SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
The main pathological features common to obesity and diabetes are the deregulation of nutrient and energy homeostasis. Studying the signaling pathways involved in nutrient and energy homeostasis could lead to better understanding of pathophysiology of metabolic disorders. We are interested in understanding how cells sense and integrate signals from growth factors and from nutrients to mediate metabolic responses, and how such signaling pathway is deregulated in pathological conditions. Integrating the use of biochemistry, molecular biology, mouse model and patient samples, we aim to define deregulation of signaling pathway that may lead to impairment of nutrient and energy homeostasis. This body of work will provide a physiological basis to identify molecular targets with great potential value in the development of therapeutic strategies to treat metabolic disorders. Sung Hee Um was awarded TJ Park Science Fellowship from POSCO TJ Park foundation, and a grant from Samsung science & technology Foundation.
[Selected Publications]
1. Kim HJ, Im DU, Chau GC, Mishra NK, Kim IS, Um SH*. Novel anti-adipogenic effect of CF3-allylated indole in 3T3-L1 cells. Chem Biol Interact. 2022 Jan 25352:109782.
2. Im DU, Kim SC, Chau GC, Um SH*. Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-Catenin Expression. Cells, 2019, 8(11), 1460-1474
3. Son SW, Chau GC, Kim ST, Um SH*. Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling. Cells. 2019, 8(10): 1137-1152
4. Seo DS, Chau GC, Baek KH, Um SH*. A single extra copy of Down syndrome critical region 1-4 results in impaired hepatic glucose homeostasis.&160Mol Metab.,&1602019, 21:&16082-89&160&160&160
5. Chau GC,1 Im DU,1 Kang TM, Bae JM, Won Kim, Pyo SN, Moon EY, and Um SH* (1equally contribution), mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J. Cell Biol.,&1602017, 216(7):2091-2105
6. Song M, Lee H, Jin B, Um SH* Kim DH*. Depot-specific differences in angiogenic capacity of adipose tissue in differential susceptibility to diet-induced obesity. Mol Metab, 2016, 5(11), 1113&82111120
7. Um SH*, Sticker JM, Chau GC, Vintersten K, Mueller M, Gangliff YG, Adams RH, Spetz JF, Elghazi L, Tsch&246p MH, Thomas G and Kozma SC*. S6K1-mediated pancreatic b-cell size is independent of intrauterine growth restriction. J Clin Invest. 2015, 125(7):2736-47
8. Kim KJ, Pyo S, Um SH*, S6K2 deficiency enhances ketone body production and increases PPARα activity in the liver. Hepatology 2012, 55(6):1727-37
* corresponding author
1. Kim HJ, Im DU, Chau GC, Mishra NK, Kim IS, Um SH*. Novel anti-adipogenic effect of CF3-allylated indole in 3T3-L1 cells. Chem Biol Interact. 2022 Jan 25352:109782.
2. Im DU, Kim SC, Chau GC, Um SH*. Carbamazepine Enhances Adipogenesis by Inhibiting Wnt/β-Catenin Expression. Cells, 2019, 8(11), 1460-1474
3. Son SW, Chau GC, Kim ST, Um SH*. Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling. Cells. 2019, 8(10): 1137-1152
4. Seo DS, Chau GC, Baek KH, Um SH*. A single extra copy of Down syndrome critical region 1-4 results in impaired hepatic glucose homeostasis.&160Mol Metab.,&1602019, 21:&16082-89&160&160&160
5. Chau GC,1 Im DU,1 Kang TM, Bae JM, Won Kim, Pyo SN, Moon EY, and Um SH* (1equally contribution), mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress. J. Cell Biol.,&1602017, 216(7):2091-2105
6. Song M, Lee H, Jin B, Um SH* Kim DH*. Depot-specific differences in angiogenic capacity of adipose tissue in differential susceptibility to diet-induced obesity. Mol Metab, 2016, 5(11), 1113&82111120
7. Um SH*, Sticker JM, Chau GC, Vintersten K, Mueller M, Gangliff YG, Adams RH, Spetz JF, Elghazi L, Tsch&246p MH, Thomas G and Kozma SC*. S6K1-mediated pancreatic b-cell size is independent of intrauterine growth restriction. J Clin Invest. 2015, 125(7):2736-47
8. Kim KJ, Pyo S, Um SH*, S6K2 deficiency enhances ketone body production and increases PPARα activity in the liver. Hepatology 2012, 55(6):1727-37
* corresponding author
(Tel) +82-31-299-6123,
(Email) shum@skku.edu