SUNGKYUNKWAN UNIVERSITY SCHOOL OF MEDICINE
CLOSE HEADER
Laboratory
Our lab focuses on studying molecular mechanisms underlying survival of Salmonella, a Gram (-) pathogen, inside host cells.
1. Iron regulation of Salmonella virulence.
2. Identification of novel functions of Salmonella virulence proteins.
3. Molecular mechanisms of formation of Salmonella biofilm in response to metal signals.
1. Iron regulation of Salmonella virulence.
2. Identification of novel functions of Salmonella virulence proteins.
3. Molecular mechanisms of formation of Salmonella biofilm in response to metal signals.
[Selected Publications]
1. Park M, Kim H, Nam D, Kweon DH, Shin D. The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments. Front Microbiol. 2019 Dec 610:2831.
2. Park M, Nam D, Kweon DH, Shin D. ATP reduction by MgtC and Mg2+ homeostasis by MgtA and MgtB enables Salmonella to accumulate RpoS upon low cytoplasmic Mg2+ stress. Mol Microbiol. 2018 Oct110(2):283-295.
3. Kim H, Lee H, Shin D. Lon-mediated proteolysis of the FeoC protein prevents Salmonella enterica from accumulating the Fe(II) transporter FeoB under high-oxygen conditions. J Bacteriol. 2015 Jan 1197(1):92-8.
4. Choi E, Kim H, Lee H, Nam D, Choi J, Shin D. The iron-sensing Fur regulator controls expression timing and levels of Salmonella pathogenicity island 2 genes in the course of environmental acidification. Infect Immun. 2014 Jun82(6):2203-10.
5. Kim H, Lee H, Shin D. The FeoC protein leads to high cellular levels of the Fe(II) transporter FeoB by preventing FtsH protease regulation of FeoB in Salmonella enterica. J Bacteriol. 2013 Aug195(15):3364-70.
6. Shin D, Lee EJ, Huang H, Groisman EA. A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit. Science. 2006 Dec 8314(5805):1607-9.
1. Park M, Kim H, Nam D, Kweon DH, Shin D. The mgtCBR mRNA Leader Secures Growth of Salmonella in Both Host and Non-host Environments. Front Microbiol. 2019 Dec 610:2831.
2. Park M, Nam D, Kweon DH, Shin D. ATP reduction by MgtC and Mg2+ homeostasis by MgtA and MgtB enables Salmonella to accumulate RpoS upon low cytoplasmic Mg2+ stress. Mol Microbiol. 2018 Oct110(2):283-295.
3. Kim H, Lee H, Shin D. Lon-mediated proteolysis of the FeoC protein prevents Salmonella enterica from accumulating the Fe(II) transporter FeoB under high-oxygen conditions. J Bacteriol. 2015 Jan 1197(1):92-8.
4. Choi E, Kim H, Lee H, Nam D, Choi J, Shin D. The iron-sensing Fur regulator controls expression timing and levels of Salmonella pathogenicity island 2 genes in the course of environmental acidification. Infect Immun. 2014 Jun82(6):2203-10.
5. Kim H, Lee H, Shin D. The FeoC protein leads to high cellular levels of the Fe(II) transporter FeoB by preventing FtsH protease regulation of FeoB in Salmonella enterica. J Bacteriol. 2013 Aug195(15):3364-70.
6. Shin D, Lee EJ, Huang H, Groisman EA. A positive feedback loop promotes transcription surge that jump-starts Salmonella virulence circuit. Science. 2006 Dec 8314(5805):1607-9.
(Tel) +82-31-299-6224,
(Email) shind@skku.edu