The Laboratory of Healthy Aging and Epigenetics is extensively conducting research, in collaboration with various domestic and international institutions, on accelerated aging, cardiovascular diseases, cancer, aging-related diseases, and the clinical epidemiological risk factors affecting them, as well as epigenomic biomarkers including DNA methylation aging indicators.
1) Research on Social Environmental and Clinical Epidemiological Risk Factors and Accelerated Aging/Aging-Related Diseases
- The impact of social, cultural, and environmental factors and clinical epidemiological factors on accelerated aging from a life-course perspective
- Studies on the association between accelerated aging and aging-related diseases such as cardiovascular/metabolic diseases, cancer, cognitive decline, and dementia
2) Research on Health Effects of Epigenomic Aging Indicators and Biomarkers
- Discovery of biomarkers including DNA methylation-based epigenomic aging indicators (epigenetic clocks)
- Research on risk factors and related diseases associated with variations in epigenetic biomarkers
[Selected Publications]
1. Associations of Urban Blue and Green Spaces with Coronary Artery Calcification in Black Individuals and Disadvantaged Neighborhoods (2024), Circulation, DOI: 10.1161/CIRCULATIONAHA.123.067992
2. Inequalities in Urban Greenness and Epigenetic Aging: Different Associations by Race and Neighborhood Socioeconomic Status (2023), Science Advances, 9 (26) eadf 8140
3. Associations of Adverse Childhood Experiences with Accelerated Epigenetic Aging in Midlife (2023), JAMA Network Open 6 (6) e2317987
4. Genome-Wide DNA Methylation Association Study of Recent and Cumulative Marijuana Use in Middle Aged Adults (2023), Molecular Psychiatry 1-11
5. Relative Contributions of Six Lifestyle- and Health-related Exposures to Epigenetic Aging: The Coronary Artery Risk Development in Young Adults (CARDIA) Study (2022), Clinical Epigenetics 14 (1) 1-12
6. Associations of Exposure to Metal and Metal Mixtur4es with Thyroid Hormones: Results from the NHANES 2007-2012 (2022), Environmental Research e113413
7. Accelerated Epigenetic Age among Women with Invasive Cervical Cancer and HIV-Infection in Nigeria (2022), Frontiers in Public Health 1193
8. DNA Methylation GrimAge and Incident Diabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study (2021), Diabetes 70 (6) 1404-1413
9. Pre-Diagnostic Carbohydrate Intake and Treatment Failure after Radical Prostatectomy for Early-Stage Prostate Cancer (2019), Cancer Causes & Control 30 (3) 271-279
10. Association between CASR Polymorphisms, Calcium Intake, and Colorectal Cancer Risk (2018), Genes, Chromosomes and Cancer, c22674
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(Email) kyeezu.kim@skku.edu