Laboratory of Drug Delivery and Cell Therapy(약물전달 및 세포치료 실험실)

Jee-Heon Jeong

Cell Therapy, Drug Delivery, 3D Culture System Laboratory
약물전달 및 세포치료 실험실
Our research interest consists of using drug delivery technology to improve the therapeutic effect of cytomedicine following transplantation.
Our research topics can be summarized as follow:
Research on improving the therapeutic effect of cytomedicine using 3D cell culture system and drug delivery system
Research on developing cell surface engineering technology to improve the therapeutic effect of cytomedicine
Selected Publications (2019-2022)

1. Shobha Regmi*, Pawan Kumar Raut*, Shiva Pathak, Prakash Shrestha, Pil-Hoon Park**, Jee-Heon Jeong**, “Enhanced viability and function of mesenchymal stromal cell spheroids is mediated via autophagy induction”, Autophagy (IF=16.02),17(10), Oct 2021, 2991-3010

2. Tiep Tien Nguyen, Cao Dai Phung, Jong Oh Kim, Chul Soon Yong, Jae-Ryong Kim, Simmyung Yook**, Jee-Heon Jeong**, “The impact of locally-delivered tacrolimus-releasing microspheres and polyethylene glycol-based islet surface modification on xenogeneic islet survival”, Journal of Controlled Release (IF=9.776), 336, Aug 2021, 274-284

3. Shobha Regmi*, Yoogin Seo*, Ji-Su Ahn*, Shiva Pathak, Suman Acharya, Tiep Tien Nguyen, Simmyung Yook, Jong-Hyuk Sung, Jun-Beom Park, Jong Oh Kim, Chul Soon Young, Hyung-Sik Kim**, and Jee-Heon Jeong**, “Heterospheroid formation improves therapeutic efficacy of mesenchymal stem cells in murine colitis through immunomodulation and epithelial regeneration, Biomaterials (IF=12.479), 271, Apr 2021, 120752

4. Tung Thanh Pham, Phuong Le Tran, Cao Dai Phung, Hanh Thuy Nguyen, Canh Hung Nguyen, Chul Soon Yong, Jong Oh Kim, Simmyung Yook**, Jee-Heon Jeong**, “Surface triggered in situ gelation for tunable conformal hydrogel coating of therapeutic cells and biomedical devices”, Advanced Functional Materials (IF=18.808), 31, May 2021, 2010169 (Back cover)

5. Shiva Pathak*, Suman Acharya*, Shobha Regmi, Prakash Shrestha, Zhiwei You, Young Kyung Bae, Min Hui Park, Simmyung Yook, Jae-Ryong Kim, So Young Park, Daewon Jeong, Chul Soon Yong, Jong Oh Kim, Jae Hoon Chang**, Jee-Heon Jeong**, “Particulate-Based Single-Dose Local Immunosuppressive Regimen for Inducing Tolerogenic Dendritic Cells in Xenogeneic Islet Transplantation”, Advanced Healthcare Materials (IF=9.933), 10(2), Jan 2021, 2001157

6. Tiep Tien Nguyen, Fakhrossadat Emami, Simmyung Yook**, Hanh Thuy Nguyen, Tung Thanh Pham, Shiva Pathak, Shobha Regmi, Jong Oh. Kim, Chul Soon Yong, Jae-Ryong Kim, Jee-Heon Jeong** “Local release of NECA (5’-(N-ehylcarboxamido)adenosine) from implantable polymeric sheets for enhanced islet revascularization in extrahepatic transplantation site”, Journal of Controlled Release (IF=9.776), 312, May 2020, 509-518

7. Shobha Regmi, Shiva Pathak, Mahesh Raj Nepal, Prakash Shrestha, Junhyeung Pakr, Jong Oh Kim, Chul Soon Yong, Dong-Young Choi, Jae-Hoon Chang, Tae Cheon Jeong, Gorka Orive, Simmyung Yook**, Jee-Heon Jeong** “Inflammation-triggered local drug release ameliorates colitis by inhibiting dendritic cell migration and Th1/Th17 differentiation”, Journal of Controlled Release (IF=9.776), 316 Dec 2019, 138-149

8. Tiep Tien Nguyen*, Tung Thanh Pham*, Hanh Thuy Nguyen, Mahesh Raj Nepal, Cao Dai Phung, Zhiwei You, Nikita Katila, Nirmala Tilija Pun, Dong-Young Choi, Pil-Hoon Park, Chul Soon Yong, Jong Oh Kim, Simmyung Yook**, Jee-Heon Jeong**, “Engineering cell-pharicle hybrids” of pancreatic islets and bioadhesive FK506-loaded polymeric microspheres for local immunomodulation in xenogeneic islet transplantation”, Biomaterials (IF=12.479), 221, Nov 2019, 119415

9. Shiva Pathak*, Tung Thanh Pham*, Jee-Heon Jeong**, Youngro Byun**, “Immunoisolation of pancreatic islets via thin-layer surface modification”, Journal of Controlled Release (IF=9.776), 305(10), July 2019, 176-193

10. Shiva Pathak, Shobha Regmi, Prakash Shrestha, Inho Choi, Kyoung-Oh Doh, Jee-Heon Jeong, “Mesenchymal stem cell capping on ECM-anchored caspase inhibitor-loaded PLGA microspheres for intraperitoneal injection in DSS-induced murine colitis”, Small (IF=13.281), 15(23), June 2019, 1901269 (Cover Story)

*These authors equally contributed as first author
**These authors equally contributed as corresponding author
(Tel) +82-31-299-6165,  (Email)