SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
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Laboratory
Structural Biology Laboratory(구조생물학연구실)
Kyeong Kyu Kim
Structural Biology Regenerative Medicine Antimicrobial Resistance Development of Therapeutics Laboratory
Out research goal is to understand the causes of diseases at the molecular level and to develop patient or customized precision therapeutics. We are investigating the biological phenomena or cause of diseases via the interaction of biological molecules such as DNA, protein and metabolites by applying the structural and chemical biology approaches, which allow us to observe the molecules in detail and control their functions. Our main topics are following (1) research on the ubiquitin-dependent protein stability control of cancer related proteins and development of cancer therapeutics targeting ubiquitin pathway (2) understanding the structural and functional roles of the noncanonical DNAs in the genome and their regulation in cancers (3) development of novel antibacterial therapeutics to overcome antibiotic resistance and (4) regenerative medicine research using the patient-specific cell therapies.
[Selected Publications]
1. Cryo-EM structure of a 16.5-kDa small heat-shock protein from Methanocaldococcus jannaschii.
Joohyun Lee, Bumhan Ryu, Truc Kim, Kyeong Kyu Kim.
International Journal of Biological Macromolecules. 15 December 2023, https://doi.org/10.1016/j.ijbiomac.2023.128763
2. Molecular basis for SOX2-dependent regulation of super-enhancer activity.
Yoo W, Song YW, Kim J, Ahn J, Kim J, Shin Y, Ryu JK, Kim KK.
Nucleic Acids Res. 2023 Nov 1:gkad908. doi: 10.1093/nar/gkad908.
3. Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression.
Razzaq M, Han JH, Ravichandran S, Kim J, Bae JY, Park MS, Kannappan S, Chung WC, Ahn JH, Song MJ, Kim KK.
Arch Pharm Res. 2023 Jul46(7):598-615. doi: 10.1007/s12272-023-01458-x. Epub 2023 Aug 10.
4. AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.
Hur JH, Kang CY, Lee S, Parveen N, Yu J, Shamim A, Yoo W, Ghosh A, Bae S, Park CJ, Kim KK.
Nucleic Acids Res. 2021 Sep 1:gkab728. doi: 10.1093/nar/gkab728
5. An Antibacterial Nanorobotic Approach for the Specific Targeting and Removal of Multiple Drug-Resistant Staphylococcus aureus.
Batool N, Yoon S, Imdad S, Kong M, Kim H, Ryu S, Lee JH, Chaurasia AK, Kim KK.
Small. 2021 Apr 10:e2100257. doi: 10.1002/smll.202100257.
1. Cryo-EM structure of a 16.5-kDa small heat-shock protein from Methanocaldococcus jannaschii.
Joohyun Lee, Bumhan Ryu, Truc Kim, Kyeong Kyu Kim.
International Journal of Biological Macromolecules. 15 December 2023, https://doi.org/10.1016/j.ijbiomac.2023.128763
2. Molecular basis for SOX2-dependent regulation of super-enhancer activity.
Yoo W, Song YW, Kim J, Ahn J, Kim J, Shin Y, Ryu JK, Kim KK.
Nucleic Acids Res. 2023 Nov 1:gkad908. doi: 10.1093/nar/gkad908.
3. Stabilization of RNA G-quadruplexes in the SARS-CoV-2 genome inhibits viral infection via translational suppression.
Razzaq M, Han JH, Ravichandran S, Kim J, Bae JY, Park MS, Kannappan S, Chung WC, Ahn JH, Song MJ, Kim KK.
Arch Pharm Res. 2023 Jul46(7):598-615. doi: 10.1007/s12272-023-01458-x. Epub 2023 Aug 10.
4. AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation.
Hur JH, Kang CY, Lee S, Parveen N, Yu J, Shamim A, Yoo W, Ghosh A, Bae S, Park CJ, Kim KK.
Nucleic Acids Res. 2021 Sep 1:gkab728. doi: 10.1093/nar/gkab728
5. An Antibacterial Nanorobotic Approach for the Specific Targeting and Removal of Multiple Drug-Resistant Staphylococcus aureus.
Batool N, Yoon S, Imdad S, Kong M, Kim H, Ryu S, Lee JH, Chaurasia AK, Kim KK.
Small. 2021 Apr 10:e2100257. doi: 10.1002/smll.202100257.
(Tel) +82-31-299-6136,
(Email) kyeongkyu@skku.edu