SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
Integrative Bio-manufacturing Lab (IBM)(조직공학연구실)
Geun Hyung Kim
Personalized healthcare/Intelligent medical robotics/Fabrication of artificial organs/Organ-on-a-chip/Regenerative medicine Laboratory
1. Research objective 1: Employment of various biomaterials and biofabrication systems for regenerative medicine purposes.
We aim to fabricate functional hydrogel-based biomimetic tissue substitutes for tissue regenerative applications via the investigation of various biomaterials and biofabrication systems to provide favorable cellular microenvironments for the host cells. Through in vivo assessment in an appropriate animal defect model, the regenerative efficacy of the fabricated tissue substitute will be evaluated.
2. Research objective 2: Development and design of integrative biomanufacturing system for recapitulating stem cell niche in terms of physical/chemical/biological aspects and disease microenvironments including degenerative diseases and muscular dystrophy & various cancers. We aim to design and fabricate novel hydrogel-based 3D tissue constructs with biomimetic and hierarchical architecture for stem cell fate determination, novel co-culture system, and tumor microenvironment (TME) via 3D bioprinting, cell-electrospinning, nano/microfabrication systems and develop functional in vitro disease model platforms as an organ-on-a-chip model and stem cell organoid engineering to modulate cell-cell and cell-matrix interactions for various cellular functions and their subsequent contribution to in vitro tissue model.
We aim to fabricate functional hydrogel-based biomimetic tissue substitutes for tissue regenerative applications via the investigation of various biomaterials and biofabrication systems to provide favorable cellular microenvironments for the host cells. Through in vivo assessment in an appropriate animal defect model, the regenerative efficacy of the fabricated tissue substitute will be evaluated.
2. Research objective 2: Development and design of integrative biomanufacturing system for recapitulating stem cell niche in terms of physical/chemical/biological aspects and disease microenvironments including degenerative diseases and muscular dystrophy & various cancers. We aim to design and fabricate novel hydrogel-based 3D tissue constructs with biomimetic and hierarchical architecture for stem cell fate determination, novel co-culture system, and tumor microenvironment (TME) via 3D bioprinting, cell-electrospinning, nano/microfabrication systems and develop functional in vitro disease model platforms as an organ-on-a-chip model and stem cell organoid engineering to modulate cell-cell and cell-matrix interactions for various cellular functions and their subsequent contribution to in vitro tissue model.
[Selected Publications]
1. 3D bioprinting using a new photo-crosslinking method for muscle tissue restoration, npj Regenerative Medicine, 2023. (IF: 14.4)
2. Photosynthetic Cyanobacteria can Clearly Induce Efficient Muscle Tissue Regeneration of Bioprinted Cell-Constructs, Adv. Funct. Mater., 2209157, 2022. (IF: 19.924)
3. Collagen-based shape-memory biocomposites, Appl. Phys. Rev., 9, 021415, 2022. (IF: 19.527).
4. A multicellular bioprinted cell construct for vascularized bone tissue regeneration, Chem. Eng. J., 431, 133882, 2022. (IF: 16.744).
5. A Microfluidic Device to Fabricate One-Step Cell Bead-Laden Hydrogel Struts for Tissue Engineering, Small, 18, 2106487, 2022. (IF: 15.153).
6. Bio-printing of aligned GelMa-based cellladen structure for muscle tissue regeneration, Bioact. Mater., 8, 57, 2022. (IF: 16.874).
7. A Bioprinting Process Supplemented with In Situ Electrical Stimulation Directly Induces Significant Myotube Formation and Myogenesis, Adv. Funct. Mater., 31, 2105170, 2021. (IF: 19.924).
8. Bone tissue engineering via application of a collagen/hydroxyapatite 4D-printed biomimetic scaffold for spinal fusion, Appl. Phys. Rev., 8, 021403, 2021. (IF: 19.527).
9. Self-aligned myofibers in 3D bioprinted extracellular matrix-based construct accelerate skeletal muscle function restoration, Appl. Phys. Rev., 8, 021405, 2021. (IF: 19.527).
10. Bioprinted hASC-laden structures with cell-differentiation niches for muscle regeneration, Chem. Eng. J., 419, 129570, 2021. (IF: 16.744).
1. 3D bioprinting using a new photo-crosslinking method for muscle tissue restoration, npj Regenerative Medicine, 2023. (IF: 14.4)
2. Photosynthetic Cyanobacteria can Clearly Induce Efficient Muscle Tissue Regeneration of Bioprinted Cell-Constructs, Adv. Funct. Mater., 2209157, 2022. (IF: 19.924)
3. Collagen-based shape-memory biocomposites, Appl. Phys. Rev., 9, 021415, 2022. (IF: 19.527).
4. A multicellular bioprinted cell construct for vascularized bone tissue regeneration, Chem. Eng. J., 431, 133882, 2022. (IF: 16.744).
5. A Microfluidic Device to Fabricate One-Step Cell Bead-Laden Hydrogel Struts for Tissue Engineering, Small, 18, 2106487, 2022. (IF: 15.153).
6. Bio-printing of aligned GelMa-based cellladen structure for muscle tissue regeneration, Bioact. Mater., 8, 57, 2022. (IF: 16.874).
7. A Bioprinting Process Supplemented with In Situ Electrical Stimulation Directly Induces Significant Myotube Formation and Myogenesis, Adv. Funct. Mater., 31, 2105170, 2021. (IF: 19.924).
8. Bone tissue engineering via application of a collagen/hydroxyapatite 4D-printed biomimetic scaffold for spinal fusion, Appl. Phys. Rev., 8, 021403, 2021. (IF: 19.527).
9. Self-aligned myofibers in 3D bioprinted extracellular matrix-based construct accelerate skeletal muscle function restoration, Appl. Phys. Rev., 8, 021405, 2021. (IF: 19.527).
10. Bioprinted hASC-laden structures with cell-differentiation niches for muscle regeneration, Chem. Eng. J., 419, 129570, 2021. (IF: 16.744).
(Tel) +82-31-290-7828,
(Email) gkimbme@skku.edu