Genome Editing Laboratory(유전자교정 연구실)

Daesik Kim

CRISPR-based genome editing
유전자교정 연구실
We are working to develop and improve CRISPR-based genome editing technologies.
Our current research focuses on profiling and improving the genome-wide specificity of CRISPR systems such as programmable nucleases, Base editors, and Prime editors.

Major Areas of Research
1. Evaluating and enhancing target specificity of CRISPR systems
2. Genome editing for disease modeling and gene therapy
3. CRISPR screens for the identification of therapeutic targets
4. Development of a new CRISPR genome editing system
1. D. Kim et al., Unbiased investigation of specificities of prime editing systems in human cells NAR (2020) IF: 11.5
2. D. Kim et al., Genome-wide specificity of dCpf1 cytidine base editors. Nature communications (2020) IF: 12.1
3. D. Kim et al., Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases. Annual Review of Biochemistry (2019) IF: 30.3
4. D. Kim et al., Genome-wide target specificity of CRISPR RNA-guided adenine base editors. Nature Biotechnology (2019) IF: 31.9
5. D. Kim et al., Genome-wide target specificities of CRISPR RNA-guided programmable deaminases. Nature Biotechnology 35, 475-480 (2017) IF: 31.9
6. D. Kim et al., Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells. Nature Biotechnology 34, 863-868 (2016) IF: 31.9
7. D. Kim et al., Digenome-seq: Genome-wide Profiling of CRISPR-Cas9 Off-target Effects in Human Cells. Nature Methods 12, 237-243 (2015) IF: 28.5
(Tel) +82-31-299-6127,  (Email)