp Mol Med. (2021) 53(7):1192-1204.
3. Identification and characterization of a novel large-conductance calcium-activated potassium channel activator, CTIBD, and its relaxation effect on urinary bladder smooth muscle. Mol Pharmacol. (2021) 99(2):114-124.
4. Nanoscale imaging of rat atrial myocytes by scanning ion conductance microscopy reveals heterogeneity of T-tubule openings and ultrastructure of the cell membrane. Korean J Physiol Pharmacol. (2020) 24(6):529-543.
5. Two-Ply Carbon Nanotube Fiber-Typed Enzymatic Biofuel Cell Implanted in Mice. IEEE Trans Nanobioscience. (2020) 19(3):333-338.
6. Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes. Korean J Physiol Pharmacol. (2019) 23(6):539-547.
7. Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss. Sci Rep. (2018) 8:16659.
8. Biomolecule based fiber supercapacitor for implantable device. Nano Energy (2018) 47:385-392.
9. Optogenetic modulation of urinary bladder contraction for lower urinary tract dysfunction. Sci Rep. (2017) 7:40872.
10. Bio-inspired hybrid carbon nanotube muscles. Sci Rep. (2016) 6:26687.
11. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. (2013) 430(2):722-8.
12. Enhanced actuation of PPy/CNT hybrid fibers using porous structured DNA hydrogel. Sensors and Actuators B (2010) 145:89-92.
13. Fullerene attachment enhances performance of a DNA nanomachine. Adv. Mater. (2009) 21:1-4.
14. Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metabolism (2008) 8(4)318-324.
15. Multiple transport modes of the cardiac Na+/Ca2+ exchanger. Nature (2004) 427(6974):544-548.
(Tel) +82-31-299-6102,
(Email) tongmkang@skku.edu